| Assay ID | Title | Year | Journal | Article |
|---|
| AID1528874 | Neuroprotective activity against oxygen-glucose deprivation-induced toxicity in human SH-SY5Y cells assessed as cell viability at 10 uM preincubated for 2 hrs followed by OGD-challenge and measured after 24 hrs by MTT assay (Rvb = 54.92 +/- 2.12%) | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Development of Novel |
| AID1884113 | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero cells to EC50 for antiviral activity against HSV-2 infected in African green monkey Vero cells | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID748428 | Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. |
| AID1884121 | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells at 10 uM incubated for 2 hrs | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID748426 | Selectivity ratio of Ki for wild type IDH1 (unknown origin) to Ki for recombinant IDH1 R132H mutant (unknown origin) | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. |
| AID1366997 | Inhibition of IDH1 R132C mutant (unknown origin) | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
| Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1. |
| AID1366998 | Inhibition of human N-terminal Strep-tagged IDH1 R132H mutant expressed in Escherichia coli BL21(DE3) using alphaKG as substrate preincubated for 30 mins in presence of NADPH followed by substrate addition by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
| Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1. |
| AID1884111 | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTS assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1884118 | Half life in mouse liver microsomes at 2 uM in presence of NADPH by LC/MS/MS analysis | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1884120 | Apparent permeability of the compound across apical to basolateral side in human Caco-2 cells at 10 uM incubated for 2 hrs | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1884119 | Half life in human liver microsomes at 2 uM in presence of NADPH by LC/MS/MS analysis | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1167100 | Selectivity index, ratio of EC50 for mouse BXD4687 cells to EC50 for human BT142 cells | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1167087 | Inhibition of human IDH1 R132C mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumption | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1167094 | Inhibition of neurosphere formation of mouse BXD4687 cells by CCK8 assay | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID748422 | Inhibition of IDH1 R132C mutant in human HT1080 cells assessed as production of D-2-hydroxyglutaric acid formation after 48 hrs by HPLC-MS method | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. |
| AID748425 | Inhibition of wild type IDH1 (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. |
| AID1884107 | Antiviral activity against HSV-1 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 5 uM incubated for 1 hr followed by washing with PBS and subsequent | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1167091 | Permeability from basolateral to apical side in MDCK cells expressing MDR1 at 10 uM incubated at 37 degC for 90 mins by LC/MS/MS method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1167088 | Cytotoxicity against human HT1080 cells up to 30 uM | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1167092 | Efflux ratio, ratio of permeability from basolateral side over apical to basolateral side in MDCK cells expressing MDR1 at 10 uM incubated at 37 degC for 90 mins by LC/MS/MS method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1167099 | Selectivity index, ratio of EC50 for mouse BXD3752 cells to EC50 for human BT142 cells | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1528873 | Neuroprotective activity against oxygen-glucose deprivation-induced toxicity in human SH-SY5Y cells assessed as cell viability at 1 uM preincubated for 2 hrs followed by OGD-challenge and measured after 24 hrs by MTT assay (Rvb = 54.92 +/- 2.12%) | 2020 | Journal of medicinal chemistry, 02-13, Volume: 63, Issue:3
| Development of Novel |
| AID748424 | Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTS assay | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. |
| AID1366999 | Inhibition of human N-terminal Strep-tagged IDH1 R132C mutant expressed in Escherichia coli BL21(DE3) using alphaKG as substrate preincubated for 30 mins in presence of NADPH followed by substrate addition by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry, 12-15, Volume: 25, Issue:24
| Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1. |
| AID748427 | Inhibition of recombinant IDH1 R132C mutant (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. |
| AID1884105 | Antiviral activity against HSV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 5 uM incubated for 1 hr followed by washing with PBS and subsequent | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1884108 | Antiviral activity against HSV-1 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 1 uM incubated for 1 hr followed by washing with PBS and subsequent | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1884106 | Antiviral activity against HSV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 1 uM incubated for 1 hr followed by washing with PBS and subsequent | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1167093 | Inhibition of neurosphere formation of human BT142 cells by CCK8 assay | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1884104 | Antiviral activity against HSV-2 333vhsB infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring reduction in virus-induced cytopathic effect at 50 uM incubated for 20 hrs by colorimetric analysis | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1167085 | Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumption | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID748423 | Selectivity ratio of Ki for wild type IDH1 (unknown origin) to Ki for recombinant IDH1 R132C mutant (unknown origin) | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. |
| AID1167096 | Inhibition of cell proliferation of human WI38 cells by CCK8 assay | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1884114 | Selectivity index, ratio of CC50 for cytotoxicity against human HepDES19 cells to EC50 for antiviral activity against HSV-2 infected in African green monkey Vero cells | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1167089 | Permeability from apical to basolateral side in MDCK cells expressing MDR1 at 10 uM incubated at 37 degC for 90 mins by LC/MS/MS method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1167086 | Inhibition of wild type human IDH1 expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumption | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1884112 | Cytotoxicity against human HepDES19 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| AID1167090 | Inhibition of IDH1 R132C mutant in human HT1080 cells assessed as reduction in D2HG production incubated for 48 hrs by HPLC-MS method | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1167095 | Inhibition of neurosphere formation of mouse BXD3752 cells by CCK8 assay | 2014 | Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20
| Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. |
| AID1884110 | Antiviral activity against HSV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque reduction assay | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |