Compounds > sulfosulfuron
Page last updated: 2024-12-07

sulfosulfuron

Sulfosulfuron is a sulfonylurea herbicide used for the selective control of a wide range of weeds in various crops, including cereals, rice, cotton, and soybeans. It is a potent inhibitor of acetolactate synthase (ALS), an enzyme essential for the biosynthesis of branched-chain amino acids in plants. Sulfosulfuron is absorbed by the plant roots and translocated throughout the plant, leading to a disruption of amino acid synthesis and ultimately plant death. The compound is highly effective in controlling a range of grassy and broadleaf weeds, including annual ryegrass, barnyardgrass, pigweed, and lambsquarters. Sulfosulfuron has a long residual activity in the soil, providing extended weed control. The synthesis of Sulfosulfuron involves a multi-step process that includes the coupling of a sulfonamide derivative with a substituted pyrimidine ring. Extensive research has been conducted on Sulfosulfuron, focusing on its efficacy, mode of action, environmental fate, and potential for resistance development in weeds. Sulfosulfuron is widely used in agricultural practices due to its effectiveness in controlling weeds and its relatively low mammalian toxicity. However, concerns have been raised about the potential for environmental contamination and the development of herbicide resistance in weeds. Ongoing research aims to understand the environmental impacts of Sulfosulfuron and develop sustainable weed management strategies. The compound's efficacy and long-lasting effect make it an important tool for weed control, but its environmental fate and potential for resistance require continued monitoring and research.'

Cross-References

ID SourceID
PubMed CID86426
CHEMBL ID2251590
SCHEMBL ID66574
MeSH IDM0404890

Synonyms (37)

Synonym
141776-32-1
AC-18034
sulfosulfuron [iso]
sulfosulfuron
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazo[1,2-a]pyridin-3-yl)sulfonylurea
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-(ethylsulfonyl)h-imidazo[1,2-a]pyridin-3-ylsulfonyl)urea
A23916
hsdb 7942
imidazo(1,2-a)pyridine-3-sulfonamide, n-(((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)-2-(ethylsulfonyl)-
y0xc20dl6d ,
unii-y0xc20dl6d
n-(((4,6-dimethoxy-2-pyrimidinyl)-amino)carbonyl)-2-ethylsulfonylimidazo(1,2-a)pyridine-3-sulfonamide
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazol[1,2-a]pyridin-3-ylsulfonyl)urea
FT-0631163
AKOS015895296
sundance
sulfosulfuron [mi]
maverick
1-(2-ethylsulfonylimidazol(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea
mon-37500
1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-ethylsulfonylimidazo(1,2-a)pyridin-3-ylsulfonyl)urea
n-(((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)-2-(ethylsulfonyl)imidazo(1,2-a)pyridine-3-sulfonamide
SCHEMBL66574
CHEMBL2251590
DTXSID4034940
imidazo[1,2-a]pyridine-3-sulfonamide, n-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-2-(ethylsulfonyl)-
sulfosulfuron, pestanal(r), analytical standard
J-007554
(ethylsulfonyl)imidazo[1,2-a]
n-(4,6-dimethoxypyrimidin-2-ylcarbamoyl)-2-
ulfosulfuron
mfcd04034670
sulfosulfuron 100 microg/ml in acetonitrile
AS-14869
Q2364499
D94518
CS-0113835

Research Excerpts

Overview

Sulfosulfuron is a low-use rate sulfonylurea herbicide.

ExcerptReferenceRelevance
"Sulfosulfuron is a low-use rate sulfonylurea herbicide. "( Mammalian toxicology overview and human risk assessment for sulfosulfuron.
Healy, CE; Heydens, WF; Naylor, MW, 2004)		2.01

Dosage Studied

ExcerptRelevanceReference
" The aim of this paper is to assess selectivity of various herbicides in grass seed crops by using dose-response curves."( Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
Jensen, JE; Mathiesen, TJ; Ritz, C; Streibig, JC; Tind, T, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (35)

