pimprinine profile

Pimprinine is a natural product isolated from the medicinal plant *Piper longum* (long pepper). It exhibits a range of biological activities, including anti-inflammatory, analgesic, and antioxidant properties. Research on pimprinine is motivated by its potential therapeutic applications in treating inflammatory conditions and pain. Studies have shown that pimprinine can inhibit the production of pro-inflammatory cytokines and mediators, suggesting its potential as an anti-inflammatory agent. Its antioxidant properties have also been linked to its ability to scavenge free radicals, which can contribute to oxidative stress and damage. Further research is ongoing to fully understand the mechanism of action of pimprinine and explore its potential as a therapeutic agent.'

pimprinine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	96578
SCHEMBL ID	12364396
MeSH ID	M0053175

Synonym
nsc-80793
nsc80793
pimprinine
pimprinine (hindustan antibiotic)
13640-26-1
5-(1h-indol-3-yl)-2-methyl-1,3-oxazole
1h-indole, 3-(2-methyl-5-oxazolyl)-
AKOS006287160
crw4nit4w1 ,
nsc 80793
5,3'-indolyl-2-methyloxazole
unii-crw4nit4w1
CCG-40387
5-(1h-indol-3-yl)-2-methyl-oxazole
SCHEMBL12364396
HB4028
DTXSID80159782
J-006842
3-(2-methyl-5-oxazolyl)-1h-indole
3-(2-methyl-1,3-oxazol-5-yl)-1h-indole
NCGC00507755-01
antibiotic ws 30581c
5-(3-indolyl)-2-methyloxazole
5-(1h-indol-3-yl)-2-methyloxazole
Z1198175856
HY-120769
CS-0079119

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (18.18)	29.6817
2010's	5 (45.45)	24.3611
2020's	4 (36.36)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	2.07	1	indole; polycyclic heteroarene	Escherichia coli metabolite
phenytoin [no description available]	2	1	imidazolidine-2,4-dione	anticonvulsant; drug allergen; sodium channel blocker; teratogenic agent
tremorine [no description available]	2	1	N-alkylpyrrolidine
cytidine [no description available]	2.21	1	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	3.9	11	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	7.11	1	metal allergen; nickel group element atom; platinum group metal atom
ribavirin Rebetron: Rebetron is tradename	2.21	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
1,3,4-oxadiazole 1,3,4-oxadiazole: structure in first source	7.31	1
deoxycholic acid Deoxycholic Acid: A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.. deoxycholic acid : A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.	2.01	1	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human blood serum metabolite
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	2.55	2
ningnanmycin ningnanmycin: isolated from Strepcomces noursei	2.21	1
streptochlorin streptochlorin: inhibits both NF-kappaB activation and angiogenesis; isolated from marine Streptomyces; structure in first source	2.31	1

Condition	Relationship Strength	Studies
Cancer of Lung [description not available]	2.01	1
Cancer of Pancreas [description not available]	2.01	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.01	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.01	1
Acute Hypercapnic Respiratory Failure [description not available]	2	1
Absence Seizure [description not available]	2	1
Action Tremor [description not available]	2	1
Respiratory Insufficiency Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)	2	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	2	1
Tremor Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.	2	1

pimprinine

Description

Cross-References

Synonyms (27)

Research Excerpts

Research

Studies (11)

Market Indicators

Research Demand Index: 21.82

Study Types