Compounds > thiocoraline

Page last updated: 2024-11-13

thiocoraline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

thiocoraline: a depsipeptide from marine actinomycete, Micromonospora; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	70698112
CHEBI ID	69052
MeSH ID	M0283010

Synonyms (4)

Synonym
173046-02-1
thiocoraline
CHEBI:69052
Q27137393

Research Excerpts

Overview

Thiocoraline is a potent Notch pathway activator and an inhibitor of MTC-TT cell proliferation at low nanomolar concentrations. It belongs to the family of bisintercalator natural products that bind duplex DNA.

Excerpt	Reference	Relevance
"Thiocoraline is a potent Notch pathway activator and an inhibitor of MTC-TT cell proliferation at low nanomolar concentrations."	( Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line. Bugni, TS; Chen, H; Dammalapati, A; Eide, J; Jaskula-Sztul, R; Korlesky, C; Tesfazghi, S; Wyche, TP, 2013)	2.55
"Thiocoraline is a thiodepsipeptide with potent antitumor activity. "	( A new scaffold of an old protein fold ensures binding to the bisintercalator thiocoraline. Biswas, T; de la Calle, F; Garneau-Tsodikova, S; Lombó, F; Salas, JA; Tsodikov, OV; Zolova, OE, 2010)	2.03
"Thiocoraline is a potent new marine anti-cancer drug in vitro, which will be tested in phase I clinical studies shortly. "	( In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug. Beijnen, JH; Brandon, EF; Manzanares, I; Meijerman, I; Schellens, JH; Sparidans, RW, 2004)	2.01
"Thiocoraline is a thiodepsipeptide antitumor compound produced by two actinomycetes Micromonospora sp. "	( Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species. Braña, AF; Castro, A; de la Calle, F; Lombó, F; Méndez, C; Salas, JA; Sánchez-Puelles, JM; Velasco, A, 2006)	2.02
"Thiocoraline is a thiodepsipeptide antitumor agent that belongs to the family of bisintercalator natural products that bind duplex DNA through their two planar intercalating moieties. "	( Characterization of TioF, a tryptophan 2,3-dioxygenase involved in 3-hydroxyquinaldic acid formation during thiocoraline biosynthesis. Garneau-Tsodikova, S; King, A; Pero, JM; Sheoran, A; Velasco, A, 2008)	2
"Thiocoraline (1) is a new antitumor antibiotic isolated from the mycelium of Micromonospora sp. "	( Thiocoraline, a novel depsipeptide with antitumor activity produced by a marine Micromonospora. II. Physico-chemical properties and structure determination. Cañedo, LM; Fernández Puentes, JL; Perez Baz, J; Silva Elipe, MV, 1997)	3.18

Actions

Excerpt	Reference	Relevance
"Thiocoraline does not inhibit DNA-topoisomerase II enzymes in vitro, nor does it induce DNA breakage in cells exposed to effective drug concentrations."	( Mode of action of thiocoraline, a natural marine compound with anti-tumour activity. Bergamaschi, D; Bonfanti, M; Catapano, CV; D'Incalci, M; Erba, E; Faircloth, G; Faretta, M; Jimeno, J; Ronzoni, S; Taverna, S, 1999)	1.36

Treatment

Excerpt	Reference	Relevance
"Thiocoraline treatment decreased cell proliferation in a dose- and time-dependent manner."	( Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line. Bugni, TS; Chen, H; Dammalapati, A; Eide, J; Jaskula-Sztul, R; Korlesky, C; Tesfazghi, S; Wyche, TP, 2013)	2.55

Dosage Studied

Excerpt	Relevance	Reference
" Pharmacokinetic analysis showed that thiocoraline has distinct pharmacokinetic profiling when dosed in different formulation solutions."	( Validation of a sensitive assay for thiocoraline in mouse plasma using liquid chromatography-tandem mass spectrometry. Aviles, P; Calvo, P; Faircloth, G; Guillen, MJ; Lee, W; Ly, C; Manzanares, I; Yin, J, 2003)	0.86

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
peptide	Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

Pathway	Proteins	Compounds
thiocoraline biosynthesis	4	15

Research

Studies (30)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (16.67)	18.2507
2000's	10 (33.33)	29.6817
2010's	14 (46.67)	24.3611
2020's	1 (3.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.88 (24.57)
Research Supply Index	3.43 (2.92)
Research Growth Index	4.73 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.88)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (96.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
kynurenic acid Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.. kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.	2.04	1	monohydroxyquinoline; quinolinemonocarboxylic acid	G-protein-coupled receptor agonist; human metabolite; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist; Saccharomyces cerevisiae metabolite
bromodeoxyuridine Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.	2	1	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent
adenosine monophosphate Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.	2.25	1	adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
quinoxalines quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.	3.56	2	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene
quinaldic acid [no description available]	2.03	1	quinolinemonocarboxylic acid	human metabolite; Saccharomyces cerevisiae metabolite
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.46	2	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
coenzyme a [no description available]	2.06	1	adenosine 3',5'-bisphosphate	coenzyme; Escherichia coli metabolite; mouse metabolite
triostin a triostin A: RN given refers to triostin A; see also record for triostin C	3.13	1
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	7.1	1	cysteinium	fundamental metabolite
dermorphin dermorphin: opiate-like peptide present in amphibian skin	2.02	1	oligopeptide
bbm-928 a BBM-928 A: see also BBM-928	3.13	1
echinomycin Echinomycin: A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.	4.05	4	cyclodepsipeptide
sandramycin sandramycin: depsipeptide, structure given in first source; isolated from Nocardioides sp. ATCC 39419	3.13	1
triostin c triostin C: antibiotic product from a Streptomyces S-2-210 resembling Staphylococcus aureus; RN given refers to triostin C; see also record for triostin A; structure	2.08	1

Condition	Relationship Strength	Studies
Cancer of the Thyroid [description not available]	2.08	1
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	2.08	1
Carcinoma, Neuroendocrine A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round blue cells, granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small (oat) cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)	2.08	1
Disease Exacerbation [description not available]	2.1	1
Argentaffinoma [description not available]	2.1	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1
Carcinoid Tumor A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)	2.1	1
Breast Cancer [description not available]	2.05	1
Carcinoma, Non-Small Cell Lung [description not available]	2.05	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.05	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.05	1
Cancer of Lung [description not available]	2.05	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.05	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.41	2
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.99	1
Cancer of Colon [description not available]	1.99	1
Colonic Neoplasms Tumors or cancer of the COLON.	1.99	1

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