yangambin and magnolin

yangambin has been researched along with magnolin* in 1 studies

Other Studies

1 other study(ies) available for yangambin and magnolin

Article	Year
In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii. Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3 The overproduction of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Humans; I-kappa B Proteins; Lignans; Lignin; Magnetic Resonance Spectroscopy; Magnolia; Neurons; NF-KappaB Inhibitor alpha; Nitric Oxide; Plant Extracts; Transcription Factor RelA	2009

Article

Year

In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii.

Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

The overproduction of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB.

Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Humans; I-kappa B Proteins; Lignans; Lignin; Magnetic Resonance Spectroscopy; Magnolia; Neurons; NF-KappaB Inhibitor alpha; Nitric Oxide; Plant Extracts; Transcription Factor RelA

2009