17,20-dimethylisocarbacyclin profile

## 17,20-Dimethylisocarbacyclin: A Prostaglandin Analogue with Potential

17,20-dimethylisocarbacyclin (also known as **DMCI**) is a synthetic **prostaglandin analogue** with a unique structure and pharmacological properties. It is structurally similar to **carbacyclin**, a potent and selective agonist of the **prostacyclin receptor (IP receptor)**.

**Why is it important for research?**

DMCI holds potential for research in several areas:

* **Cardiovascular Research:**
* **Vasodilation:** Like carbacyclin, DMCI acts as a potent vasodilator, relaxing smooth muscle in blood vessels. This property could be relevant for treating conditions like **hypertension** or **pulmonary hypertension**.
* **Anti-platelet activity:** DMCI inhibits platelet aggregation, preventing blood clots. This could be valuable for preventing **thrombosis** and **atherosclerosis**.
* **Neurological Research:**
* **Neuroprotection:** Studies have shown that DMCI can protect neurons from damage caused by various insults, including **ischemia** and **oxidative stress**. This opens up possibilities for treating **neurodegenerative diseases** like Alzheimer's and Parkinson's disease.
* **Anti-inflammatory Research:**
* **Anti-inflammatory effects:** DMCI has shown anti-inflammatory properties in various models of inflammation. This could be useful for treating inflammatory conditions like **arthritis**.
* **Cancer Research:**
* **Anticancer activity:** Some research suggests that DMCI might possess anticancer properties, inhibiting the growth of certain types of cancer cells.

**However, DMCI research is still in its early stages. More research is needed to fully understand its efficacy, safety, and potential therapeutic applications.**

**Key Points to Remember:**

* 17,20-dimethylisocarbacyclin (DMCI) is a synthetic prostaglandin analogue with a unique structure.
* It is a potent agonist of the prostacyclin receptor (IP receptor).
* DMCI shows promise in various research areas, including cardiovascular, neurological, anti-inflammatory, and cancer research.
* Further research is crucial to explore DMCI's therapeutic potential and assess its safety profile.

**Important Note:** The information provided here is for general knowledge and should not be taken as medical advice. Consult with a qualified healthcare professional for any health concerns.

17,20-dimethylisocarbacyclin: improves hypothermic preservation of rat liver [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6449856
MeSH ID	M0160482

Synonym
17,20-dimethylisocarbacyclin
2-pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(3-hydroxy-1-nonenyl)-, (3ar-(3aalpha,5beta,6alpha(1e,3r*),6aalpha))-
122168-74-5
5-[(3ar,5s,6s,6ar)-5-hydroxy-6-[(e,3r)-3-hydroxynon-1-enyl]-1,3a,4,5,6,6a-hexahydropentalen-2-yl]pentanoic acid

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	3 (60.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	1.99	1	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	1.99	1	benzenes; phenyl acetates
octimibate [no description available]	1.99	1
bmy 45778 BMY 45778: structure given in first source; partial prostacyclin agonist	1.99	1	bisoxazole	partial prostacyclin agonist
bmy 42393 BMY 42393: partial prostacyclin agonist	1.99	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
alprostadil [no description available]	2	1	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent
clinprost TEI 9090: structure given in first source	1.97	1
17-phenyltrinorprostaglandin e2 17-phenyltrinorprostaglandin E2: an EP1 receptor agonist. 17-phenyl-18,19,20-trinor-prostaglandin E2 : A prostanoid that is 18,19,20-trinor-prostaglandin E2 in which one of the terminal methyl hydrogens has been replaced by a phenyl group.	2	1	alicyclic ketone; beta-hydroxy ketone; hydroxy monocarboxylic acid; olefinic compound; oxo monocarboxylic acid; prostanoid; secondary alcohol	human metabolite; prostaglandin receptor agonist
ah 23848 AH 23848: thromboxane antagonist. AH23848 : A racemate comprising equimolar amounts of (1R,2R,5S)- and (1S,2S,5R)-enantiomers of (4Z)-7-{5-[([1,1'-biphenyl]-4-yl)methoxy]-2-(morpholin-4-yl)-3-oxocyclopentyl}hept-4-enoic acid. The hemicalcium salt is a potent, specific thromboxane receptor-blocking drug that is orally active and has a long duration of action.. (1R,2R,5S)-AH23848 : A (4Z)-7-{5-[([1,1'-biphenyl]-4-yl)methoxy]-2-(morpholin-4-yl)-3-oxocyclopentyl}hept-4-enoic acid in which the stereocentres at positions 1, 2 and 5 have R-, R- and S-configuration respectively.	2	1	(4Z)-7-{5-[([1,1'-biphenyl]-4-yl)methoxy]-2-(morpholin-4-yl)-3-oxocyclopentyl}hept-4-enoic acid
cicaprost cicaprost: RN given refers to (3aS-(2E,3aalpha,4alpha(3R,4R),5beta,6aalpha))-isomer	2.4	2	monoterpenoid
iloprost Iloprost: An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.. iloprost : A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.	2.39	2	carbobicyclic compound; monocarboxylic acid; secondary alcohol	platelet aggregation inhibitor; vasodilator agent
taprostene [no description available]	2.4	2	benzoic acids
sc-46275 [no description available]	2	1
sulprostone sulprostone: structure	2	1	prostanoid
9-o-methanoprostaglandin i 9-O-methanoprostaglandin I: shows weak inhibitory activity in rabbit platelet aggregation induced by ADP; RN given refers to cpd without isomeric designation	1.97	1
tei 3356 TEI 3356: a prostaglandin E receptor agonist; inhibits endothelin-induced DNA synthesis in cultured vascular smooth muscle cells; structure given in first source	1.97	1
cardiovascular agents Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.	1.99	1
guanosine triphosphate Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.	1.97	1	guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor

17,20-dimethylisocarbacyclin

Description

Cross-References

Synonyms (4)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.80

Study Types