Page last updated: 2024-11-12
madangamine a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
madangamine A: from sponge Xestospongia ingens; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 9980274 |
| CHEMBL ID | 4786764 |
| MeSH ID | M0495635 |
Synonyms (4)
| Synonym |
|---|
| madangamine a |
| 155944-26-6 |
| DTXSID701015847 |
| CHEMBL4786764 |
Research Excerpts
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "Treatment with madangamine A increased the levels of LC3-II and p62, autophagy-related proteins, concomitant with growth inhibition." | ( Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. Chida, N; Kawano, S; Miura, K; Sato, T; Simizu, S; Suto, T, 2021) | 1.29 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (16)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1719514 | Induction of autophagosome formation in human HeLa cells assessed as increase in LC3 puncta at 10 uM after 24 hrs in presence of Baf A1 by Alexa Fluor 488 staining based fluorescence microscopic analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719519 | Modulation of autophagy in human HeLa cells assessed as increase in LC3-2 protein level at 10 uM after 24 hrs in presence of chloroquine by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719524 | Inhibition of autophagy in human HeLa cells assessed as decrease in cathepsin B at 10 nM after 24 hrs by immunoblot analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719516 | Induction of autophagosome formation in HT-1080 cells assessed as increase in LC3 puncta at 10 uM after 24 hrs by Alexa Fluor 488 staining based fluorescence microscopic analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719515 | Induction of autophagosome formation in human HeLa cells assessed as increase in LC3 puncta at 10 uM after 6 hrs in presence of rapamycin by Alexa Fluor 488 staining based fluorescence microscopic analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719512 | Induction of autophagosome formation in human HeLa cells assessed as increase in LC3 puncta at 10 uM after 24 hrs by Alexa Fluor 488 staining based fluorescence microscopic analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719522 | Inhibition of autophagy in human HeLa cells assessed as increase in lysosomal pH at 10 uM after 24 hrs by LysoTracker Red DND-99 staining based fluorescence microscopic method | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719517 | Induction of autophagosome formation in SK-MEL-28 cells assessed as increase in LC3 puncta at 10 uM after 24 hrs by Alexa Fluor 488 staining based fluorescence microscopic analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719507 | Antiproliferative activity against human HeLa cells assessed as cell viability at 1 uM after 24 hrs by MTT assay relative to control | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719508 | Modulation of autophagy in human HeLa cells assessed as increase in LC3-2 protein level at 1 to 20 uM after 24 hrs by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719509 | Inhibition of autophagy in human HeLa cells assessed as increase in P62 protein level at 1 to 20 uM after 24 hrs by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719510 | Antiproliferative activity against human HeLa cells assessed as cell viability at 20 uM after 24 hrs by MTT assay relative to control | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719520 | Inhibition of autophagy in human HeLa cells assessed as increase in P62 protein level at 10 uM after 24 hrs in presence of Baf A1 by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719518 | Modulation of autophagy in human HeLa cells assessed as increase in LC3-2 protein level at 10 uM after 24 hrs in presence of Baf A1 by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719511 | Antiproliferative activity against human HeLa cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| AID1719521 | Inhibition of autophagy in human HeLa cells assessed as increase in P62 protein level at 10 uM after 24 hrs in presence of chloroquine by Western blot analysis | 2021 | Bioorganic & medicinal chemistry, 03-15, Volume: 34 | Identification of madangamine A as a novel lysosomotropic agent to inhibit autophagy. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.78
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.78) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||