Page last updated: 2024-11-12

neopeltolide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

neopeltolide: a macrolide from a lithistid sponge of the family Neopeltidae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16115403
CHEMBL ID223238
MeSH IDM0509142

Synonyms (4)

Synonym
neopeltolide
CHEMBL223238
YRSJLYCTJWNTMF-NRBUTUAXSA-N
[(1r,5r,7r,9s,11r,13r)-7-methoxy-9-methyl-3-oxo-5-propyl-4,15-dioxabicyclo[9.3.1]pentadecan-13-yl] (z)-5-[2-[(z)-3-(methoxycarbonylamino)prop-1-enyl]-1,3-oxazol-4-yl]pent-2-enoate

Research Excerpts

Overview

Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines.

ExcerptReferenceRelevance
"Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively."( Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
Botelho, JC; Guzmán, E; Harmody, D; Linley, P; McCarthy, PJ; Pitts, TP; Pomponi, SA; Reed, JK; Wright, AE, 2007
)
2.5

Effects

ExcerptReferenceRelevance
"Neopeltolide has been proven to be a new type of inhibitor of the cytochrome bc"( Natural Product Neopeltolide as a Cytochrome bc
Song, YJ; Wang, YX; Wu, QY; Yang, GF; Yang, JF; Zhang, R; Zhu, XL, 2019
)
1.58
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (31)

Assay IDTitleYearJournalArticle
AID280375Cell cycle arrest in A549 cells by accumulation at G2/M phase at 100 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500483Antifungal activity against Saccharomyces cerevisiae W303-1A in glycerol agar media at 1 ug after 24 hrs by disk diffusion method2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280370Cytotoxicity against mouse NCI-P388 cells by MTT assay2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500487Inhibition of bc1 complex in human A549 cells assessed as reduction in ATP production in presence of 10 mM of 2-DG2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280378Cell cycle arrest in A549 cells by accumulation at G2/M phase at 10 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280369Cytotoxicity against human NCI-ADR-RES cells by MTT assay2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500493Inhibition of Saccharomyces cerevisiae Cytochrome b-c1 complex2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280367Antifungal activity against Candida albicans ATCC 44506 by broth dilution assay2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280373Cell cycle arrest in A549 cells by accumulation at G1 phase at 100 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280377Cell cycle arrest in A549 cells by accumulation at S phase at 10 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500495Inhibition of bovine Cytochrome b-c1 complex2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280371Cytotoxicity against p53 mutated PANC1 cells ATCC CRL1469 by MTT assay2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280384Cell cycle arrest in A549 cells by accumulation at G2/M phase at 0.1 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280368Cytotoxicity against human A549 cells ATCC CCL-185 by MTT assay2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280381Cell cycle arrest in A549 cells by accumulation at G2/M phase at 1 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500498Effect on cytochrome c oxidase activity of respiratory chain in Saccharomyces cerevisiae W303-1A mitochondria at 100 mM2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID500484Antifungal activity against Saccharomyces cerevisiae W303-1A in glucose agar media at 1 ug after 24 hrs by disk diffusion method2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID500470Inhibition of cell proliferation in human HCT116 cells in after 48 hrs2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280366Antifungal activity against Candida albicans ATCC 44506 at 25 ug/disk by agar diffusion assay2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500496Effect on NADH dehydrogenase in respiratory chain of Saccharomyces cerevisiae W303-1A mitochondria at 100 mM2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280374Cell cycle arrest in A549 cells by accumulation at S phase at 100 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500468Inhibition of cell proliferation in human A549 cells in after 48 hrs2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280380Cell cycle arrest in A549 cells by accumulation at S phase at 1 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280383Cell cycle arrest in A549 cells by accumulation at S phase at 0.1 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280382Cell cycle arrest in A549 cells by accumulation at G1 phase at 0.1 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500715Effect on succinate:ubiquinone oxidoreductase activity of respiratory chain in Saccharomyces cerevisiae W303-1A mitochondria at 100 mM2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID500488Inhibition of bc1 complex in human A549 cells assessed as reduction in ATP production2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280379Cell cycle arrest in A549 cells by accumulation at G1 phase at 1 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID500469Inhibition of cell proliferation in human PC3 cells in after 48 hrs2008Nature chemical biology, Jul, Volume: 4, Issue:7
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
AID280376Cell cycle arrest in A549 cells by accumulation at G1 phase at 10 nM2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
AID280372Cytotoxicity against p53 mutated NCI-DLD1 cells by MTT assay2007Journal of natural products, Mar, Volume: 70, Issue:3
Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (42.86)29.6817
2010's18 (51.43)24.3611
2020's2 (5.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.22 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index4.50 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (8.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (91.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]