Compounds > hbf 0259
Page last updated: 2024-11-10

hbf 0259

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Cross-References

ID SourceID
PubMed CID4165150
CHEMBL ID550956
SCHEMBL ID4351214
MeSH IDM0520613

Synonyms (12)

Synonym
CHEMBL550956
SCHEMBL4351214
7-(2-chloro-6-fluorophenyl)-5-(4-chlorophenyl)-1,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine
7-(2-chloro-6-fluoro-phenyl)-5-(4-chlorophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine
7-(2-chloro-6-fluorophenyl)-5-(4-chlorophenyl)-4,5,6,7-tetrahydro-tetrazolo[1,5-a]pyrimidine
7-(2-chloro-6-fluorophenyl)-5-(4-chlorophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine
hbf-0259
957011-15-3
MS-25795
CS-0108993
HY-126970
AKOS040748518

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The lead candidates, both 1a (PBHBV-001) and 3c (PBHBV-2-15), were well-tolerated in both normal and HBV-transgenic mice and exhibited acceptable pharmacokinetics and bioavailability in Sprague-Dawley rats."( Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
Block, TM; Clearfield, E; Cuconati, A; Goddard, C; Guo, H; Mills, C; Morrey, JD; Motter, NE; Xiao, T; Xu, X; Yu, W; Zhao, K, 2011)		0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (104)

