1-salicylate glucuronide

Description

## 1-Salicylate Glucuronide: What it is and why it's important

**1-Salicylate glucuronide** is a **metabolite** of **salicylic acid**, the active ingredient in aspirin. It's formed in the liver via a process called **glucuronidation**, where a molecule of glucuronic acid is attached to salicylate.

**Here's why it's important for research:**

* **Pharmacokinetic studies:** Understanding the metabolism of salicylate is crucial for **determining the pharmacokinetic properties** of aspirin, such as its absorption, distribution, metabolism, and excretion. This knowledge is essential for optimizing drug dosage and minimizing side effects.

* **Toxicity studies:** Salicylate glucuronide formation is important for **understanding the toxicity of salicylate**. Since glucuronidation helps to detoxify salicylate, measuring levels of this metabolite can indicate the efficiency of the detoxification process and the potential for toxicity.

* **Disease research:** 1-Salicylate glucuronide levels can also be studied in the context of various diseases. For example, **reduced glucuronidation** has been linked to **liver disease** and **certain genetic disorders**, making it a potential biomarker for these conditions.

* **Clinical applications:** Measuring salicylate glucuronide levels in patients can help clinicians assess **the effectiveness of aspirin therapy** and monitor for potential toxicity. This is especially important for patients taking high doses of aspirin or those with compromised liver function.

* **Drug interactions:** Certain drugs can inhibit or induce glucuronidation, affecting the levels of 1-salicylate glucuronide and potentially impacting the efficacy and safety of aspirin therapy.

**Overall, 1-salicylate glucuronide is a valuable tool for researchers and clinicians seeking to understand the metabolism, toxicity, and clinical implications of aspirin. Its importance stems from its role in the detoxification of salicylate and its potential as a biomarker for various conditions.**

1-salicylate glucuronide: urinary metabolite of salicylic acid; RN given refers to (beta-D)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1-salicylate glucuronide : A beta-D-glucosiduronic acid that is the glucuronide conjugate of salicyclic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]