thiocoraline and Leukemia-P388

thiocoraline has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for thiocoraline and Leukemia-P388

Article	Year
Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities. The Journal of antibiotics, 1997, Volume: 50, Issue:9 A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis. Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Depsipeptides; Fermentation; Leukemia P388; Microbial Sensitivity Tests; Micromonospora; Peptides; Tumor Cells, Cultured	1997

Article

Year

Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities.

The Journal of antibiotics, 1997, Volume: 50, Issue:9

A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Depsipeptides; Fermentation; Leukemia P388; Microbial Sensitivity Tests; Micromonospora; Peptides; Tumor Cells, Cultured

1997