biotin binding

Definition

Target type: molecularfunction

Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. [GOC:jl, ISBN:0198506732]

Biotin binding is a molecular function that describes the ability of a protein or enzyme to interact with the vitamin biotin. Biotin, also known as vitamin B7, is an essential cofactor for several key metabolic enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid metabolism. These enzymes, including carboxylase enzymes, rely on biotin to carry out their catalytic functions. Biotin binding occurs through a specific interaction between the biotin molecule and a conserved amino acid sequence within the biotin-binding site of the enzyme. This interaction typically involves hydrogen bonding and hydrophobic interactions, leading to the formation of a stable complex between the enzyme and biotin. The binding of biotin to the enzyme is essential for its catalytic activity. Biotin acts as a carrier of carbon dioxide during the enzymatic reactions, facilitating the transfer of a carboxyl group from one molecule to another. The binding of biotin to the enzyme is highly specific, ensuring that the correct cofactor is utilized for the enzymatic reaction. This specificity is achieved through the unique structural features of the biotin-binding site, which can only accommodate biotin.'
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Proteins (2)

Compounds (3)