Compounds > prosulfocarb
Page last updated: 2024-12-06

prosulfocarb

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Prosulfocarb is a fungicide that is used to control a wide range of fungal diseases on various crops. It is a broad-spectrum fungicide that inhibits the growth of fungi by interfering with the synthesis of ergosterol, an essential component of fungal cell membranes. Prosulfocarb is synthesized through a multi-step process that involves the reaction of N-methyl-N-phenylthiocarbamoyl chloride with a substituted thiophenol. The mechanism of action of prosulfocarb involves the inhibition of the biosynthesis of ergosterol in fungi. Ergosterol is a sterol that is essential for the structural integrity and function of fungal cell membranes. By inhibiting the synthesis of ergosterol, prosulfocarb disrupts the cell membrane and prevents the fungal cells from growing and dividing. Prosulfocarb is used to control various fungal diseases on a variety of crops, including apples, grapes, potatoes, tomatoes, and rice. It is also used to control fungal diseases in lawns and gardens. The importance of prosulfocarb lies in its effectiveness in controlling a wide range of fungal diseases. It is a highly effective fungicide that provides good control of fungal diseases and has a long residual activity. This makes it a valuable tool for managing fungal diseases in crops, lawns, and gardens. Prosulfocarb is also relatively safe for humans and the environment when used according to label directions. It is a popular choice among farmers and gardeners due to its efficacy and safety. Prosulfocarb has been studied extensively for its effects on fungal pathogens, its efficacy in controlling fungal diseases, and its environmental impact. Studies have shown that prosulfocarb is effective in controlling a wide range of fungal diseases, including powdery mildew, downy mildew, leaf spot, and rust. It has also been found to be relatively safe for humans and the environment when used according to label directions. However, some studies have suggested that prosulfocarb may have some negative environmental impacts, such as the potential for soil and water contamination. Further research is ongoing to assess the long-term environmental impacts of prosulfocarb.'

prosulfocarb : A monothiocarbamic ester that is carbamothioic S-acid substituted by two propyl groups at the nitrogen atom and a benzyl group at the the sulfur atom. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID62020
CHEMBL ID2251843
CHEBI ID81941
SCHEMBL ID20845
MeSH IDM0275628

Synonyms (45)

Synonym
s-benzyl dipropyl thiolcarbamate
boxer (ici agrochemicals)
prosulfurocarb herbicide
benzyl dipropylthiolcarbamate
s-benzyl dipropylthiocarbamate
s-benzyl n,n-dipropylthiocarbamate
s-benzyl dipropylthiolcarbamate
n,n-dipropylthiocarbamate de s-benzyle [french]
prosulfocarb [iso]
sc 0574
s-(phenylmethyl) dipropylcarbamothioate
defi
s-benzyl dipropylthiocarbamate (iupac)
brn 4804364
r 15574
rcra waste no. u387
prosulfocarb
arkade
carbamothioic acid, dipropyl-, s-(phenylmethyl) ester
s-benzyl-n,n-dipropylthiocarbamat [german]
carbamic acid, dipropylthio-, s-benzyl ester
s-benzyl n,n-dipropylcarbamothioate
52888-80-9
C18760
AKOS016011247
8vce6fu50d ,
unii-8vce6fu50d
n,n-dipropylthiocarbamate de s-benzyle
ec 401-730-6
s-benzyl-n,n-dipropylthiocarbamat
SCHEMBL20845
SS-4633
CHEMBL2251843
chebi:81941 ,
s-benzyl dipropyl(thiocarbamate)
s-(phenylmethyl) n,n-dipropylcarbamothioate
s-benzyl dipropylcarbamothioate
DTXSID3058119
NQLVQOSNDJXLKG-UHFFFAOYSA-N
prosulfocarb, pestanal(r), analytical standard
prosulfocarb 10 microg/ml in acetonitrile
mfcd00145179
Q22808799
F87965
n,n-dipropyl(benzylsulfanyl)formamide

Research Excerpts

Overview

Prosulfocarb is a thiocarbamate herbicide. It is rapidly growing in use due to the progressive bioresistance of weeds to certain pesticides.

