Compounds > lf 1695
Page last updated: 2024-11-06

lf 1695

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

LF 1695: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72226
CHEMBL ID35827
SCHEMBL ID10355571
MeSH IDM0135304

Synonyms (12)

Synonym
lf-1695
lf 1695
methanone, (5-amino-2-(4-methyl-1-piperidinyl)phenyl)(4-chlorophenyl)-
86187-86-2
[5-amino-2-(4-methyl-1-piperidyl)phenyl]-(4-chlorophenyl)methanone
CHEMBL35827
2-(4-methyl-1-piperidinyl)-5-aminophenyl-(4-chlorophenyl)methanone
DTXSID90235440
SCHEMBL10355571
lf1695
(5-amino-2-(4-methylpiperidin-1-yl)phenyl)(4-chlorophenyl)methanone
AKOS040747076

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID118306Maximal proliferation induced by the test compound in the presence of the mitogen-PHA ( stimulated blastogenesis) in Mice cells at a dose of 10 ug/mL1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID118305Maximal proliferation induced in the presence of the mitogen-Concanavalin A (stimulated blastogenesis) in mice cells dosed at 5 ug/mL1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID112123In vivo induction of Thyl+ antigen expression on murine bone marrow cells at the concentration of 7 uM(Fraction A).(Control group)1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID122471Percent of Thyl+ positive cells / spleen x 10 e6 in nude mice (in vivo)1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID118314Proliferation induced by the mitogen alone-PHA (control blastogenesis), in Mice cells at a dose of 10 ug/mL1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID118313Proliferation induced by the mitogen alone-Concanavalin A (control blastogenesis), in mice cells dosed at 5 ug/mL1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID118782Percent of restoration of T- cell markers in nude mice (in vivo)1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID118311Maximal proliferation induced in the presence of the mitogen-PWM ( stimulated blastogenesis) in Mice cells at a dose of 40 ug/mL1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID118319Proliferation induced by the mitogen alone-PWM (control blastogenesis), in Mice cells at a dose of 40 ug/mL1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID112125In vivo induction of Thyl+ antigen expression on murine bone marrow cells at the concentration of 7 uM(Fraction B).(Control group)1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID112126In vivo induction of Thyl+ antigen expression on murine bone marrow cells at the concentration of 7 uM(Fraction B).(treated)1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID112124In vivo induction of Thyl+ antigen expression on murine bone marrow cells at the concentration of 7 uM(Fraction A).(treated))1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID122470Percent of Thyl+ positive cells, in nude mice (in vivo)1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
AID118781Percent of restoration in nude mice (in vivo)1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
(Benzoylphenyl)piperidines: a new class of immunomodulators.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.18 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.38 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5,8,11,14-eicosatetraynoic acid
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).		1.9710long-chain fatty acid
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		1.9710benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
thymidine
[no description available]		1.9710pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9710acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		1.9710icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.3720prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
leukotriene b4
Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene B4 : A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.		1.9610dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
12-hydroxy-5,8,10,14-eicosatetraenoic acid
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)		1.9710
calcimycin
Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.		2.3820benzoxazole
piperidines
Piperidines: A family of hexahydropyridines.		4.4570
thymosin
Thymosin: Thymosin. A family of heat-stable, polypeptide hormones secreted by the thymus gland. Their biological activities include lymphocytopoiesis, restoration of immunological competence and enhancement of expression of T-cell characteristics and function. They have therapeutic potential in patients having primary or secondary immunodeficiency diseases, cancer or diseases related to aging.		1.9710
concanavalin a
Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Acquired Immune Deficiency Syndrome
[description not available]		02.8910
Acquired Immunodeficiency Syndrome
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.		02.8910
Schistosoma mansoni Infection
[description not available]		01.9710
Schistosomiasis mansoni
Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.		01.9710