Compounds > macranthoidin b
Page last updated: 2024-11-13

macranthoidin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators
FloraRankFlora DefinitionFamilyFamily Definition
LoniceragenusA plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.[MeSH]CaprifoliaceaeA plant family of the order Dipsacales, subclass Asteridae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID71307567
MeSH IDM0222077

Synonyms (20)

Synonym
macranthoidin b ,
unii-9s74s1aghc
3-o-beta-d-glucopyranosyl-(1-4)-beta-d-glucopyranosyl-(1-3)-alpha-l-rhamnopyranosyl-(1-2)-alpha-l-arabinopyranosyl-3,23-dihydroxyolean-12-en-28-o-d-glucopyranosyl-(1-6)glucopyranoside
136849-88-2
olean-12-en-28-oic acid, 3-((o-beta-d-glucopyranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-3)-o-6-deoxy-alpha-l-mannopyranosyl-(1-2)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy, 6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl ester, (3beta,4alpha)-
9s74s1aghc ,
olean-12-en-28-oic acid, 3-((o-beta-d-glucopyranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-3)-o-6-deoxy-alpha-l-mannopyranosyl-(1-2)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy-, 6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl est
S3916
CS-3911
AC-33964
HY-N0864
3-((o-.beta.-d-glucopyranosyl-(1->4)-o-.beta.-d-glucopyranosyl-(1->3)-o-6-deoxy-.alpha.-l-mannopyranosyl-(1->2)-.alpha.-l-arabinopyranosyl)oxy)-23-hydroxy-olean-12-en-28-oic acid 6-o-.beta.-d-glucopyranosyl-.beta.-d-glucopyranosyl ester, (3.beta.,4.alpha.
macranthoidinb
mfcd20487834
AKOS037514731
AS-75343
macranthoiside i
olean-12-en-28-oic acid, 3-[(o-beta-d-glucopyranosyl-(1-->4)-o-beta-d-glucopyranosyl-(1-->3)-o-6-deoxy-alpha-l-mannopyranosyl-(1-->2)-alpha-l-arabinopyranosyl)oxy]-23-hydroxy-, 6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl ester, (3beta,4alpha)-
CCG-270678
Q27273041

Research Excerpts

Overview

Macranthoidin B (MB) is a potent inducer of ROS-mediated apoptosis in cancer. Its mechanism of action is poorly understood.

ExcerptReferenceRelevance
"Macranthoidin B (MB) is a potent inducer of ROS-mediated apoptosis in cancer, but its mechanism of action is poorly understood."( Macranthoidin B Modulates Key Metabolic Pathways to Enhance ROS Generation and Induce Cytotoxicity and Apoptosis in Colorectal Cancer.
Cui, W; Fan, X; Li, D; Rao, J; Shen, Q; Tou, F; Wang, H; Zhang, J; Zhang, Z; Zheng, Z, 2018)		2.64

Pharmacokinetics

ExcerptReferenceRelevance
" This developed method was subsequently successfully applied to pharmacokinetic profiles of the four saponins in rats."( Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation.
Chen, CY; Li, P; Qi, LW; Wen, XD; Yi, L, 2009)		0.6
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.23 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.24 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinic acid
(-)-quinic acid : The (-)-enantiomer of quinic acid.		2.0610
oleanolic acid
[no description available]		3.4570hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.1110D-glucopyranoseepitope;
mouse metabolite
pulsatilla saponin a
Pulsatilla saponin A: has antineoplastic activity; isolated from Pulsatilla chinensis; structure in first source. kalopanaxsaponin A : A triterpenoid saponin that is hederagenin attached to a 2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage. It has been isolated from the stem bark of Kalopanax pictus.		2.2110disaccharide derivative;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triterpenoid saponin		anti-inflammatory agent;
plant metabolite
s-adenosylhomocysteine
S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.. S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.		2.1710adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide		cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite
beta-hederin
beta-hederin: derived from beta-amyrin; other hederigenin based saponins are available		2.2110triterpenoid
caffeic acid
trans-caffeic acid : The trans-isomer of caffeic acid.		2.1110caffeic acidgeroprotector;
mouse metabolite
chlorogenic acid
caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.		2.7830cinnamate ester;
tannin		food component;
plant metabolite
luteolin
[no description available]		2.11103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
luteolin-7-glucoside
luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum. luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.		2.1110beta-D-glucoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		antioxidant;
plant metabolite
rutin
Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.		2.0610disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
isochlorogenic acid
[no description available]		2.1110quinic acid
selenium
Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.		2.610chalcogen;
nonmetal atom		micronutrient
beta-escin
[no description available]		3.4570
4,5-dicaffeoyl quinic acid
4,5-dicaffeoyl quinic acid: structure in first source		2.0610
dipsacoside b
dipsacoside B: from flowers of Lonicera macranthoides Hand		8.3160
ConditionIndicatedRelationship StrengthStudiesTrials
Colorectal Cancer
[description not available]		07.1710
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.1710
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0510