Page last updated: 2024-12-06

4beta-Hydroxywithanolide E

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID73621
CHEMBL ID502563
CHEBI ID176191

Synonyms (23)

Synonym
(1s,2r,6s,7r,9r,11r,12r,15s,16s)-15-[(1s)-1-[(2r)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]-1-hydroxyethyl]-6,12,15-trihydroxy-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one
CHEBI:176191
4-beta-hydroxywithanolide e
NSC212509 ,
4.beta.-hydroxywithanolide e
54334-04-2
ergosta-2, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, .delta.-lactone
ergosta-2, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, .delta.-lactone, (4.beta.,5.beta.,6.beta.,17.alpha.,22r)-
withanolide e, 4-b-hydroxy-
nsc-212509
NCI60_001790
ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, delta-lactone, (4-beta,5-beta,6-beta,17-alpha,22r)-
withanolide e, 4-beta-hydroxy-
4beta-hydroxywithanolide e
5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxoergosta-2,24-dien-26-oic acid delta-lactone
nsc 212509
CHEMBL502563 ,
4beta-hydroxywithanolide
bdbm50480318
5beta,6beta-epoxy-4beta,14,17alpha,20,22r-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, -lactone
DTXSID701314108
PD124678
AKOS040761159
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
withanolideAny steroid lactone that is a C28 steroid with a modified side chain forming a lactone ring and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (38)

Assay IDTitleYearJournalArticle
AID1624130Effect on total AKT expression in LPS-stimulated mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1299226Inhibition of TNFalpha-activated nuclear factor-kappa B activity (unknown origin) expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene based assay2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.
AID1624126Effect on IKK-mediated IkappaBalpha degradation in LPS-stimulated mouse RAW264.7 cells assessed as IkappaBalpha recovery at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured after 20 to 240 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1377198Cytotoxicity against human ACHN cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.
AID1442763Cytotoxicity in human ACHN cells assessed as reduce cell number after 48 hrs by MTS assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships.
AID480902Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID480905Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID480903Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID1624115Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS challenge and measured after 18 hrs by Griess assay2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1624111Effect on ERK1/2 phosphorylation at T202/Y204 residues in mouse RAW264.7 cells at 5 uM measured after 30 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1624129Inhibition of LPS-induced AKT phosphorylation at S473 residue in mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1377196Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.
AID1442751Sensitization of TRAIL-induced apoptosis in human ACHN cells assessed as reduction in cell viability preincubated for 2 hrs followed by addition of TRAIL measured after 18 hrs by MTS assay2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships.
AID1377199Cytotoxicity against human M14 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.
AID1624125Effect on IKK-mediated IkappaBalpha degradation in LPS-stimulated mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured after 10 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1299228Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells at 50 uM pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.
AID1624118Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS mRNA expression preincubated for 30 mins followed by LPS challenge and measured after 3 to 12 hrs by SYBR green dye based qRT-PCR analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1624121Effect on SAPK/JNK1/2 phosphorylation at T183/Y185 residues in mouse RAW264.7 cells at 5 uM measured after 30 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1442764Glutathione reactivity in DMSO assessed as formation of MIchael adduct with GSH at pH 7.4 after 24 hrs in presence of NAC by HPLC method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships.
AID1624120Effect on p38 phosphorylation at T180/Y182 residues in mouse RAW264.7 cells at 5 uM measured after 30 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID480904Antiproliferative activity against human MCF7/BUS cells expressing estrogen receptor after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID1377201Cytotoxicity against HFF cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.
AID1299230Toxicity against mouse RAW264.7 cells assessed as cell survival at 50 uM by SRB assay2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.
AID1624133Inhibition of LPS-induced STAT1 phosphorylation at Y701 residue in mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID397122Inhibition of HIV1 RT
AID1624134Effect on total STAT1 expression in LPS-stimulated mouse RAW264.7 cells at 5 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1299225Inhibition of TNFalpha-activated nuclear factor-kappa B activity (unknown origin) expressed in HEK293 cells at 50 uM incubated for 6 hrs by luciferase reporter gene based assay2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.
AID1377197Cytotoxicity against human 22Rv1 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.
AID1624112Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS expression at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1624119Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 mRNA expression preincubated for 30 mins followed by LPS challenge and measured after 3 to 12 hrs by SYBR green dye based qRT-PCR analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1299227Toxicity against HEK293 cells assessed as cell survival at 50 uM2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.
AID1624113Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite levels at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Griess assay (Rvb = 32019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1624116Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS expression preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1624114Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 expression at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1377200Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by CellTiter96 AQueous one solution cell proliferation assay2017Journal of natural products, 07-28, Volume: 80, Issue:7
Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.
AID480906Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay2010Journal of natural products, May-28, Volume: 73, Issue:5
Antiproliferative activity of withanolides against human breast cancer cell lines.
AID1624117Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 expression preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis2019Journal of natural products, 03-22, Volume: 82, Issue:3
Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1.
AID1299229Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 30 mins before LPS stimulation for 20 hrs by Griess reagent based assay2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]