| ID Source | ID |
|---|---|
| PubMed CID | 44577222 |
| CHEMBL ID | 468568 |
| CHEBI ID | 68967 |
| SCHEMBL ID | 15345361 |
| Synonym |
|---|
| vanilloloside |
| CHEMBL468568 |
| chebi:68967 , |
| SIMPNXWTAVEOTO-RKQHYHRCSA-N |
| 4-(beta-d-glucopyranosyloxy)-3-methoxybenzyl alcohol |
| SCHEMBL15345361 |
| beta-d-glucopyranoside, 4-(hydroxymethyl)-2-methoxyphenyl |
| vanillyl alcohol 4-o-beta-d-glucopyranoside |
| 4-(hydroxymethyl)-2-methoxyphenyl beta-d-glucopyranoside |
| unii-uu9vco3b28 |
| 74950-96-2 |
| (2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-(4-(hydroxymethyl)-2-methoxy-phenoxy)tetrahydropyran-3,4,5-triol |
| UU9VCO3B28 , |
| vanillyl alcohol 4-o-.beta.-d-glucopyranoside |
| .beta.-d-glucopyranoside, 4-(hydroxymethyl)-2-methoxyphenyl |
| 4-(hydroxymethyl)-2-methoxyphenyl .beta.-d-glucopyranoside |
| glucovanillyl alcohol |
| NCGC00385285-01 |
| ncgc00385285-01_c14h20o8_beta-d-glucopyranoside, 4-(hydroxymethyl)-2-methoxyphenyl |
| Q27137319 |
| DTXSID401317658 |
| (2r,3s,4s,5r,6s)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)-2-methoxyphenoxy]oxane-3,4,5-triol |
| compound np-002611 |
| AKOS040739948 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| glycoside | A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID356382 | Immunoregulatory activity assessed as inhibition of T cell proliferation at 0.1 uM | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Copacamphane, picrotoxane, and alloaromadendrane sesquiterpene glycosides and phenolic glycosides from Dendrobium moniliforme. |
| AID356381 | Immunoregulatory activity assessed as stimulation of B cell proliferation at 10 uM | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Copacamphane, picrotoxane, and alloaromadendrane sesquiterpene glycosides and phenolic glycosides from Dendrobium moniliforme. |
| AID356383 | Cytotoxicity against T cell | 2003 | Journal of natural products, Aug, Volume: 66, Issue:8 | Copacamphane, picrotoxane, and alloaromadendrane sesquiterpene glycosides and phenolic glycosides from Dendrobium moniliforme. |
| AID632953 | Cytotoxicity against human CCD-18Co cells after 72 hrs by MTS assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Phenolic glycosides from sugar maple (Acer saccharum) bark. |
| AID632952 | Cytotoxicity against human Caco2 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Phenolic glycosides from sugar maple (Acer saccharum) bark. |
| AID632951 | Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, Nov-28, Volume: 74, Issue:11 | Phenolic glycosides from sugar maple (Acer saccharum) bark. |
| AID385238 | Inhibition of COX2 at 10 uM | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | Itosides J-N from Itoa orientalis and structure - anti-COX-2 activity relationship of phenolic glycosides. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.79) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||