1-deoxy-D-xylulose 5-phosphate biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. [GOC:curators]

The 1-deoxy-D-xylulose 5-phosphate (DXP) biosynthetic process is a crucial metabolic pathway in many organisms, particularly bacteria, plants, and some protists. It serves as the starting point for the synthesis of essential isoprenoid compounds, including carotenoids, ubiquinones, and sterols, all of which play vital roles in various cellular processes.

The pathway begins with the condensation of pyruvate and D-glyceraldehyde 3-phosphate (G3P) catalyzed by the enzyme DXP synthase. This reaction forms 1-deoxy-D-xylulose 5-phosphate (DXP), the namesake molecule of the pathway. Subsequent enzymatic steps involve the conversion of DXP to MEP (2-C-methyl-D-erythritol 4-phosphate), another crucial intermediate.

The DXP biosynthetic pathway is a complex series of enzymatic reactions that are tightly regulated. It is often targeted by herbicides and antibiotics due to its essential role in the production of isoprenoids. This pathway is absent in animals, making it an attractive target for selective inhibition.'
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Proteins (1)

Compounds (4)