Page last updated: 2024-12-06
prosulfocarb
Description
Prosulfocarb is a fungicide that is used to control a wide range of fungal diseases on various crops. It is a broad-spectrum fungicide that inhibits the growth of fungi by interfering with the synthesis of ergosterol, an essential component of fungal cell membranes. Prosulfocarb is synthesized through a multi-step process that involves the reaction of N-methyl-N-phenylthiocarbamoyl chloride with a substituted thiophenol. The mechanism of action of prosulfocarb involves the inhibition of the biosynthesis of ergosterol in fungi. Ergosterol is a sterol that is essential for the structural integrity and function of fungal cell membranes. By inhibiting the synthesis of ergosterol, prosulfocarb disrupts the cell membrane and prevents the fungal cells from growing and dividing. Prosulfocarb is used to control various fungal diseases on a variety of crops, including apples, grapes, potatoes, tomatoes, and rice. It is also used to control fungal diseases in lawns and gardens. The importance of prosulfocarb lies in its effectiveness in controlling a wide range of fungal diseases. It is a highly effective fungicide that provides good control of fungal diseases and has a long residual activity. This makes it a valuable tool for managing fungal diseases in crops, lawns, and gardens. Prosulfocarb is also relatively safe for humans and the environment when used according to label directions. It is a popular choice among farmers and gardeners due to its efficacy and safety. Prosulfocarb has been studied extensively for its effects on fungal pathogens, its efficacy in controlling fungal diseases, and its environmental impact. Studies have shown that prosulfocarb is effective in controlling a wide range of fungal diseases, including powdery mildew, downy mildew, leaf spot, and rust. It has also been found to be relatively safe for humans and the environment when used according to label directions. However, some studies have suggested that prosulfocarb may have some negative environmental impacts, such as the potential for soil and water contamination. Further research is ongoing to assess the long-term environmental impacts of prosulfocarb.'
prosulfocarb : A monothiocarbamic ester that is carbamothioic S-acid substituted by two propyl groups at the nitrogen atom and a benzyl group at the the sulfur atom. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 62020 |
| CHEMBL ID | 2251843 |
| CHEBI ID | 81941 |
| SCHEMBL ID | 20845 |
| MeSH ID | M0275628 |
Synonyms (45)
| Synonym |
|---|
| s-benzyl dipropyl thiolcarbamate |
| boxer (ici agrochemicals) |
| prosulfurocarb herbicide |
| benzyl dipropylthiolcarbamate |
| s-benzyl dipropylthiocarbamate |
| s-benzyl n,n-dipropylthiocarbamate |
| s-benzyl dipropylthiolcarbamate |
| n,n-dipropylthiocarbamate de s-benzyle [french] |
| prosulfocarb [iso] |
| sc 0574 |
| s-(phenylmethyl) dipropylcarbamothioate |
| defi |
| s-benzyl dipropylthiocarbamate (iupac) |
| brn 4804364 |
| r 15574 |
| rcra waste no. u387 |
| prosulfocarb |
| arkade |
| carbamothioic acid, dipropyl-, s-(phenylmethyl) ester |
| s-benzyl-n,n-dipropylthiocarbamat [german] |
| carbamic acid, dipropylthio-, s-benzyl ester |
| s-benzyl n,n-dipropylcarbamothioate |
| 52888-80-9 |
| C18760 |
| AKOS016011247 |
| 8vce6fu50d , |
| unii-8vce6fu50d |
| n,n-dipropylthiocarbamate de s-benzyle |
| ec 401-730-6 |
| s-benzyl-n,n-dipropylthiocarbamat |
| SCHEMBL20845 |
| SS-4633 |
| CHEMBL2251843 |
| chebi:81941 , |
| s-benzyl dipropyl(thiocarbamate) |
| s-(phenylmethyl) n,n-dipropylcarbamothioate |
| s-benzyl dipropylcarbamothioate |
| DTXSID3058119 |
| NQLVQOSNDJXLKG-UHFFFAOYSA-N |
| prosulfocarb, pestanal(r), analytical standard |
| prosulfocarb 10 microg/ml in acetonitrile |
| mfcd00145179 |
| Q22808799 |
| F87965 |
| n,n-dipropyl(benzylsulfanyl)formamide |
Research Excerpts
Overview
Prosulfocarb is a thiocarbamate herbicide. It is rapidly growing in use due to the progressive bioresistance of weeds to certain pesticides.
Bioavailability
| Excerpt | Reference | Relevance |
|---|
| " Further tests showed that the strong affinity of PSC for soil organic matter affected its bioavailability and hence its biodegradation by the inocula." | ( Bioavailability and biodegradation of prosulfocarb in soil.
Ambrosoli, R; Gennari, M; Minati, JL; Nègre, M, 2002) | 0.59 |
| "Adding organic amendments to soil could modify the bioavailability of herbicides and lead to changes in the microbial community's activity and structure." | ( Assessment of
Barba, V; García-Delgado, C; Marín-Benito, JM; Rodríguez-Cruz, MS; Sánchez-Martín, MJ, 2019) | 0.51 |
Dosage Studied
Roles (3)
| Role | Description |
|---|
| environmental contaminant | Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| xenobiotic | A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. |
| herbicide | A substance used to destroy plant pests. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (2)
| Class | Description |
|---|
| benzenes | Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives. |
| monothiocarbamic ester | A thiocarbamic ester formally derived from a monothiocarbamic acid. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (14)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 42.44
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 42.44 (24.57) | | Research Supply Index | 2.71 (2.92) | | Research Growth Index | 5.10 (4.65) | | Search Engine Demand Index | 85.90 (26.88) | | Search Engine Supply Index | 2.94 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |