scutebarbatine A: has antineoplastic activity; isolated from Scutellaria barbata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Scutellaria | genus | A plant genus of the family Lamiaceae used in folk medicine.[MeSH] | Lamiaceae | The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 45110781 |
| CHEMBL ID | 3577094 |
| MeSH ID | M000602778 |
| Synonym |
|---|
| scutebarbatine a |
| 176520-13-1 |
| CHEMBL3577094 |
| AKOS037515187 |
| [(1r,2s,3r,4r,4as,8ar)-3-hydroxy-3,4,8,8a-tetramethyl-4-[(e)-2-(5-oxo-2h-furan-3-yl)ethenyl]-2-(pyridine-3-carbonyloxy)-2,4a,5,6-tetrahydro-1h-naphthalen-1-yl] pyridine-3-carboxylate |
| (-)-scutebarbatine a |
| CS-0016664 |
| HY-N1260 |
| FS-10489 |
Scutebarbatine A is a new neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata. It has many pharmacological effects, such as anti-tumor, antibacterial, and anti-inflammatory.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Scutebarbatine A is a new neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata, which has many pharmacological effects, such as anti-tumor, antibacterial, and anti-inflammatory. " | ( Identification of the Metabolites of Scutebarbatine A in Rat Plasma, Bile, Urine, and feces by Using Ultra-high-performance Liquid Chromatography Coupled with Q Exactive Hybrid Quadrupole-orbitrap High-resolution Mass Spectrometry. Gao, J; Sun, L; Wang, H; Yang, G; Yuan, N; Zhao, L, 2022) | 2.44 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1318675 | Cytotoxicity against human MCF7 cells assessed as inhibition of cell survival rate at 50 uM after 48 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Oct-04, Volume: 121 | neo-Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells. |
| AID1225463 | Antiviral activity against EBV infected in TPA and sodium butyrate-induced P3HR1 cells assessed as inhibition on EBV lytic replication at 20 uM incubated for 48 hrs by SYBR green dye based real-time PCR method | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (18.04) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||