vicenistatin and mycarose

vicenistatin has been researched along with mycarose* in 1 studies

Other Studies

1 other study(ies) available for vicenistatin and mycarose

Article	Year
Isolation and structure elucidation of vicenistatin M, and importance of the vicenisamine aminosugar for exerting cytotoxicity of vicenistatin. The Journal of antibiotics, 2001, Volume: 54, Issue:3 A new analogue of vicenistatin was isolated from the producing strain Streptomyces sp. HC-34. A characteristic of the elucidated structure involved the existence of a neutral sugar mycarose instead of an aminosugar vicenisamine of vicenistatin. The absolute stereochemistry of the new analogue (named as vicenistatin M) was determined by the synthesis of D-mycarose and of vicenistatin M itself. Biological testing of vicenistatin M suggested the importance of vicenisamine for exerting the cytotoxicity of vicenistatin. Topics: Amino Sugars; Aminoglycosides; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Drug Screening Assays, Antitumor; Glycosides; Hexoses; Humans; Lactams; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Streptomyces; Structure-Activity Relationship; Tumor Cells, Cultured	2001

Article

Year

Isolation and structure elucidation of vicenistatin M, and importance of the vicenisamine aminosugar for exerting cytotoxicity of vicenistatin.

The Journal of antibiotics, 2001, Volume: 54, Issue:3

A new analogue of vicenistatin was isolated from the producing strain Streptomyces sp. HC-34. A characteristic of the elucidated structure involved the existence of a neutral sugar mycarose instead of an aminosugar vicenisamine of vicenistatin. The absolute stereochemistry of the new analogue (named as vicenistatin M) was determined by the synthesis of D-mycarose and of vicenistatin M itself. Biological testing of vicenistatin M suggested the importance of vicenisamine for exerting the cytotoxicity of vicenistatin.

Topics: Amino Sugars; Aminoglycosides; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Drug Screening Assays, Antitumor; Glycosides; Hexoses; Humans; Lactams; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Streptomyces; Structure-Activity Relationship; Tumor Cells, Cultured

2001