Geranylgeranyl transferase type-2 subunit alpha

A geranylgeranyl transferase type-2 subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92696]

Synonyms

EC 2.5.1.60;
Geranylgeranyl transferase type II subunit alpha;
Rab geranyl-geranyltransferase subunit alpha;
Rab GG transferase alpha;
Rab GGTase alpha;
Rab geranylgeranyltransferase subunit alpha

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ne 10790	Homo sapiens (human)	Activity	200.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
Rab geranylgeranyltransferase activity	molecular function	Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. [EC:2.5.1.60, GOC:mah, PMID:8621375]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
Rab-protein geranylgeranyltransferase complex	cellular component	An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein). [GOC:jl, PMID:11886217]

Involved In

This protein is involved in 3 target(s):

Target	Category	Definition
visual perception	biological process	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai]
protein geranylgeranylation	biological process	The covalent attachment of a geranylgeranyl group to a protein. [GOC:jl]
protein modification process	biological process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]

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