Assay IDTitleYearJournalArticle
AID1112296Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112277Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112279Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1104245Herbicidal activity against Poa pratensis subsp. pratensis applied using logarithmic sprayer2009Pest management science, Nov, Volume: 65, Issue:11
Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
AID1112299Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112301Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112288Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1104243Toxicity against Festuca rubra applied using logarithmic sprayer2009Pest management science, Nov, Volume: 65, Issue:11
Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
AID1112283Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112293Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112295Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112294Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112282Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112278Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112300Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112304Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112287Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112289Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112285Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112302Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R3 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112291Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112286Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112275Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112284Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1104237Ratio of ED50 for Lolium perenne to ED50 for Poa pratensis subsp. Pratensis2009Pest management science, Nov, Volume: 65, Issue:11
Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
AID1112310Herbicidal activity against ALS-inhibiting herbicide-susceptible two-leaf stage Bromus diandrus var. rigidus seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spraying2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112274Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112280Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112292Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R6 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112290Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 in absence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Bromu2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112298Herbicidal activity against ALS-inhibiting herbicide-susceptible two-leaf stage Bromus diandrus var. rigidus seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spraying2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112303Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R2 seedlings exposed to compound spraying in absence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound sprayi2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112276Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R4 seedlings assessed as reduction in above-ground biomass exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor m2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112281Resistance index, ratio of LD50 for ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R5 in presence of 1000 g/ha cytochrome P450 inhibitor malathion to LD50 for ALS-inhibiting herbicide-susceptible two-leaf stage Brom2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
AID1112297Herbicidal activity against ALS-inhibiting herbicide-resistant two-leaf stage Bromus diandrus var. rigidus biotype R1 seedlings exposed to compound spraying in presence of 1000 g/ha cytochrome P450 inhibitor malathion measured 28 days after compound spray2012Pest management science, Jul, Volume: 68, Issue:7
Non-target-site-based resistance to ALS-inhibiting herbicides in six Bromus rigidus populations from Western Australian cropping fields.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (51.52)29.6817
2010's11 (33.33)24.3611
2020's5 (15.15)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.78 (24.57)
Research Supply Index3.56 (2.92)
Research Growth Index4.53 (4.65)
Search Engine Demand Index74.55 (26.88)
Search Engine Supply Index3.95 (0.95)

This Compound (30.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.94%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (97.06%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0810halide anion;
monoatomic bromine
carbamates
[no description available]		2.0810amino-acid anion
acetochlor
acetochlor : A monocarboxylic acid amide that is N-phenylacetamide carrying an ethyl and a methyl group at positions 2 and 6 respectively on the benzene ring while one of the methyl hydrogens as well as the hydrogen attached to the nitrogen atom have been replaced by a chloro and an ethoxymethyl group respectively.		2.0210aromatic amide;
monocarboxylic acid amide;
organochlorine compound		environmental contaminant;
herbicide;
xenobiotic
cypermethrin
cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.		2.610aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound		agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide
glyphosate
glyphosate: active cpd in herbicidal formulation Roundup; inhibits EC 2.5.1.19, 5-enolpyruvylshikimate-3-phosphate synthase; structure. glyphosate : A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).		2.0510glycine derivative;
phosphonic acid		agrochemical;
EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor;
herbicide
dimethyldodecylbenzylammonium
dimethyldodecylbenzylammonium: RN given refers to parent cpd. benzododecinium : A quaternary ammonium ion obtained by methylation of N-benzyl-N-methyldodecan-1-amine.		2.0210quaternary ammonium ion
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.1110titanium group element atom
pronamide
pronamide: structure. propyzamide : A member of the class of benzamides resulting from the formal condensation of the carboxy group of 3,5-dichlorobenzoic acid with the amino group of 2-methylbut-3-yn-2-amine. It is used as a systemic post-emergent herbicide for the control grass and broadleaf weeds in a wide range of in a wide variety of fruit and root crops.		2.0810benzamides;
dichlorobenzene;
terminal acetylenic compound		agrochemical;
herbicide
isoproturon
isoproturon : A member of the class of phenylureas that is 1,1-dimethylurea substituted by a p-cumenyl group at position 3. A selective, systemic herbicide used to control annual grasses and broadleaf weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.		2.46203-(3,4-substituted-phenyl)-1,1-dimethylureaagrochemical;
environmental contaminant;
herbicide;
xenobiotic
pendimethalin
pendimethalin : A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual grasses and many annual broad-leaved weeds.		2.0510C-nitro compound;
secondary amino compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide
chlorsulfuron
chlorsulfuron: RN given refers to parent cpd; structure given in first source. chlorsulfuron : An N-sulfonylurea that is N-carbamoyl-2-chlorobenzenesulfonamide in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used for the control of broadleaf weeds in wheat, barley and oats.		7.2510methoxy-1,3,5-triazine;
monochlorobenzenes;
N-sulfonylurea		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
metsulfuron methyl
metsulfuron methyl : A N-sulfonylurea in which the sulfonyl group is attached to a 2-(methoxycarbonyl)phenyl group while a (4-methoxy-6-methyl-1,3,5-triazin-2-yl group replaces one of the amino hydrogens of the remaining urea group.		2.51201,3,5-triazines;
benzoate ester;
N-sulfonylurea		environmental contaminant;
herbicide;
xenobiotic
quizalofop-ethyl
quizalofop-ethyl: RN given refers to parent cpd. quizalofop-ethyl : A racemate coprising equimolar amounts of quizalofop-P-ethyl and its enantiomer, (S)-quizalofop-ethyl. A proherbicide for quizalofop.. ethyl 2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoate : An ethyl ester resulting from the formal condensation of the carboxy group of 2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoic acid with ethanol.		2.610aromatic ether;
ethyl ester;
organochlorine compound;
quinoxaline derivative
imazaquin
imazaquin: RN given refer to parent cpd. imazaquin : A racemate comprising equimolar amounts of (R)- and (S)-imazaquin. It is a pre- and post-emergence herbicide used for the control of grasses and broad-leaved weeds.. 2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]quinoline-3-carboxylic acid : A quinolinemonocarboxylic acid that is quinoline-3-carboxylic acid which is substituted by a 4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl group at position 2.		2.0210imidazolone;
monocarboxylic acid;
quinolinemonocarboxylic acid
prosulfocarb
prosulfocarb : A monothiocarbamic ester that is carbamothioic S-acid substituted by two propyl groups at the nitrogen atom and a benzyl group at the the sulfur atom.		2.0510benzenes;
monothiocarbamic ester		environmental contaminant;
herbicide;
xenobiotic
nicosulfuron
nicosulfuron: inhibits ACETOLACTATE SYNTHASE; Accent is DuPont brand name. nicosulfuron : A N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen.		2.110N-sulfonylurea;
pyridines;
pyrimidines		environmental contaminant;
herbicide;
xenobiotic
pretilachlor
[no description available]		2.2510anilide
dpx e9636
DPX E9636: chemical compound used as a pesticide. rimsulfuron : A N-sulfonylurea that is N-carbamoyl-3-(ethylsulfonyl)pyridine-2-sulfonamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen atom.		2.5320aromatic ether;
N-sulfonylurea;
pyridines;
pyrimidines;
sulfone		environmental contaminant;
herbicide;
xenobiotic
clodinafop-propargyl
clodinafop-propargyl: an herbicide. clodinafop-propargyl : A carboxylic ester resulting from the formal condensation of the carboxy group of clodinafop with the hydroxy group of prop-2-yn-1-ol. It is widely used as a herbicide for the control of annual grass weeds in cereal crops.		2.0510aromatic ether;
carboxylic ester;
organochlorine compound;
organofluorine compound;
propyzamide;
pyridines		agrochemical;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
herbicide
flupyrsulfuron
flupyrsulfuron: structure in first source		2.0510
pyrachlostrobin
pyraclostrobin : A carbamate ester that is the methyl ester of [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]methoxycarbamic acid. A fungicide used to control major plant pathogens including Septoria tritici, Puccinia spp. and Pyrenophora teres.		2.0810aromatic ether;
carbamate ester;
carbanilate fungicide;
methoxycarbanilate strobilurin antifungal agent;
monochlorobenzenes;
pyrazoles		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
xenobiotic
iodosulfuron
[no description available]		2.0510
sodium titanate
[no description available]		7.1110
clay
Clay: A naturally-occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter.		2.2510
volunteers
clethodim: structure in first source. clethodim : An oxime O-ether resulting from the formal conversion ot the acyclic keto group of 5-[2-(ethylsulfanyl)propyl]-3-hydroxy-2-propionylcyclohex-2-en-1-one to the corresponding oxime with subsequent O-alkylation of the oxime by an (E)-3-chloroallyl group. It is used as a selective postemergence herbicide for the control of annual and perennial grasses in numerous crops, including alfalfa, celery, clover, conifers, cotton, cranberries, garlic, onions, ornamentals, peanuts, soybeans, strawberries, sugarbeet, sunflowers, and vegetables; the (-)-enantiomer has been reported to be more active than the (+)-enantiomer.		2.610
sethoxydim
sethoxydim: structure given in Merck Index		2.610organic hydroxy compound
imidacloprid
imidacloprid: systemic & contact insecticide exhibiting low mammalian toxicity; structure given in first source; it is one of the neonicotinoid insecticides, which acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system. imidacloprid : An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1.		2.5820imidacloprid;
imidazolidines;
monochloropyridine		environmental contaminant;
genotoxin;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
dinitrobenzenes
Dinitrobenzenes: Benzene derivatives which are substituted with two nitro groups in the ortho, meta or para positions.		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0110
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