Page last updated: 2024-12-10
sc-46275
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5311427 |
| CHEMBL ID | 49922 |
| MeSH ID | M0195537 |
Synonyms (25)
| Synonym |
|---|
| 137255-19-7 |
| fz6t2mqr9r , |
| unii-fz6t2mqr9r |
| methyl 7-(2beta-(6-(1-cyclo-pentyl-yl)-4r-hydroxy-4-methyl-1e,5e-hexadienyl)-3alpha-hydroxy-5-oxo-1r,1alpha-cyclopentyl)-4z-heptenoate |
| 4-heptenoic acid, 7-(2-(6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadienyl)-3-hydroxy-5-oxocyclopentyl)-, methyl ester, (1r-(1alpha(z),2beta(1e,4r*,5e),3alpha))- |
| sc46275 |
| sc-46275 , |
| CHEMBL49922 |
| methyl (z)-7-[(1r,2r,3r)-2-[(1e,4r,5e)-6-(cyclopenten-1-yl)-4-hydroxy-4-methylhexa-1,5-dienyl]-3-hydroxy-5-oxocyclopentyl]hept-4-enoate |
| gtpl3331 |
| methyl (4z)-7-[(1r,2r,3r)-2-[(1e,4r,5e)-6-(cyclopent-1-en-1-yl)-4-hydroxy-4-methylhexa-1,5-dien-1-yl]-3-hydroxy-5-oxocyclopentyl]hept-4-enoate |
| remiprostol, (1r,2r,3r,4'r)- |
| 4-heptenoic acid, 7-(2-(6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadienyl)-3-hydroxy-5-oxocyclopentyl)-, methyl ester, (1r-(1.alpha.(z),2.beta.(1e,4r*,5e),3.alpha.))- |
| 4-heptenoic acid, 7-((1r,2r,3r)-2-((1e,4r,5e)-6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadien-1-yl)-3-hydroxy-5-oxocyclopentyl)-, methyl ester, (4z)- |
| sc 46275 |
| 4-heptenoic acid, 7-(2-(6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadienyl)-3-hydroxy-5-oxocyclopentyl)-, methyl ester, (1.alpha.(z),2.beta.(1e,4r*,5e),3.alpha.)-(+/-)- |
| 4-heptenoic acid, 7-((1r,2r,3r)-2-((1e,4r,5e)-6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadien-1-yl)-3-hydroxy-5-oxocyclopentyl)-, methyl ester, (4z)-rel- |
| unii-nyg10z50bh |
| nyg10z50bh , |
| remiprostol, (1s,2s,3s,4's)-(+/-)- |
| 110902-56-2 |
| 4-heptenoic acid, 7-(2-(6-(1-cyclopenten-1-yl)-4-hydroxy-4-methyl-1,5-hexadienyl)-3-hydroxy-5-oxocyclopentyl)-, methyl ester, (1alpha(z),2beta(1e,4r*,5e),3alpha)-(+/-)- |
| remiprostol, (1r,2r,3r,4'r)-(+/-)- |
| Q27088746 |
| AKOS040753962 |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| " bioavailability in unoperated fasted dogs." | ( SC-46275: a potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog. Bauer, RF; Burton, EG; Casler, JJ; Collins, PW; Gaginella, TS; Gasiecki, AF; Jones, PH; Perkins, WE; Tsai, BS, 1991) | 1.72 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID59834 | Gastric antisecretory activity in food stimulated pavlov dogs by intrapouch administration | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of acyclic omega chain conjugated diene analogues of enisoprost. |
| AID229654 | Selectivity ratio was evaluated by the quotient of diarrheal ED50 value divided by antisecretory ED50 x 10 E-3 | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of acyclic omega chain conjugated diene analogues of enisoprost. |
| AID177069 | Compound was evaluated for diarrheagenic side effects in adult male rats by intragastric administration | 1992 | Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4 | Synthesis and structure-activity relationships of acyclic omega chain conjugated diene analogues of enisoprost. |
| AID60034 | Tested for gastric antisecretory activity in dogs by intrapouch administration | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogues of enisoprost. Identification of a promising new antiulcer prostaglandin. |
| AID176830 | Tested for diarrheal side effects in rats by intragastric administration | 1990 | Journal of medicinal chemistry, Oct, Volume: 33, Issue:10 | Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogues of enisoprost. Identification of a promising new antiulcer prostaglandin. |
| AID1346396 | Rat EP3 receptor (Prostanoid receptors) | 2006 | Prostaglandins, leukotrienes, and essential fatty acids, Jun, Volume: 74, Issue:6 | Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.95
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.95) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||