Target type: molecularfunction
Combining with nicotinic acid to initiate a change in cell activity. [GOC:mah, PMID:12522134]
Nicotinic acid receptor activity refers to the ability of a protein to bind nicotine and other related compounds, leading to the opening of an ion channel. This activity is essential for neurotransmission, muscle contraction, and various other physiological processes. The molecular mechanism involves a conformational change in the receptor protein upon ligand binding. This change opens a channel through the cell membrane, allowing the passage of specific ions, most commonly sodium and calcium. The influx of these ions triggers a cascade of events, leading to the desired cellular response. For example, in the nervous system, the activation of nicotinic acetylcholine receptors at the neuromuscular junction leads to muscle contraction. Nicotinic receptors are also involved in regulating neuronal excitability, synaptic plasticity, and cognitive function. Mutations or dysfunction in nicotinic acid receptor activity can lead to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Hydroxycarboxylic acid receptor 3 | A hydroxycarboxylic acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49019] | Homo sapiens (human) |
| Hydroxycarboxylic acid receptor 2 | A hydroxycarboxylic acid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q8TDS4] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| niacin | Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms). | pyridine alkaloid; pyridinemonocarboxylic acid; vitamin B3 | antidote; antilipemic drug; EC 3.5.1.19 (nicotinamidase) inhibitor; Escherichia coli metabolite; human urinary metabolite; metabolite; mouse metabolite; plant metabolite; vasodilator agent |
| pyrazinoic acid | pyrazine-2-carboxylic acid : The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide. pyrazinoic acid: active metabolite of pyrazinamide; structure | pyrazinecarboxylic acid | antitubercular agent; drug metabolite |
| 3-hydroxybenzoic acid | 3-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3. It has been isolated from Taxus baccata. It is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc. 3-hydroxybenzoic acid: RN given refers to parent cpd | monohydroxybenzoic acid | bacterial metabolite; plant metabolite |
| alpha-resorcylic acid | 3,5-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 5. alpha-resorcylic acid: RN given refers to parent cpd | dihydroxybenzoic acid; resorcinols | metabolite |
| 5-methylpyrazole-3-carboxylic acid | 5-methyl-pyrazole-3-carboxylic acid : A memebr of the class of pyrazoles that is 1H-pyrazole with methyl and carboxylic acid group substituents at positions 5 and 3 respectively. 5-methylpyrazole-3-carboxylic acid: structure | monocarboxylic acid; pyrazoles | metabolite |
| 5-hydroxynicotinic acid | aromatic carboxylic acid; pyridines | ||
| acifran | acifran: structure given in first source | ||
| 5-bromonicotinic acid | 5-bromonicotinic acid: structure given in first source | ||
| 5-fluoro-3-pyridinecarboxylic acid | |||
| e-z cinnamic acid | cinnamic acid : A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia. trans-cinnamic acid : The E (trans) isomer of cinnamic acid | cinnamic acid | plant metabolite |
| trans-4-coumaric acid | 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid. | 4-coumaric acid | food component; mouse metabolite; plant metabolite |
| furanacrylic acid | |||
| 3-methyl-5-isoxazolecarboxylic acid | 3-methyl-5-isoxazolecarboxylic acid: N1 same as NM; RN given refers to parent cpd | ||
| 1-propan-2-yl-5-benzotriazolecarboxylic acid | benzotriazoles | ||
| acipimox | acipimox: lipolysis inhibitor | pyrazinecarboxylic acid | |
| ethyl fumarate | |||
| monomethyl fumarate | monomethyl fumarate : A dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. | dicarboxylic acid monoester; enoate ester; methyl ester | antioxidant; drug metabolite; immunomodulator |
| mk 0354 | |||
| gw9508 | GW9508: structure in first source | aromatic amine | |
| nitd 609 | NITD 609: an antimalarial and coccidiostat; structure in first source | ||
| mk 6892 | MK 6892: a niacin receptor agonist; structure in first source |