| Assay ID | Title | Year | Journal | Article |
|---|
| AID37210 | Displacement of [3H]prazosin from Alpha-1B adrenergic receptor of rat liver membrane | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID232476 | Selectivity ratio for binding affinity towards alpha2 and alpha-1 adrenoceptors | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID5253 | Compound is evaluated for binding affinity towards 5-hydroxytryptamine 2 receptor using [3H]ketanserin in rat brain | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID187034 | Blood pressure lowering activity in spontaneously hypertensive rats (SHR) after 1 hour of administration (iv) of dose of 0.5 mg/kg; Did not last more than 1/2 hr (in vitro) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. |
| AID4049 | Compound is evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-8-OH- -DPAT in rat brain cortex | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID36200 | Displacement of clonidine from Alpha-2 adrenergic receptor of rat cortical membranes | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID203839 | Binding affinity towards Sigma 2 receptor using [3H]ifenprodil in rat brain | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID64144 | Compound is evaluated for binding affinity towards Dopamine receptor D2 using [3H]spiperone in CHO cells | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID86741 | Compound is evaluated for binding affinity towards Histamine H1 receptor using [3H]pyrilamine in guinea pig lung | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID231272 | Ratio of binding affinity against alpha-2 adrenoceptor to that of alpha-1 adrenoceptor | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. |
| AID36214 | Compound is evaluated for binding affinity towards Alpha-2B adrenergic receptor using [3H]prazosin at 10 uM | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID63072 | Compound is evaluated for binding affinity towards recombinant human Dopamine receptor D2 using [3H]spiperone in CHO cells | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID36117 | Displacement of [3H]-prazosin from Alpha-1 adrenergic receptor of rat cortical membranes | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID205278 | Displacement of [3H]batrachotoxin from rat brain sodium channel at 10 uM | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID36597 | Displacement of [3H]prazosin from Alpha-1A adrenergic receptor of rat submaxillary gland membranes | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID3677 | Compound is evaluated for binding affinity towards 5-hydroxytryptamine 1 receptor using [3H]5-HT in rat brain cortex at 10 uM | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID35927 | Compound is evaluated for binding affinity towards Alpha-2A adrenergic receptor using [3H]prazosin at 10 uM | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID37295 | Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro). | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. |
| AID204463 | Compound is evaluated for binding affinity towards Sigma receptor using [3H]pentazocine in guinea pig brain | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| AID37077 | Binding affinity against alpha-2 adrenergic receptor by measuring displacement of [3H]clonidine from rat brain cortex membranes (in vitro). | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. |
| AID187045 | Blood pressure lowering activity in spontaneously hypertensive rats (SHR) after 6 hours of administration (iv) of dose of 0.5 mg/kg; Did not last more than 1/2 hr (in vitro) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. |
| AID65124 | Compound is evaluated for binding affinity towards recombinant human Dopamine receptor D3 using [3H]spiperone in CHO cells | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17
| Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |