Page last updated: 2024-12-06

1-menaphthyl sulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

**1-Menaphthyl sulfate** is a synthetic compound that is a **substrate** for the enzyme **sulfotransferase**.

Here's a breakdown of its key features and importance in research:

**What is it?**

* **Chemical Structure:** 1-Menaphthyl sulfate is a sulfate ester of 1-naphthol. It has a naphthalene ring structure with a sulfate group attached at the 1-position.
* **Solubility:** It is soluble in water.
* **Stability:** It is relatively stable under normal laboratory conditions.

**Why is it important for research?**

* **Sulfotransferase Enzyme Activity:** 1-Menaphthyl sulfate is commonly used as a substrate in assays to measure the activity of sulfotransferases. Sulfotransferases are a family of enzymes that catalyze the transfer of a sulfate group from a donor molecule (like PAPS, 3'-phosphoadenosine 5'-phosphosulfate) to an acceptor molecule.
* **Drug Metabolism Research:** Sulfotransferases are involved in the metabolism of many drugs and other compounds. 1-Menaphthyl sulfate is useful for studying the activity of these enzymes and how they affect drug efficacy and toxicity.
* **Neurotransmitter Metabolism:** Sulfotransferases play a role in the metabolism of neurotransmitters like dopamine and serotonin. 1-Menaphthyl sulfate can be used to investigate the role of these enzymes in neurotransmission and neurological disorders.
* **Cancer Research:** Some sulfotransferases have been implicated in cancer development and progression. Studying these enzymes with substrates like 1-menaphthyl sulfate can provide insights into potential therapeutic targets.

**How it works:**

* In assays, 1-menaphthyl sulfate is incubated with a sample containing sulfotransferase enzymes and PAPS.
* The enzyme catalyzes the transfer of the sulfate group from PAPS to 1-menaphthyl sulfate, forming 1-naphthol.
* The amount of 1-naphthol produced is measured, which reflects the activity of the sulfotransferase enzyme.

**Overall, 1-menaphthyl sulfate is a valuable tool in research for studying sulfotransferase enzymes and their diverse roles in drug metabolism, neurotransmission, and other biological processes.**

1-menaphthyl sulfate: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID33524
MeSH IDM0052092

Synonyms (11)

Synonym
1-menaphthyl sulfate
1-methylnaphthyl sulfate
26489-16-7
naphthalen-1-ylmethyl hydrogen sulfate
ii2k3jd06r ,
unii-ii2k3jd06r
1-naphthalenemethanol, hydrogen sulfate
menaphthyl sulfate
1-naphthalenemethanol, 1-(hydrogen sulfate)
DTXSID80181083
Q27280740
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (66.67)18.2507
2000's3 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.95 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]