| AID1624130 | Effect on total AKT expression in LPS-stimulated mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1299226 | Inhibition of TNFalpha-activated nuclear factor-kappa B activity (unknown origin) expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene based assay | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. |
| AID1624126 | Effect on IKK-mediated IkappaBalpha degradation in LPS-stimulated mouse RAW264.7 cells assessed as IkappaBalpha recovery at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured after 20 to 240 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1377198 | Cytotoxicity against human ACHN cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay | 2017 | Journal of natural products, 07-28, Volume: 80, Issue:7
| Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. |
| AID1442763 | Cytotoxicity in human ACHN cells assessed as reduce cell number after 48 hrs by MTS assay | 2017 | Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
| 17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships. |
| AID480902 | Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5
| Antiproliferative activity of withanolides against human breast cancer cell lines. |
| AID480905 | Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5
| Antiproliferative activity of withanolides against human breast cancer cell lines. |
| AID480903 | Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5
| Antiproliferative activity of withanolides against human breast cancer cell lines. |
| AID1624115 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS challenge and measured after 18 hrs by Griess assay | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1624111 | Effect on ERK1/2 phosphorylation at T202/Y204 residues in mouse RAW264.7 cells at 5 uM measured after 30 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1624129 | Inhibition of LPS-induced AKT phosphorylation at S473 residue in mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1377196 | Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay | 2017 | Journal of natural products, 07-28, Volume: 80, Issue:7
| Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. |
| AID1442751 | Sensitization of TRAIL-induced apoptosis in human ACHN cells assessed as reduction in cell viability preincubated for 2 hrs followed by addition of TRAIL measured after 18 hrs by MTS assay | 2017 | Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
| 17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships. |
| AID1377199 | Cytotoxicity against human M14 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay | 2017 | Journal of natural products, 07-28, Volume: 80, Issue:7
| Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. |
| AID1624125 | Effect on IKK-mediated IkappaBalpha degradation in LPS-stimulated mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured after 10 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1299228 | Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells at 50 uM pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. |
| AID1624118 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS mRNA expression preincubated for 30 mins followed by LPS challenge and measured after 3 to 12 hrs by SYBR green dye based qRT-PCR analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1624121 | Effect on SAPK/JNK1/2 phosphorylation at T183/Y185 residues in mouse RAW264.7 cells at 5 uM measured after 30 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1442764 | Glutathione reactivity in DMSO assessed as formation of MIchael adduct with GSH at pH 7.4 after 24 hrs in presence of NAC by HPLC method | 2017 | Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
| 17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships. |
| AID1624120 | Effect on p38 phosphorylation at T180/Y182 residues in mouse RAW264.7 cells at 5 uM measured after 30 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID480904 | Antiproliferative activity against human MCF7/BUS cells expressing estrogen receptor after 48 hrs by SRB assay | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5
| Antiproliferative activity of withanolides against human breast cancer cell lines. |
| AID1377201 | Cytotoxicity against HFF cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay | 2017 | Journal of natural products, 07-28, Volume: 80, Issue:7
| Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. |
| AID1299230 | Toxicity against mouse RAW264.7 cells assessed as cell survival at 50 uM by SRB assay | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. |
| AID1624133 | Inhibition of LPS-induced STAT1 phosphorylation at Y701 residue in mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID397122 | Inhibition of HIV1 RT | | | |
| AID1624134 | Effect on total STAT1 expression in LPS-stimulated mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1299225 | Inhibition of TNFalpha-activated nuclear factor-kappa B activity (unknown origin) expressed in HEK293 cells at 50 uM incubated for 6 hrs by luciferase reporter gene based assay | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. |
| AID1377197 | Cytotoxicity against human 22Rv1 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay | 2017 | Journal of natural products, 07-28, Volume: 80, Issue:7
| Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. |
| AID1624112 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS expression at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1624119 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 mRNA expression preincubated for 30 mins followed by LPS challenge and measured after 3 to 12 hrs by SYBR green dye based qRT-PCR analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1299227 | Toxicity against HEK293 cells assessed as cell survival at 50 uM | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. |
| AID1624113 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite levels at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Griess assay (Rvb = 3 | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1624116 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS expression preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1624114 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 expression at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1377200 | Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay | 2017 | Journal of natural products, 07-28, Volume: 80, Issue:7
| Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. |
| AID480906 | Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5
| Antiproliferative activity of withanolides against human breast cancer cell lines. |
| AID1624117 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 expression preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3
| Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. |
| AID1299229 | Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay | 2016 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
| Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |