Page last updated: 2024-12-06

topsentin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

topsentin: structure given in first source; a marine natural product [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	72457
CHEMBL ID	303282
SCHEMBL ID	19235593
MeSH ID	M0191245

Synonyms (15)

Synonym
topsentine b 1
methanone, (6-hydroxy-1h-indol-3-yl)(4-(1h-indol-3-yl)-1h-imidazol-2-yl)-
112515-43-2
topsentin
(6-hydroxy-1h-indol-3-yl)-[4-(1h-indol-3-yl)-1h-imidazol-2-yl]methanone
6-hydroxy-3-[(4-indol-3-ylimidazol-2-yl)carbonyl]indole
topsentin b1
CHEMBL303282 ,
(6-hydroxy-1h-indol-3-yl)-[5-(1h-indol-3-yl)-1h-imidazol-2-yl]methanone
TVPNFKRGOFJQOO-UHFFFAOYSA-N
bdbm50287721
(6-hydroxy-1h-indol-3-yl)-[5-(1h-indol-3-yl)-1h-imidazol-2-yl]-methanone
methanone,(6-hydroxy-1h-indol-3-yl)[5-(1h-indol-3-yl)-1h-imidazol-2-yl]-
DTXSID30150087
SCHEMBL19235593

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID1435526	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	2016	Journal of natural products, 11-23, Volume: 79, Issue:11	Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge.
AID401681	Cytotoxicity against human XF498 cells after 48 hrs by SRB assay	2005	Journal of natural products, May, Volume: 68, Issue:5	Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID379675	Cytotoxicity against human NSCLC-N6 cells by colorimetric assay	2000	Journal of natural products, Apr, Volume: 63, Issue:4	New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.
AID401678	Cytotoxicity against human A549 cells after 48 hrs by SRB assay	2005	Journal of natural products, May, Volume: 68, Issue:5	Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401692	Cytotoxicity against mouse P388 cells	2005	Journal of natural products, May, Volume: 68, Issue:5	Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401682	Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay	2005	Journal of natural products, May, Volume: 68, Issue:5	Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401679	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	2005	Journal of natural products, May, Volume: 68, Issue:5	Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401680	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay	2005	Journal of natural products, May, Volume: 68, Issue:5	Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (6.67)	18.2507
2000's	5 (33.33)	29.6817
2010's	6 (40.00)	24.3611
2020's	3 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	22.68 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	4.87 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (22.68)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thiazoles [no description available]	7.08	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	2.47	2	diazine; pyrazines	Daphnia magna metabolite
ribavirin Rebetron: Rebetron is tradename	2.13	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
imipenem, anhydrous Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.	2.02	1	beta-lactam antibiotic allergen; carbapenems; zwitterion	antibacterial drug
topsentin a topsentin A: number of carbony group = 1 for topsentin A and no carbonyl group for nortopsentin B and D; structure in first source	7.42	2
bromodeoxytopsentin bromodeoxytopsentin: from sponge Topsentia pachastrelloides; structure in first source. bromodeoxytopsentin : An aromatic ketone that is imidazole which is substituted by a 1H-indole-3-carbonyl group and a 6-bromo-1H-indol-3-yl group at positions 2 and 4, respectively. Isolated from the Mediterranean shallow-water sponge, Topsentia genetrix. It is a potent inhibitor of MRSA pyruvate kinase and exhibits antibacterial properties.	2.02	1	aromatic ketone; bromoindole; imidazoles; indole alkaloid	antibacterial agent; EC 2.7.1.40 (pyruvate kinase) inhibitor; marine metabolite
meropenem Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.	2.02	1	alpha,beta-unsaturated monocarboxylic acid; carbapenemcarboxylic acid; organic sulfide; pyrrolidinecarboxamide	antibacterial agent; antibacterial drug; drug allergen
hamacanthine a hamacanthine A: a dihydropyrazinonediylbis(indole) alkaloid from deep-water marine sponge Hamacantha sp.; structure in first source. hamacanthin A : A member of the class of pyrazinones that is 5,6-dihydropyrazin-2(1H)-one substituted at positions 3 and 6 by 6-bromo-1H-indol-3-yl groups. It is an antifungal drug isolated from deep water marine sponge Hamacantha sp.	2.11	1
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	2.72	2

Condition	Relationship Strength	Studies
Cancer of Pancreas [description not available]	2.31	1
Carcinoma, Ductal, Pancreatic [description not available]	2.31	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.31	1
Carcinoma, Pancreatic Ductal Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.	2.31	1
Infections, Pseudomonas [description not available]	2.31	1
Infections, Staphylococcal [description not available]	2.31	1
Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS.	2.31	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.31	1
Adult Spinal Muscular Atrophy [description not available]	2.17	1
Muscular Atrophy, Spinal A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)	2.17	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.97	1
B16 Melanoma [description not available]	1.97	1

chemdatabank.com