dimethylargininase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. [EC:3.5.3.18]
Dimethylargininase activity is a hydrolytic enzymatic activity that specifically catalyzes the conversion of asymmetric dimethylarginine (ADMA) to citrulline and dimethylamine. ADMA is a naturally occurring amino acid that acts as a potent inhibitor of nitric oxide synthase (NOS), the enzyme responsible for the production of nitric oxide (NO). NO is a signaling molecule involved in numerous physiological processes, including vasodilation, neurotransmission, and immune function. By hydrolyzing ADMA, dimethylargininase activity reduces the levels of this NOS inhibitor, thereby increasing NO production. This enzymatic activity plays a crucial role in the regulation of NO signaling and has been implicated in a variety of biological processes, including cardiovascular health, inflammation, and cancer. The enzyme responsible for this activity is known as dimethylarginine dimethylaminohydrolase (DDAH), and it exists in two isoforms, DDAH1 and DDAH2. These isoforms exhibit tissue-specific expression patterns and play distinct roles in regulating NO signaling. For example, DDAH1 is primarily expressed in the liver, while DDAH2 is found in various tissues, including the brain, heart, and blood vessels. The precise regulation of dimethylargininase activity is complex and involves multiple factors, including substrate availability, enzyme phosphorylation, and interaction with other proteins. Understanding the molecular function of this activity is essential for comprehending the regulation of NO signaling and its implications for various biological processes.'
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Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of cow. [OMA:P56965, PRO:DNx] | Bos taurus (cattle) |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94760] | Homo sapiens (human) |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | An N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94760] | Homo sapiens (human) |
Compounds (18)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| lansoprazole | Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers. | benzimidazoles; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| omeprazole | 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole. Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. | aromatic ether; benzimidazoles; pyridines; sulfoxide | |
| pantoprazole | pantoprazole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a difluoromethoxy group at position 5 and a [(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl group at position 2. Pantoprazole: 2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER. | aromatic ether; benzimidazoles; organofluorine compound; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; environmental contaminant; xenobiotic |
| rabeprazole | Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. | benzimidazoles; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| citrulline | citrulline : The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position. | amino acid zwitterion; citrulline | Daphnia magna metabolite; EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; protective agent; Saccharomyces cerevisiae metabolite |
| 2-ethylbenzimidazole | |||
| 1,2-benzisothiazoline-3-one | 1,2-benzisothiazoline-3-one: a preservative in water-based solutions such as paints, cutting fluids, printing inks, cleaning agents, polyvinyl chloride gloves, etc. benzo[d]isothiazol-3-one : An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. | organic heterobicyclic compound; organonitrogen heterocyclic compound | disinfectant; drug allergen; environmental contaminant; platelet aggregation inhibitor; sensitiser; xenobiotic |
| homocysteine | homocysteine : A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain. Homocysteine: A thiol-containing amino acid formed by a demethylation of METHIONINE. L-homocysteine : A homocysteine that has L configuration. | amino acid zwitterion; homocysteine; serine family amino acid | fundamental metabolite; mouse metabolite |
| s-methylthiocitrulline | S-methyl-L-thiocitrulline : An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group. S-methylthiocitrulline: a nitric oxide synthase inhibitor; structure in first source | imidothiocarbamic ester; L-arginine derivative; L-ornithine derivative; non-proteinogenic L-alpha-amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor; neuroprotective agent |
| n(g)-iminoethylornithine | L-alpha-amino acid | ||
| n,n-dimethylarginine | N,N-dimethylarginine: asymmetric dimethylarginine; do not confuse with N,N'-dimethylarginine N(omega),N(omega)-dimethyl-L-arginine : A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group. | dimethylarginine; guanidines; L-arginine derivative; non-proteinogenic L-alpha-amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor |
| omega-n-methylarginine | N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent. omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase. | amino acid zwitterion; arginine derivative; guanidines; L-arginine derivative; non-proteinogenic L-alpha-amino acid | |
| delta-n-methylarginine | N(5)-methyl-L-arginine : A non-proteinogenic L-alpha-amino acid that is L-arginine substituted by a methyl group at N(5)-position. | guanidines; L-arginine derivative; non-proteinogenic L-alpha-amino acid | |
| nitroarginine | N(gamma)-nitro-L-arginine : An L-arginine derivative that is L-arginine in which the terminal nitrogen of the guanidyl group is replaced by a nitro group. Nitroarginine: An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6) | guanidines; L-arginine derivative; N-nitro compound; non-proteinogenic L-alpha-amino acid | |
| vinyl-l-nio | |||
| tenatoprazole | Tenatoprazole: structure in first source | imidazopyridine | |
| pd 404182 | |||
| omega-n-allylarginine | omega-N-allylarginine: inhibitor of nitric oxide synthase; structure given in first source |