pyridoxine biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. [GOC:ai]

The pyridoxine biosynthetic process is a complex metabolic pathway that produces pyridoxine, also known as vitamin B6. This essential vitamin plays a critical role in numerous metabolic reactions, including amino acid metabolism, carbohydrate metabolism, and neurotransmitter synthesis. The biosynthesis of pyridoxine occurs in plants and some microorganisms, but not in animals, hence the need for dietary intake. The pathway begins with the conversion of D-erythrose 4-phosphate, a sugar derived from the pentose phosphate pathway, and D-glyceraldehyde 3-phosphate, a product of glycolysis, into 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP). DAHP is then converted to 3-deoxy-7-phospho-D-arabino-heptulosonate 7-phosphate (DAHP-7-phosphate) through the action of the enzyme 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. DAHP-7-phosphate is then transformed into 5-dehydroquinate (DHQ) by the enzyme 3-dehydroquinate synthase. DHQ is then converted to 5-dehydroshikimate (DHS) by the enzyme 5-dehydroquinate dehydratase. DHS is then transformed into shikimate by the enzyme 5-dehydroshikimate reductase. Shikimate is then converted into chorismate by a series of enzymatic reactions. Chorismate is a key intermediate in the biosynthesis of several aromatic compounds, including tryptophan, tyrosine, and phenylalanine. In the pyridoxine biosynthetic pathway, chorismate is converted into 4-hydroxybenzoate by the enzyme chorismate mutase. 4-hydroxybenzoate is then transformed into p-aminobenzoate (PABA) by the enzyme 4-hydroxybenzoate decarboxylase. PABA is then converted into pyridoxine by a series of enzymatic reactions. The biosynthesis of pyridoxine is tightly regulated, ensuring that the body produces adequate amounts of this essential vitamin while avoiding excessive accumulation.'
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Proteins (1)

Compounds (4)