Assay IDTitleYearJournalArticle
AID425288Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as inhibition of HBeAg secretion at 0.5 to 50 uM after 6 days by ELISA relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425517Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2(2.2.15) cells assessed as effect on viral intracellular single stranded DNA at 2 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425536Inhibition of intracellular double glycosylated gp36 form of medium HBsAg-hemagglutininin secretion in pTRE.MSHA carrying HBV M and S transfected human HepG2 cells at 4 uM after 48 hrs using anti-preS2 antibody by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425521Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral capsid DNA level at 4 uM after 6 days by DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425287Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 4 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425296Cytotoxicity against human HepDE19 cells after 6 days by MTT assay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425501Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 4 uM after 3 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425516Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2(2.2.15) cells assessed as effect on viral intracellular single stranded DNA at 4 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425311Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of intracellular double glycosylated gp36 form of medium HBsAg level at 2 to 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425285Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425293Cytotoxicity against human HepG2(2.2.15) cells after 6 days by MTT assay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425522Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral capsid DNA level at 2 uM after 6 days by DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425532Inhibition of extracellular double glycosylated gp36 form of medium HBsAg-hemagglutininin secretion in pTRE.MSHA carrying HBV M and S transfected human HepG2 cells at 4 uM after 48 hrs using anti-hemagglutininin antibody by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425302Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion after 6 days by densitometric analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612610Antiviral activity against adefovir-resistant Hepatitis B virus harboring polymerase N584T mutant in human HepG2 cells assessed as inhibition of HBsAg secretion by ELISA2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425513Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2(2.2.15) cells assessed as effect on viral intracellular relaxed circular DNA at 4 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID1072510Cytotoxicity against human HepG2.2.15 cells by MTT assay2014European journal of medicinal chemistry, Mar-21, Volume: 75A review of non-nucleoside anti-hepatitis B virus agents.
AID425515Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2(2.2.15) cells assessed as effect on viral intracellular single stranded DNA at 8 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612611Antiviral activity against adefovir-resistant Hepatitis B virus harboring polymerase A529V mutant in human HepG2 cells assessed as inhibition of HBsAg secretion by ELISA2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425502Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 4 uM after 3 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425312Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of intracellular singly glycosylated gp33 form of medium HBsAg level at 2 to 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425290Antiviral activity against Bovine viral diarrhea virus NADL infected in MDCK cells at 1 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425541Antiviral activity against Bovine viral diarrhea virus NADL infected in MDCK cells at 0.1 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425499Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 4 uM treated every 3 days measured after 18 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425520Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral capsid DNA level at 8 uM after 6 days by DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425495Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total large HBsAg secretion at 4 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425535Inhibition of extracellular single glycosylated gp33 form of medium HBsAg-hemagglutininin secretion in pTRE.MSHA carrying HBV M and S transfected human HepG2 cells at 4 uM after 48 hrs using anti-preS2 antibody by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612608Antiviral activity against lamivudine/telbivudine-resistant Hepatitis B virus harboring polymerase L528M and M552V mutant in human HepG2 cells assessed as inhibition of HBsAg secretion by ELISA2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425298Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 2 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425707Antiviral activity against Bovine viral diarrhea virus NADL infected in MDCK cells at 2 uM by plaque reduction assay relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425301Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion after 6 days by densitometric analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425314Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total small HBsAg secretion at 8 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425518Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral virion DNA level at 4 uM after 6 days by DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425514Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2(2.2.15) cells assessed as effect on viral intracellular relaxed circular DNA at 2 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425508Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as effect on viral intracellular relaxed circular DNA at 2 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425533Inhibition of extracellular single glycosylated gp33 form of medium HBsAg-hemagglutininin secretion in pTRE.MSHA carrying HBV M and S transfected human HepG2 cells at 4 uM after 48 hrs using anti-hemagglutininin antibody by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425703Antiviral activity against Herpes simplex virus type 1 K057 infected in african green monkey Vero cells at 0.01 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425500Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 4 uM treated every 3 days measured after 18 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425507Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as effect on viral intracellular relaxed circular DNA at 4 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425295Antiviral activity against Hepatitis B virus in human HepDE19 cells assessed as inhibition of HBsAg production after 6 days by ELISA2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425305Reduction of alpha-1-acid glycoprotein secretion in Hepatitis B virus infected human HepG2(2.2.15) cells at 2 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425540Antiviral