| AID1594681 | Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Indole Diterpenoids from an Endophytic Penicillium sp. |
| AID1055839 | Inhibition of Wnt/beta-catenin signaling pathway in human MDA-MB-231 cells assessed as decrease in expression of beta-catenin level at 19 uM after 48 hrs by DAPI staining-based confocal laser scanning microscopy | 2013 | European journal of medicinal chemistry, , Volume: 70 | Indole diterpene alkaloids as novel inhibitors of the Wnt/β-catenin pathway in breast cancer cells. |
| AID516676 | Inhibition of acetylcholinesterase at 100 ug/ml | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| Indoloditerpenes from an algicolous isolate of Aspergillus oryzae. |
| AID1700576 | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1122206 | Antimigratory activity in human MDA-MB-231 cells after 24 hrs by wound healing assay | 2013 | MedChemComm, Oct, Volume: 4, Issue:10
| Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. |
| AID1070514 | Displacement of [3H]-CP55940 from human CB1 receptor expressed in CHO cells | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. |
| AID1594680 | Cytotoxicity against mouse L5178Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Indole Diterpenoids from an Endophytic Penicillium sp. |
| AID516677 | Antibacterial activity against Escherichia coli at 30 ug/ml by agar diffusion test | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| Indoloditerpenes from an algicolous isolate of Aspergillus oryzae. |
| AID762954 | Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) PR/8 infected in MDCK cells assessed as protection against virus-induced cytopathogenicity after 48 hrs by crystal-violet staining-based assay | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7
| Indole-diterpenoids with anti-H1N1 activity from the aciduric fungus Penicillium camemberti OUCMDZ-1492. |
| AID1700577 | Antiviral activity against Zika virus Z16019 infected in human A549 cells assessed as reduction in viral titer preincubated for 1 hr followed by compound washout and subsequent compound addition without virus and measured after 48 hrs by plaque assay | | | |
| AID1122204 | In vivo inhibition of BK channel in L1 stage Caenorhabditis elegans N2 assessed as increase in reversals at 1 uM | 2013 | MedChemComm, Oct, Volume: 4, Issue:10
| Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. |
| AID1070512 | Antagonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 10 uM THC-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. |
| AID1122207 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | 2013 | MedChemComm, Oct, Volume: 4, Issue:10
| Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. |
| AID516675 | Toxicity in Artemia salina assessed as lethal rate at at 100 ug/mL | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| Indoloditerpenes from an algicolous isolate of Aspergillus oryzae. |
| AID1594683 | Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Indole Diterpenoids from an Endophytic Penicillium sp. |
| AID1122208 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2013 | MedChemComm, Oct, Volume: 4, Issue:10
| Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. |
| AID516925 | Antifungal activity against Colletotrichum lagenarium at 30 ug/ml by agar diffusion test | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| Indoloditerpenes from an algicolous isolate of Aspergillus oryzae. |
| AID1700578 | Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay | | | |
| AID1055848 | Inhibition of wild type L4 larval stage of Caenorhabditis elegans N2 bristol BK channel assessed as induction of reversal locomotion at 1 uM after 42 hrs | 2013 | European journal of medicinal chemistry, , Volume: 70 | Indole diterpene alkaloids as novel inhibitors of the Wnt/β-catenin pathway in breast cancer cells. |
| AID1070510 | Antagonist activity at human GPR55 expressed in CHO cells assessed as inhibition of LPI-mediated beta-arrestin recruitment at 10 uM after 90 mins by beta-galactosidase reporter gene assay relative to control | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. |
| AID1070513 | Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. |
| AID1594684 | Selectivity index, ratio of IC50 for HEK293 cells to IC50 for human A2780 cells | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Indole Diterpenoids from an Endophytic Penicillium sp. |
| AID516679 | Antifungal activity against Fusarium oxysporum at 30 ug/ml by agar diffusion test | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| Indoloditerpenes from an algicolous isolate of Aspergillus oryzae. |
| AID1070509 | Antagonist activity at human GPR55 expressed in CHO cells assessed as inhibition of LPI-mediated beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay | 2014 | Journal of natural products, Mar-28, Volume: 77, Issue:3
| Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. |
| AID1594682 | Cytotoxicity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by high content analysis based fluorescent live/dead assay | 2019 | Journal of natural products, 06-28, Volume: 82, Issue:6
| Indole Diterpenoids from an Endophytic Penicillium sp. |
| AID1122202 | Toxicity in L1 stage Caenorhabditis elegans N2 assessed as viability and reproduction at 50 uM | 2013 | MedChemComm, Oct, Volume: 4, Issue:10
| Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. |
| AID1122203 | Toxicity in L1 stage Caenorhabditis elegans N2 assessed as viability and reproduction at 10 uM | 2013 | MedChemComm, Oct, Volume: 4, Issue:10
| Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |