yangambin has been researched along with Edema* in 1 studies
1 other study(ies) available for yangambin and Edema
| Article | Year |
|---|---|
Molecular mechanism underlying anti-inflammatory activities of lirioresinol B dimethyl ether through suppression of NF-κB and MAPK signaling in in vitro and in vivo models.
The aim of the present study is to explore the anti-inflammatory mechanism of lirioresinol B dimethyl ether via inhibition of multiple signaling pathways in both in vitro and in vivo pharmacological models. To determine the anti-inflammatory activity of the lirioresinol B dimethyl ether, RAW 264.7 macrophages challenged with lipopolysaccharide (LPS) were treated with various concentrations of lirioresinol B dimethyl ether (5, 15, 25, and 50 μM). The results indicated that pretreatment with lirioresinol B dimethyl ether significantly suppressed nuclear factor kappa B (NF-κB) activation, nitric oxide (NO) production, the protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Lirioresinol B dimethyl ether inhibited LPS-induced activation of production of pro-inflammatory cytokines as well as prostaglandin E Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Survival; Cytokines; Dinoprostone; Edema; Freund's Adjuvant; Furans; Hyperalgesia; Lipopolysaccharides; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; NF-kappaB-Inducing Kinase; Nitric Oxide; Protein Serine-Threonine Kinases; RAW 264.7 Cells; Signal Transduction | 2019 |