ExcerptReferenceRelevance
"Prosulfocarb is a thiocarbamate herbicide that is rapidly growing in use due to the progressive bioresistance of weeds to certain pesticides and the ban and/or limitation of others. "( Prosulfocarb at center stage!
Devault, DA; Eymery, F; Guillemin, JP; Hulin, M; Merlo, M; Millet, M, 2022)		3.61

Bioavailability

ExcerptReferenceRelevance
" Further tests showed that the strong affinity of PSC for soil organic matter affected its bioavailability and hence its biodegradation by the inocula."( Bioavailability and biodegradation of prosulfocarb in soil.
Ambrosoli, R; Gennari, M; Minati, JL; Nègre, M, 2002)		0.59
"Adding organic amendments to soil could modify the bioavailability of herbicides and lead to changes in the microbial community's activity and structure."( Assessment of
Barba, V; García-Delgado, C; Marín-Benito, JM; Rodríguez-Cruz, MS; Sánchez-Martín, MJ, 2019)		0.51

Dosage Studied

ExcerptRelevanceReference
" The aim of this paper is to assess selectivity of various herbicides in grass seed crops by using dose-response curves."( Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
Jensen, JE; Mathiesen, TJ; Ritz, C; Streibig, JC; Tind, T, 2009)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
environmental contaminantAny minor or unwanted substance introduced into the environment that can have undesired effects.
xenobioticA xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
herbicideA substance used to destroy plant pests.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
monothiocarbamic esterA thiocarbamic ester formally derived from a monothiocarbamic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1104245Herbicidal activity against Poa pratensis subsp. pratensis applied using logarithmic sprayer2009Pest management science, Nov, Volume: 65, Issue:11
Using a selectivity index to evaluate logarithmic spraying in grass seed crops.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's4 (28.57)29.6817
2010's7 (50.00)24.3611
2020's2 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 42.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index42.44 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index85.90 (26.88)
Search Engine Supply Index2.94 (0.95)

This Compound (42.44)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		4.03130amino-acid anion
glyphosate
glyphosate: active cpd in herbicidal formulation Roundup; inhibits EC 2.5.1.19, 5-enolpyruvylshikimate-3-phosphate synthase; structure. glyphosate : A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).		2.0510glycine derivative;
phosphonic acid		agrochemical;
EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor;
herbicide
metolachlor
metolachlor: structure given in first source. metolachlor : A racemate that consists of equimolar amounts of (R)- and (S)-metolachlor.. 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl)acetamide : An organochlorine compound that is 2-chloroacetamide substituted by a (2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl) group at the nitrogen atom.		7.1310aromatic amide;
benzenes;
ether;
organochlorine compound
triallate
Triallate: A pre-emergence, selective herbicide for the control of wild oats in various crops.		7.0810tertiary amine
trifluralin
Trifluralin: A microtubule-disrupting pre-emergence herbicide.. trifluralin : A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.		2.6120(trifluoromethyl)benzenes;
C-nitro compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		2.8130isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
phenmedipham
phenmedipham: minor descriptor (72-84); on-line search CARBAMATES (72-84); Index Medicus search HERBICIDES, CARBAMATE (75-84), CARBAMATES (72-75). phenmedipham : A carbamate ester that is (3-methylphenyl)carbamic acid in which the hydrogen of the hydroxy group has been replaced by a 3-[(methoxycarbonyl)amino]phenyl group.		2.0310carbamate esterenvironmental contaminant;
herbicide;
xenobiotic
pendimethalin
pendimethalin : A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual grasses and many annual broad-leaved weeds.		2.0510C-nitro compound;
secondary amino compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide
triasulfuron
triasulfuron : An N-sulfonylurea that is N-[o-(2-chloroethoxy)phenyl]sulfonylurea in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used to control broad-leaved weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life.		7.17101,3,5-triazines;
aromatic ether;
N-sulfonylurea;
organochlorine compound		agrochemical;
herbicide
sulfosulfuron
[no description available]		2.0510
clodinafop-propargyl
clodinafop-propargyl: an herbicide. clodinafop-propargyl : A carboxylic ester resulting from the formal condensation of the carboxy group of clodinafop with the hydroxy group of prop-2-yn-1-ol. It is widely used as a herbicide for the control of annual grass weeds in cereal crops.		2.0510aromatic ether;
carboxylic ester;
organochlorine compound;
organofluorine compound;
propyzamide;
pyridines		agrochemical;
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor;
herbicide
flupyrsulfuron
flupyrsulfuron: structure in first source		2.0510
iodosulfuron
[no description available]		2.0510
pyroxasulfone
pyroxasulfone: an herbicide		2.8130
ConditionIndicatedRelationship StrengthStudiesTrials