Page last updated: 2024-12-07

sulfosulfuron

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Sulfosulfuron is a sulfonylurea herbicide used for the selective control of a wide range of weeds in various crops, including cereals, rice, cotton, and soybeans. It is a potent inhibitor of acetolactate synthase (ALS), an enzyme essential for the biosynthesis of branched-chain amino acids in plants. Sulfosulfuron is absorbed by the plant roots and translocated throughout the plant, leading to a disruption of amino acid synthesis and ultimately plant death. The compound is highly effective in controlling a range of grassy and broadleaf weeds, including annual ryegrass, barnyardgrass, pigweed, and lambsquarters. Sulfosulfuron has a long residual activity in the soil, providing extended weed control. The synthesis of Sulfosulfuron involves a multi-step process that includes the coupling of a sulfonamide derivative with a substituted pyrimidine ring. Extensive research has been conducted on Sulfosulfuron, focusing on its efficacy, mode of action, environmental fate, and potential for resistance development in weeds. Sulfosulfuron is widely used in agricultural practices due to its effectiveness in controlling weeds and its relatively low mammalian toxicity. However, concerns have been raised about the potential for environmental contamination and the development of herbicide resistance in weeds. Ongoing research aims to understand the environmental impacts of Sulfosulfuron and develop sustainable weed management strategies. The compound's efficacy and long-lasting effect make it an important tool for weed control, but its environmental fate and potential for resistance require continued monitoring and research.'

Cross-References

ID SourceID
PubMed CID86426
CHEMBL ID2251590
SCHEMBL ID66574
MeSH IDM0404890

Synonyms (37)

Synonym
141776-32-1
AC-18034
sulfosulfuron [iso]
sulfosulfuron
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazo[1,2-a]pyridin-3-yl)sulfonylurea
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-(ethylsulfonyl)h-imidazo[1,2-a]pyridin-3-ylsulfonyl)urea
A23916
hsdb 7942
imidazo(1,2-a)pyridine-3-sulfonamide, n-(((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)-2-(ethylsulfonyl)-
y0xc20dl6d ,
unii-y0xc20dl6d
n-(((4,6-dimethoxy-2-pyrimidinyl)-amino)carbonyl)-2-ethylsulfonylimidazo(1,2-a)pyridine-3-sulfonamide
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazol[1,2-a]pyridin-3-ylsulfonyl)urea
FT-0631163
AKOS015895296
sundance
sulfosulfuron [mi]
maverick
1-(2-ethylsulfonylimidazol(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea
mon-37500
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazo(1,2-a)pyridin-3-ylsulfonyl)urea
n-(((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)-2-(ethylsulfonyl)imidazo(1,2-a)pyridine-3-sulfonamide
SCHEMBL66574
CHEMBL2251590
DTXSID4034940
imidazo[1,2-a]pyridine-3-sulfonamide, n-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-2-(ethylsulfonyl)-
sulfosulfuron, pestanal(r), analytical standard
J-007554
(ethylsulfonyl)imidazo[1,2-a]
n-(4,6-dimethoxypyrimidin-2-ylcarbamoyl)-2-
ulfosulfuron
mfcd04034670
sulfosulfuron 100 microg/ml in acetonitrile
AS-14869
Q2364499
D94518
CS-0113835

Research Excerpts

Overview

Sulfosulfuron is a low-use rate sulfonylurea herbicide.

ExcerptReferenceRelevance
"Sulfosulfuron is a low-use rate sulfonylurea herbicide. "( Mammalian toxicology overview and human risk assessment for sulfosulfuron.
Healy, CE; Heydens, WF; Naylor, MW, 2004
)
2.01

Dosage Studied

ExcerptRelevanceReference
" The aim of this paper is to assess selectivity of various herbicides in grass seed crops by using dose-response curves."( Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
Jensen, JE; Mathiesen, TJ; Ritz, C; Streibig, JC; Tind, T, 2009
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (35)

Assay IDTitleYearJournalArticle
AID1112296Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112277Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112279Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1104245Herbicidal activity against Poa pratensis subsp. pratensis applied using logarithmic sprayer2009Pest management science, Nov, Volume: 65, Issue:11
Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
AID1112299Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112301Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112288Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1104243Toxicity against Festuca rubra applied using logarithmic sprayer2009Pest management science, Nov, Volume: 65, Issue:11
Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
AID1112283Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112293Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112295Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112294Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112282Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112278Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112300Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112304Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112287Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112289Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112285Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112302Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112291Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112286Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112275Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112284Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1104237Ratio of ED50 for Lolium perenne to ED50 for Poa pratensis subsp. Pratensis2009Pest management science, Nov, Volume: 65, Issue:11
Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
AID1112310Herbicidal activity against ALS-inhibiting herbicide-susceptible two-leaf stage Bromus diandrus var. rigidus seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spraying2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112274Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112280Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112292Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112290Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112298Herbicidal activity against ALS-inhibiting herbicide-susceptible two-leaf stage Bromus diandrus var. rigidus seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spraying2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112303Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112276Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112281Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112297Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (51.52)29.6817
2010's11 (33.33)24.3611
2020's5 (15.15)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.78 (24.57)
Research Supply Index3.56 (2.92)
Research Growth Index4.53 (4.65)
Search Engine Demand Index74.55 (26.88)
Search Engine Supply Index3.95 (0.95)

This Compound (30.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.94%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (97.06%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]