SYC-435 has been researched along with Herpes-Simplex* in 1 studies
1 other study(ies) available for SYC-435 and Herpes-Simplex
| Article | Year |
|---|---|
Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2.
We previously showed that the anti-fungal drug ciclopirox olamine effectively inhibits replication of herpes simplex virus (HSV)-1 and HSV-2. Given the rise of HSV strains that are resistant to nucleos(t)ide analog treatment, as well as the incomplete efficacy of nucleos(t)ide analogs, new inhibitory compounds must be explored for potential use in the treatment of HSV infection. In the present study, we analyzed 44 compounds derived from the core structure of ciclopirox olamine for inhibitory activity against HSV. Thirteen of these derivative compounds inhibited HSV-2 replication by > 1000- to ∼100,000-fold at 1 μM and displayed EC Topics: Acyclovir; Antifungal Agents; Antiviral Agents; Ciclopirox; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Virus Replication | 2022 |