| Assay ID | Title | Year | Journal | Article |
|---|
| AID1486143 | Inhibition of VEGFR2 phosphorylation in human MDA-MB-231 cells at 20 uM by Western blot analysis | | | |
| AID1713692 | Effect on total c-Met level in human MDA-MB-231 cells at 25 to 50 microM measured after 72 hrs in presence of HGF by immunoblot analysis | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1713690 | Antiinvasive activity against human BT-474 cells measured after 24 hrs by Calcein AM dye based fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID761302 | Toxicity in Sprague-Dawley rat hippocampal slice at 10 uM measured after 1 hr by electrophysiological assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
| Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling. |
| AID1713691 | Inhibition of c-MET kinase domain (unknown origin) using Tyr6 peptide as substrate measured after 1 hr in presence of ATP by Z'-lyte kinase assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1713683 | Antimigratory activity against human SK-BR-3 cells assessed as inhibition of HGF-mediated cell migration measured up to 24 hrs by wound healing assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486137 | Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as reduction in tumor size at 40 mg/kg, ip administered thrice per week for 20 days measured on day 30 relative to control | | | |
| AID1486165 | Effect on total VEGFR2 protein level in human MDA-MB-231 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1486163 | Antiangiogenic activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as reduction in CD31 levels in tumor at 40 mg/kg, ip administered thrice per week for 20 days measured at 3 hrs post last dose by immunohistochemical stainin | | | |
| AID1486156 | Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as reduction in Akt phosphorylation at 20 to 50 uM by Western blot analysis | | | |
| AID1713721 | Inhibition of human PKC assessed as inhibition of TPA-stimulated human 47kDa platelet protein phosphorylation | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486154 | Inhibition of VEGFR2 in human BT474 cells assessed as downregulation of phosphorylated FAK levels at 50 uM by Western blot analysis | | | |
| AID1713678 | Antiproliferative activity against ER-positive human BT-474 cells overexpressing HER2 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID761305 | Neuroprotective activity in Sprague-Dawley rat hippocampal slice assessed as reversal of DFP-induced damage at 10 uM compound treated 30 mins post DFP-challenge measured after 1 hr by electrophysiological assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
| Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling. |
| AID1486145 | Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as downregulation of phosphorylated FAK levels at 20 uM by Western blot analysis | | | |
| AID1486142 | Antiproliferative activity against human BT474 cells by MTT assay | | | |
| AID1713681 | Antimigratory activity against human MDA-MB-231 cells overexpressing c-Met assessed as inhibition of HGF-mediated cell migration measured after 23 hrs by wound healing assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1713673 | Antiproliferative activity against estrogen-dependent human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID327674 | Inhibition of TPA-stimulated phosphorylation of 47K-Da human platelet protein | 2008 | Journal of natural products, Jan, Volume: 71, Issue:1
| Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol. |
| AID1486139 | In vivo inhibition of VEGFR2 phosphorylation in athymic nude mouse tumor homogenate xenografted with human MDA-MB-231 cells at 40 mg/kg, ip administered thrice per week for 20 days by Western blot analysis relative to control | | | |
| AID1713679 | Antimigratory activity against human MCF7 cells assessed as inhibition of HGF-mediated cell migration measured up to 24 hrs by wound healing assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486176 | Effect on total Akt protein level in human MDA-MB-231 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1713712 | Reduction in papilloma incidence in mouse at 3.3 uM administered 40 mins prior to TPA treatment | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1713717 | Antiinvasive activity against human MDA-MB-231 cells overexpressing c-Met assessed as inhibition of cell invasion at 40 uM measured after 24 hrs by Calcein AM dye based fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486138 | Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as reduction in tumor size at 40 mg/kg, ip administered thrice per week for 20 days measured on day 24 relative to control | | | |
| AID327673 | Effect on TPA-induced skin tumor promotion in human HeLa cells assessed as inhibition of 32Pi incorporation into phospholipids at 3.3 uM after 40 mins | 2008 | Journal of natural products, Jan, Volume: 71, Issue:1
| Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol. |
| AID1486159 | Toxicity in athymic nude mouse xenografted with human MDA-MB-231 cells assessed as body weight loss at 40 mg/kg, ip administered thrice per week for 20 days measured daily during compound dosing | | | |
| AID1713674 | Antiproliferative activity against estrogen-dependent human T47D cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID327672 | Inhibition of TPA-induced skin tumor promotion in mouse assessed as reduction in number of skin papillomas at 3.3 uM after 40 mins | 2008 | Journal of natural products, Jan, Volume: 71, Issue:1
| Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol. |
| AID1486150 | Inhibition of VEGFR2 in human BT474 cells assessed as downregulation of phosphorylated paxillin levels at 20 uM by Western blot analysis | | | |
| AID1486170 | Effect on total FAK protein level in human BT474 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1486148 | Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as downregulation of phosphorylated FAK levels at 50 uM by Western blot analysis | | | |
| AID1713720 | Inhibition of 32Pi incorporation in phospholipids of TPA-stimulated human HeLa cells at 50 uM | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486146 | Inhibition of VEGFR2 phosphorylation in human MDA-MB-231 cells at 50 uM by Western blot analysis | | | |
| AID1486160 | Toxicity in athymic nude mouse xenografted with human MDA-MB-231 cells assessed as lethargy at 40 mg/kg, ip administered thrice per week for 20 days measured daily during compound dosing | | | |