activity against Herpes simplex virus type 1 K057 infected in african green monkey Vero cells at 0.1 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425307Reduction of alpha-1-antitrypsin secretion in Hepatitis B virus infected human HepG2(2.2.15) cells at 4 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612607Antiviral activity against entecavir-resistant Hepatitis B virus harboring polymerase L528M, M552V, T532G and S550I mutant in human HepG2 cells assessed as inhibition of HBsAg secretion by ELISA2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425496Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total large HBsAg secretion at 2 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425308Reduction of alpha-1-antitrypsin secretion in Hepatitis B virus infected human HepG2(2.2.15) cells at 2 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425706Antiviral activity against Bovine viral diarrhea virus NADL infected in MDCK cells at 4 uM by plaque reduction assay relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425289Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral virion DNA level at 8 uM after 6 days by DNA hybridization2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612656Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg secretion after 6 days by ELISA2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425309Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of intracellular glycosylated gp42 form of large HBsAg level at 2 to 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425503Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 4 uM treated every 3 days measured after 9 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425297Selectivity index, ratio of CC50 for human HepDE19 cells to EC50 for HBV2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425509Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as effect on viral intracellular single stranded DNA at 8 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425291Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425705Antiviral activity against Bovine viral diarrhea virus NADL infected in MDCK cells at 8 uM by plaque reduction assay relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612655Antiviral activity against wild-type Hepatitis B virus infected in human HepG2 cells assessed as inhibition of HBsAg secretion by ELISA2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425316Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total small HBsAg secretion at 2 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612609Antiviral activity against lamivudine/telbivudine-resistant Hepatitis B virus harboring polymerase M552I mutant in human HepG2 cells assessed as inhibition of HBsAg secretion by ELISA2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425537Inhibition of intracellular single glycosylated gp33 form of medium HBsAg-hemagglutininin secretion in pTRE.MSHA carrying HBV M and S transfected human HepG2 cells at 4 uM after 48 hrs using anti-preS2 antibody by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425504Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 4 uM treated every 3 days measured after 9 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425523Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral virion DNA level at 8 uM after 6 days by dot blot DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425306Reduction of alpha-1-antitrypsin secretion in Hepatitis B virus infected human HepG2(2.2.15) cells at 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425530Inhibition of intracellular glycosylated gp27 form of small HBsAg-hemagglutininin secretion in pNI2.SHA carrying HBV S transfected human HepG2 cells at 4 uM after 48 hrs by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425519Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral virion DNA level at 2 uM after 6 days by DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425299Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 4 uM after 6 days by densitometric analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425526Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral capsid DNA level at 8 uM after 6 days by dot blot DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425494Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total large HBsAg secretion at 8 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425300Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 4 uM after 6 days by densitometric analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425304Reduction of alpha-1-acid glycoprotein secretion in Hepatitis B virus infected human HepG2(2.2.15) cells at 4 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425524Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral virion DNA level at 4 uM after 6 days by dot blot DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425313Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of intracellular nonglycosylated p30 form of medium HBsAg level at 2 to 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425525Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral virion DNA level at 2 uM after 6 days by dot blot DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425303Reduction of alpha-1-acid glycoprotein secretion in Hepatitis B virus infected human HepG2(2.2.15) cells at 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425710Antiviral activity against Herpes simplex virus type 1 K057 infected in african green monkey Vero cells at 2 uM by plaque reduction assay relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425531Inhibition of intracellular nonglycosylated p24 form of small HBsAg-hemagglutininin secretion in pNI2.SHA carrying HBV S transfected human HepG2 cells at 4 uM after 48 hrs by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425315Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total small HBsAg secretion at 4 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425704Antiviral activity against Herpes simplex virus type 1 K057 infected in african green monkey Vero cells at 0.001 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425491Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total medium HBsAg secretion at 8 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID612654Cytotoxicity against human HepG2(2.2.15) cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
AID425510Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as effect on viral intracellular single stranded DNA at 4 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425492Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total medium HBsAg secretion at 4 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425286Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 2 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425511Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as effect on viral intracellular single stranded DNA at 2 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425529Inhibition of extracellular small HBsAg-hemagglutininin secretion in pNI2.SHA carrying HBV S transfected human HepG2 cells at 4 uM after 48 hrs by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425702Antiviral activity against Bovine viral diarrhea virus NADL infected in MDCK cells at 0.001 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425506Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as effect on viral intracellular relaxed circular DNA at 8 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425294Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 4 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425497Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of large HBsAg secretion at 4 uM treated every 3 days measured after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425528Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral capsid DNA level at 2 uM after 6 days by dot blot DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425512Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2(2.2.15) cells assessed as effect on viral intracellular relaxed circular DNA at 8 uM after 6 days by Southern blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425493Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of total medium HBsAg secretion at 2 uM after 6 days by dot blot enzyme immunoassay2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425527Antiviral activity against Hepatitis B virus in tetracycline pretreated human HepG2 cells assessed as decrease in extracellular viral capsid DNA level at 4 uM after 6 days by dot blot DNA hybridization analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425534Inhibition of extracellular double glycosylated gp36 form of medium HBsAg-hemagglutininin secretion in pTRE.MSHA carrying HBV M and S transfected human HepG2 cells at 4 uM after 48 hrs using anti-preS2 antibody by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425701Antiviral activity against Bovine viral diarrhea virus NADL infected in MDCK cells at 0.01 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425310Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of intracellular nonglycosylated p39 form of large HBsAg level at 2 to 8 uM after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425498Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as reduction of medium HBsAg secretion at 4 uM treated every 3 days measured after 6 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425505Reduction of alpha-1-acid glycoprotein secretion in Hepatitis B virus infected human HepG2(2.2.15) cells at 4 uM treated every 3 days measured after 24 days by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425709Antiviral activity against Herpes simplex virus type 1 K057 infected in african green monkey Vero cells at 4 uM by plaque reduction assay relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425539Antiviral activity against Herpes simplex virus type 1 K057 infected in african green monkey Vero cells at 1 multiplicity of infection assessed as protection against virus-induced cytopathogenic effect at 5 uM relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425538Inhibition of intracellular nonglycosylated p30 form of medium HBsAg-hemagglutininin secretion in pTRE.MSHA carrying HBV M and S transfected human HepG2 cells at 4 uM after 48 hrs using anti-preS2 antibody by Western blot analysis2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425708Antiviral activity against Herpes simplex virus type 1 K057 infected in african green monkey Vero cells at 8 uM by plaque reduction assay relative to control2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID425292Antiviral activity against Hepatitis B virus in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 6 days by ELISA2007Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
protocatechualdehyde
protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure		3.1910dihydroxybenzaldehyde
aloe emodin
aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.		3.1910aromatic primary alcohol;
dihydroxyanthraquinone		antineoplastic agent;
plant metabolite
chrysophanic acid
chrysophanic acid: RN given refers to parent cpd; structure in Merck, 9th ed, #2260. chrysophanol : A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.		3.1910dihydroxyanthraquinoneanti-inflammatory agent;
antiviral agent;
plant metabolite
physcione
physcione: structure. physcion : A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.		3.1910dihydroxyanthraquinoneanti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite
nitazoxanide
nitazoxanide: a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug		3.1910benzamides;
carboxylic ester
lamivudine
[no description available]		3.1910monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
helioxanthin
helioxanthin: structure in first source. helioxanthin : A furonaphthodioxole that is furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one substituted by a 1,3-benzodioxol-5-yl group at posiiton 10. It is a inhibitor of HBV, HCV and HSV-1 viruses.		3.1910benzodioxoles;
furonaphthodioxole;
lignan		anti-HBV agent;
antineoplastic agent;
plant metabolite
chrysophanol 8-o-glucoside
chrysophanol 8-O-glucoside: has anti-hepatitis B virus activity; also has antiplatelet and anticoagulant activities; isolated from Rheum palmatum. chrysophanol 8-O-beta-D-glucoside : A beta-D-glucoside in which the aglycone species is chrysophanol, the glycosidic linkage being to the hydroxy group at C-8.		3.1910beta-D-glucoside;
monohydroxyanthraquinone
dihydrochelerythrine
dihydrochelerythrine: trypanocidal and antileishmanial dihydrochelerythrine derivative from Garcinia lucida; structure in first source		3.1910benzophenanthridine alkaloid
bay 41-4109
BAY 41-4109: structure in first source		3.1910
wogonin
wogonin: structure in first source. wogonin : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.		3.1910dihydroxyflavone;
monomethoxyflavone		angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite
helioxanthin 8-1
helioxanthin 8-1: an antiviral agent; structure in first source		3.1910
artesunate
artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether		3.1910artemisinin derivative;
cyclic acetal;
dicarboxylic acid monoester;
hemisuccinate;
semisynthetic derivative;
sesquiterpenoid		antimalarial;
antineoplastic agent;
ferroptosis inducer
leucamide a
leucamide A: a cytotoxic heptapeptide from the Australian sponge Leucetta microraphis; structure in first source		3.1910
astragaloside IV
[no description available]		3.1910pentacyclic triterpenoid;
triterpenoid saponin		anti-inflammatory agent;
antioxidant;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
neuroprotective agent;
plant metabolite;
pro-angiogenic agent
rosamultin
rosamultin: isolated from roots of Rosa multiflora; RN not in Chemline 3/87; RN from Chem Abstracts Index Guide 1985		3.1910
2-hydroxybenzoyl-n-(5-chlorothiazol-2-yl)amide
2-hydroxybenzoyl-N-(5-chlorothiazol-2-yl)amide: an antiviral agent effective against hepatitis B virus; structure in first source		3.1910
alisol f
[no description available]		3.1910
alisol a 24-acetate
alisol A 24-acetate: isolated from Alismatis Rhizoma; structure in first source		3.1910
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatitis B Virus Infection
[description not available]		03.420
Hepatitis B
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		03.420
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110