ne-10790 and Multiple-Myeloma

ne-10790 has been researched along with Multiple-Myeloma* in 1 studies

Other Studies

1 other study(ies) available for ne-10790 and Multiple-Myeloma

Article	Year
N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. Bioorganic & medicinal chemistry letters, 2015, Jun-01, Volume: 25, Issue:11 The N-oxide derivatives of [2-(3-pyridinyl)-1-hydroxyethylidene-1,1-phosphonocarboxylic acid (or PEHPC) and [2-(3-pyridinyl)-1-ethylidene-1,1-phosphonocarboxylic acid (or PEPC) have been prepared and evaluated for their activity against several enzymes which utilize isoprenoids. The parent pyridines are known inhibitors of GGTase II, but the N-oxide derivatives show no improvement in biological activity in assays with the isolated enzyme. However, the PEHPC N-oxide did induce significant accumulation of intracellular light chain in myeloma cells, consistent with inhibition of Rab geranylgeranylation. Topics: Alkyl and Aryl Transferases; Cell Line, Tumor; Drug Discovery; Humans; Molecular Structure; Multiple Myeloma; Propionates; Structure-Activity Relationship	2015

Article

Year

N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation.

Bioorganic & medicinal chemistry letters, 2015, Jun-01, Volume: 25, Issue:11

The N-oxide derivatives of [2-(3-pyridinyl)-1-hydroxyethylidene-1,1-phosphonocarboxylic acid (or PEHPC) and [2-(3-pyridinyl)-1-ethylidene-1,1-phosphonocarboxylic acid (or PEPC) have been prepared and evaluated for their activity against several enzymes which utilize isoprenoids. The parent pyridines are known inhibitors of GGTase II, but the N-oxide derivatives show no improvement in biological activity in assays with the isolated enzyme. However, the PEHPC N-oxide did induce significant accumulation of intracellular light chain in myeloma cells, consistent with inhibition of Rab geranylgeranylation.

Topics: Alkyl and Aryl Transferases; Cell Line, Tumor; Drug Discovery; Humans; Molecular Structure; Multiple Myeloma; Propionates; Structure-Activity Relationship

2015