Compounds > resorantel
Page last updated: 2024-11-06

resorantel

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Resorantel is an anthelmintic drug used primarily in veterinary medicine to treat parasitic infections in animals, particularly tapeworms in ruminants. It has a broad spectrum of activity against various cestode species. The mechanism of action of resorantel involves disrupting the parasite's energy metabolism by inhibiting the enzyme succinate dehydrogenase. This enzyme plays a crucial role in the electron transport chain, which is essential for ATP production in the parasite. By inhibiting this enzyme, resorantel disrupts the parasite's energy supply, leading to its death. Resorantel is typically administered orally to animals, and it is well-absorbed from the gastrointestinal tract. It is then distributed throughout the body, reaching high concentrations in the tissues where parasites reside. Resorantel is commonly used in livestock, such as cattle, sheep, and goats, to treat tapeworm infections, which can cause significant weight loss and reduced productivity in these animals. Research on resorantel focuses on understanding its efficacy against different parasite species, optimizing its administration, and exploring potential adverse effects. It is also being investigated for its potential to treat parasitic infections in humans, though it is currently not approved for human use.'

resorantel: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65696
CHEMBL ID2105347
SCHEMBL ID1027956
MeSH IDM0041000

Synonyms (36)

Synonym
resorantel
n-(4-bromophenyl)-2,6-dihydroxybenzamide
FT-0655787
resorantelum [inn-latin]
unii-2i8v5q9a78
4'-bromo-gamma-resorcylanilide
4'-brom-2,6-dihydroxybenzanilid
resorantel [inn]
resorantelum
einecs 244-040-9
hoe 296 v
2i8v5q9a78 ,
benzamide, n-(4-bromophenyl)-2,6-dihydroxy-
20788-07-2
A814899
hoe-296-v
hoe-296 v
CHEMBL2105347
AKOS015896441
SCHEMBL1027956
resorantel [mi]
DTXSID80174879
sr-01000945074
SR-01000945074-1
AS-65720
E75929
sodiumbisulfide
CCG-267556
Q27254786
resorantel 100 microg/ml in acetonitrile
S4882
HY-121477
CS-0082168
Z1574812100
SY113738
mfcd00864511

Research Excerpts

Treatment

ExcerptReferenceRelevance
"Treatment with resorantel at 65 mg/kg or niclosamide at 50 mg/kg however, caused expulsion of the strobilae within 16--24 hours after treatment and at autopsy, lambs were free of scoleces of T."( The efficacy of anthelmintics against Thysaniezia giardi in South Africa.
Davies, PV; Geyser, TL; Récio, M; Van Schalkwyk, PC, 1981)		0.6

Dosage Studied

ExcerptRelevanceReference
" was tested in sheep at a dosage rate of 65 mg kg-1 live mass."( The anthelmintic efficacy of resorantel against cestodes in sheep.
Ashburner, AJ; du Plessis, CA; Gruss, B; Malan, FS; Roper, NA, 1988)		0.57
"Resorantel at a dosage rate of 130 mg kg-1 live body mass was found to be highly effective against Houttuynia struthionis in ostriches when dosed alone or in combination with fenbendazole or levamisole."( The anthelmintic efficacy of resorantel against Houttuynia struthionis in ostriches.
Ashburner, AJ; du Plessis, C; Gruss, B; Malan, FS; Roper, NA, 1988)		2.01
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (83.33)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.52 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
albendazole
[no description available]		1.9610aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator
fenbendazole
Fenbendazole: Antinematodal benzimidazole used in veterinary medicine.. fenbendazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted at positons 2 and 5 by (methoxycarbonyl)amino and phenylsulfanediyl groups, respectively. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.		1.9710aryl sulfide;
benzimidazoles;
carbamate ester		antinematodal drug
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		2.0110catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
mebendazole
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.. mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.		1.9610aromatic ketone;
benzimidazoles;
carbamate ester		antinematodal drug;
microtubule-destabilising agent;
tubulin modulator
niclosamide
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.		1.9610benzamides;
C-nitro compound;
monochlorobenzenes;
salicylanilides;
secondary carboxamide		anthelminthic drug;
anticoronaviral agent;
antiparasitic agent;
apoptosis inducer;
molluscicide;
piscicide;
STAT3 inhibitor
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.		1.9410adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		1.9410adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
levamisole
Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.		1.97106-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazoleantinematodal drug;
antirheumatic drug;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
immunological adjuvant;
immunomodulator
cambendazole
Cambendazole: A nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.		1.9610
293b cpd
6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane: RN given for (trans-(+-))-isomer		2.01101-benzopyran
glycogen
glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.		1.9410
almokalant
almokalant: structure given in first source		2.0110
fumarates
Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)		1.9410butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
hmr 1556
HMR 1556: an I(Ks) channel blocker; structure in first source		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Ovine Diseases
[description not available]		02.6530
Fasciolopsiasis
[description not available]		01.9610
Infections, Nematode
[description not available]		01.9610
Bertielliasis
[description not available]		02.3720
Avian Diseases
[description not available]		01.9710