Page last updated: 2024-12-06

topsentin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

topsentin: structure given in first source; a marine natural product [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72457
CHEMBL ID303282
SCHEMBL ID19235593
MeSH IDM0191245

Synonyms (15)

Synonym
topsentine b 1
methanone, (6-hydroxy-1h-indol-3-yl)(4-(1h-indol-3-yl)-1h-imidazol-2-yl)-
112515-43-2
topsentin
(6-hydroxy-1h-indol-3-yl)-[4-(1h-indol-3-yl)-1h-imidazol-2-yl]methanone
6-hydroxy-3-[(4-indol-3-ylimidazol-2-yl)carbonyl]indole
topsentin b1
CHEMBL303282 ,
(6-hydroxy-1h-indol-3-yl)-[5-(1h-indol-3-yl)-1h-imidazol-2-yl]methanone
TVPNFKRGOFJQOO-UHFFFAOYSA-N
bdbm50287721
(6-hydroxy-1h-indol-3-yl)-[5-(1h-indol-3-yl)-1h-imidazol-2-yl]-methanone
methanone,(6-hydroxy-1h-indol-3-yl)[5-(1h-indol-3-yl)-1h-imidazol-2-yl]-
DTXSID30150087
SCHEMBL19235593
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1435526Cytotoxicity against human HeLa cells after 72 hrs by MTT assay2016Journal of natural products, 11-23, Volume: 79, Issue:11
Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge.
AID401681Cytotoxicity against human XF498 cells after 48 hrs by SRB assay2005Journal of natural products, May, Volume: 68, Issue:5
Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID379675Cytotoxicity against human NSCLC-N6 cells by colorimetric assay2000Journal of natural products, Apr, Volume: 63, Issue:4
New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.
AID401678Cytotoxicity against human A549 cells after 48 hrs by SRB assay2005Journal of natural products, May, Volume: 68, Issue:5
Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401692Cytotoxicity against mouse P388 cells2005Journal of natural products, May, Volume: 68, Issue:5
Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401682Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay2005Journal of natural products, May, Volume: 68, Issue:5
Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401679Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay2005Journal of natural products, May, Volume: 68, Issue:5
Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
AID401680Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay2005Journal of natural products, May, Volume: 68, Issue:5
Cytotoxic bisindole alkaloids from a marine sponge Spongosorites sp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's5 (33.33)29.6817
2010's6 (40.00)24.3611
2020's3 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.68 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.87 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.68)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]