| AID1713682 | Antimigratory activity against human MDA-MB-468 cells assessed as inhibition of HGF-mediated cell migration measured up to 24 hrs by wound healing assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486151 | Inhibition of VEGFR2 in human BT474 cells assessed as downregulation of phosphorylated FAK levels at 20 uM by Western blot analysis | | | |
| AID1486178 | Drug uptake in athymic nude mouse serum at 40 mg/kg, ip after 2 hrs by ES-MS analysis | | | |
| AID1486173 | Effect on total PI3K protein level in human BT474 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1713688 | Antiinvasive activity against human MDA-MB-468 cells measured after 24 hrs by Calcein AM dye based fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486147 | Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as downregulation of phosphorylated paxillin levels at 50 uM by Western blot analysis | | | |
| AID1713684 | Antimigratory activity against human BT-474 cells assessed as inhibition of HGF-mediated cell migration measured up to 24 hrs by wound healing assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486174 | Effect on total Akt protein level in human BT474 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1486140 | Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as reduction in formation of blood vessel red batches in tumor at 40 mg/kg, ip administered thrice per week for 20 days | | | |
| AID1486177 | Effect on total VEGFR2 protein level in athymic nude mouse tumor homogenate xenografted with human MDA-MB-231 cells at 40 mg/kg, ip administered thrice per week for 20 days by Western blot analysis relative to control | | | |
| AID1713675 | Antiproliferative activity against triple-negative human MDA-MB-231 cells overexpressing c-Met assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1713677 | Antiproliferative activity against ER-deficient human SK-BR-3 cells overexpressing HER2 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486175 | Effect on total PI3K protein level in human MDA-MB-231 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1486169 | Effect on total paxillin protein level in human BT474 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1713687 | Antiinvasive activity against human MDA-MB-231 cells overexpressing c-Met assessed as inhibition of cell invasion measured after 24 hrs by Calcein AM dye based fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486158 | Cytotoxicity against rat RSC96 cells by MTT assay | | | |
| AID1486167 | Effect on total FAK protein level in human MDA-MB-231 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1713689 | Antiinvasive activity against human SK-BR-3 cells measured after 24 hrs by Calcein AM dye based fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486161 | Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor volume at 40 mg/kg, ip administered thrice per week for 20 days (Rvb = 1870 +/- 194.9 mm3) | | | |
| AID1486168 | Effect on total VEGFR2 protein level in human BT474 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1713676 | Antiproliferative activity against triple-negative human MDA-MB-468 cells overexpressing c-Met assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486172 | Inhibition of VEGFR2 in human BT474 cells assessed as reduction in Akt phosphorylation at 20 to 50 uM by Western blot analysis | | | |
| AID1486164 | Antiangiogenic activity in matrigel injected Swiss albino mouse assessed as reduction in hemoglobin content in matrigel plug at 40 mg/kg, ip every other day for 20 days by matrigel assay | | | |
| AID1486149 | Inhibition of VEGFR2 phosphorylation in human BT474 cells at 20 uM by Western blot analysis | | | |
| AID1486157 | Cytotoxicity against human MCF12A cells by MTT assay | | | |
| AID1486153 | Inhibition of VEGFR2 in human BT474 cells assessed as downregulation of phosphorylated paxillin levels at 50 uM by Western blot analysis | | | |
| AID1486144 | Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as downregulation of phosphorylated paxillin levels at 20 uM by Western blot analysis | | | |
| AID1486152 | Inhibition of VEGFR2 phosphorylation in human BT474 cells at 50 uM by Western blot analysis | | | |
| AID327675 | Antiproliferative activity against mouse +SA mammary epithelial cells at 15 to 40 uM after 4 days by MTT assay | 2008 | Journal of natural products, Jan, Volume: 71, Issue:1
| Semisynthetic and biotransformation studies of (1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol. |
| AID1486171 | Inhibition of VEGFR2 in human BT474 cells assessed as reduction in PI3K phosphorylation at 20 to 50 uM by Western blot analysis | | | |
| AID1486179 | Drug metabolism in athymic nude mouse serum assessed as monohydroxylated metabolite formation at 40 mg/kg, ip after 2 hrs by ES-MS analysis | | | |
| AID1713685 | Antiinvasive activity against human MCF7 cells measured after 24 hrs by Calcein AM dye based fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486166 | Effect on total paxillin protein level in human MDA-MB-231 cells at 20 to 50 uM by Western blot analysis | | | |
| AID1486180 | Drug metabolism in athymic nude mouse serum assessed as dihydroxylated metabolite formation at 40 mg/kg, ip after 2 hrs by ES-MS analysis | | | |
| AID761303 | Neuroprotective activity in Sprague-Dawley rat hippocampal slice assessed as reversal of DFP-induced damage at 10 uM measured after 2 hrs by electrophysiological assay | 2013 | Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
| Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling. |
| AID1713686 | Antiinvasive activity against human T47D cells measured after 24 hrs by Calcein AM dye based fluorescence assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486155 | Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as reduction in PI3K phosphorylation at 20 to 50 uM by Western blot analysis | | | |
| AID1713693 | Inhibition of c-MET in human MDA-MB-231 cells assessed as downregulation of activated phosphorylated c-MET level measured after 72 hrs in presence of HGF by immunoblot analysis | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1713680 | Antimigratory activity against human T47D cells assessed as inhibition of HGF-mediated cell migration measured up to 24 hrs by wound healing assay | 2016 | Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
| (1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies. |
| AID1486162 | Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as reduction in tumor size at 40 mg/kg, ip administered thrice per week for 20 days measured on day 27 relative to control | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |