Compounds > hamacanthine a
Page last updated: 2024-11-10

hamacanthine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

hamacanthine A: a dihydropyrazinonediylbis(indole) alkaloid from deep-water marine sponge Hamacantha sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

hamacanthin A : A member of the class of pyrazinones that is 5,6-dihydropyrazin-2(1H)-one substituted at positions 3 and 6 by 6-bromo-1H-indol-3-yl groups. It is an antifungal drug isolated from deep water marine sponge Hamacantha sp. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3037568
CHEMBL ID219456
MeSH IDM0241140

Synonyms (5)

Synonym
160098-92-0
hamacanthine a
hamacanthin a
CHEMBL219456
(2s)-2,5-bis(6-bromo-1h-indol-3-yl)-2,3-dihydro-1h-pyrazin-6-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID337905Antifungal activity against Cryptococcus neoformans ATCC 32045 after 48 hrs by broth microdilution method1994Journal of natural products, Oct, Volume: 57, Issue:10
Hamacanthins A and B, new antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp.
AID274722Cytotoxicity against human HCT15 cell line2007Journal of natural products, Jan, Volume: 70, Issue:1
Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
AID337906Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by broth microdilution method1994Journal of natural products, Oct, Volume: 57, Issue:10
Hamacanthins A and B, new antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp.
AID274719Cytotoxicity against human SK-OV-3 cell line2007Journal of natural products, Jan, Volume: 70, Issue:1
Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
AID274718Cytotoxicity against human A549 cell line2007Journal of natural products, Jan, Volume: 70, Issue:1
Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
AID744543Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID337674Antifungal activity against Candida albicans ATCC 44506 after 24 hrs by broth microdilution method1994Journal of natural products, Oct, Volume: 57, Issue:10
Hamacanthins A and B, new antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp.
AID744544Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
AID274721Cytotoxicity against human XF498 cell line2007Journal of natural products, Jan, Volume: 70, Issue:1
Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
AID274720Cytotoxicity against human SK-MEL-2 cell line2007Journal of natural products, Jan, Volume: 70, Issue:1
Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
AID744538Antibacterial activity against Bacillus subtilis by CLSI method2013European journal of medicinal chemistry, May, Volume: 63Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0810aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0810aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		2.7130diazine;
pyrazines		Daphnia magna metabolite
topsentin
topsentin: structure given in first source; a marine natural product		2.1110
meropenem
Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.		2.0310alpha,beta-unsaturated monocarboxylic acid;
carbapenemcarboxylic acid;
organic sulfide;
pyrrolidinecarboxamide		antibacterial agent;
antibacterial drug;
drug allergen
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
[no description available]		2.0810
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0810antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Black Fever
[description not available]		02.0810
Leishmaniasis, Visceral
A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.		02.0810