murrayanine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

murrayanine: carbazole alkaloid from Murraya koenigii; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Murraya	genus	A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.[MeSH]	Rutaceae	A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID Source	ID
PubMed CID	96942
CHEMBL ID	1689802
CHEBI ID	69934
SCHEMBL ID	3087481
MeSH ID	M0453203

Synonyms (24)

Synonym
1-methoxy-9h-carbazole-3-carbaldehyde
ACON1_002117
nsc-94931
nsc94931
MEGXP0_001488
C09228 ,
723-97-7
murrayanine
9h-carbazole-3-carboxaldehyde, 1-methoxy-
BRD-K47742288-001-01-8
chebi:69934 ,
CHEMBL1689802
unii-3nin8ia768
1-methoxy-9h-carbazole-3-carboxaldehyde
3nin8ia768 ,
nsc 94931
SCHEMBL3087481
DTXSID80222627
1-methoxy-9h-carbazole-3-carboxaldehyde, 9ci
3-formyl-1-methoxycarbazole
FWNZQNAJETXQPP-UHFFFAOYSA-N
carbazole-3-carboxaldehyde, 1-methoxy-
Q27104978
AKOS040763142

Research Excerpts

Treatment

Excerpt	Reference	Relevance
"Murrayanine treatment increased apoptosis of the A549 cells and increased cleaved of caspase-3 and caspase-9, and the Bax/Bcl-2 ratio."	( Murrayanine Induces Cell Cycle Arrest, Oxidative Stress, and Inhibition of Phosphorylated p38 Expression in A549 Lung Adenocarcinoma Cells. Gao, Y; Ma, C; Wang, Y; Zhang, J, 2019)	2.68

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

Class	Description
carbazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID664750	Neuroprotective activity in rat PC12 cells assessed as inhibition of SNP-induced cell death at 10 uM incubated 24 hrs post SNP-challenge for 24 hrs by MTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Carbazole alkaloids from the stems of Clausena lansium.
AID1151356	Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins	2014	Journal of natural products, May-23, Volume: 77, Issue:5	Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity.
AID1151355	Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry	2014	Journal of natural products, May-23, Volume: 77, Issue:5	Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity.
AID664751	Neuroprotective activity in rat PC12 cells assessed as inhibition of serum starvation-induced cell death after 24 hrs by MTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Carbazole alkaloids from the stems of Clausena lansium.
AID587892	Cytotoxicity against human KB cells by resazurin microplate assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.
AID587894	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.
AID587893	Cytotoxicity against human NCI-H187 by resazurin microplate assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.
AID664749	Neuroprotective activity in rat PC12 cells assessed as inhibition of amyloid beta(25 to 35)-induced cell death at 10 uM incubated 48 hrs post amyloid beta-challenge for 24 hrs by MTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Carbazole alkaloids from the stems of Clausena lansium.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (25.00)	29.6817
2010's	6 (75.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.25 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.92 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.25)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coumarin 2H-chromen-2-one: coumarin derivative	2.1	1	coumarins	fluorescent dye; human metabolite; plant metabolite
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	2.06	1	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source	2.1	1	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector
carbazole carbazole: structure in first source	2.45	2	carbazole
imperatorin imperatorin: tumor necrosis factor antagonist; furanocoumarin from West African medicinal plant Clausena anisata; structure in Negwer, 5th ed, #3005. imperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.	2.1	1	psoralens	EC 3.1.1.7 (acetylcholinesterase) inhibitor; metabolite
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.1	1	D-glucopyranose	epitope; mouse metabolite
xanthyletine xanthyletine: structure	2.1	1	coumarins
xanthoxyletin xanthoxyletin: structure in first source	2.06	1	coumarins	metabolite
isoimperatorin isoimperatorin: tumor necrosis factor antagonist isolated from Glehniae root. isoimperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.	2.1	1	psoralens	EC 3.1.1.7 (acetylcholinesterase) inhibitor; metabolite
girinimbine girinimbine: carbazole alkaloid	2.06	1	carbazoles	metabolite
7-methoxyheptaphylline 7-methoxyheptaphylline: cytotoxic carbazole alkaloid from the roots of Clausena harmandiana; structure in first source	2.06	1	carbazoles	metabolite
dentatin dentatin: from Clausena excavata; structure in first source	2.06	1	coumarins	metabolite
murrayafoline a murrayafoline A: structure in first source	2.02	1
methyl carbazole-3-carboxylate methyl carbazole-3-carboxylate: structure in first source	2.1	1	carbazoles
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.1	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite
clausine e clausine E: structure in first source	2.06	1	carbazoles	metabolite
8-geranyloxypsoralen [no description available]	2.1	1	terpene lactone
heptaphylline heptaphylline: cytotoxic carbazole alkaloid from the roots of Clausena harmandiana; structure in first source	2.06	1	carbazoles	metabolite
osthenol osthenol: structure in first source. osthenol : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group.	2.1	1	hydroxycoumarin	antifungal agent; plant metabolite
adicardin adicardin: isolated from the roots and stems of Gmelina arborea; structure in first source	2.1	1
mahanine mahanine: structure in first source	2.02	1
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.1	1	benzenes; hydroxycoumarin; methyl ketone
claulansine f claulansine F: a free radical scavenger isolated from the stem of Clausena lansium; structure in first source	2.07	1

Condition	Relationship Strength	Studies
Blood Poisoning [description not available]	2.21	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.47	2
Innate Inflammatory Response [description not available]	2.21	1
MODS [description not available]	2.21	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	7.21	1
Multiple Organ Failure A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.	2.21	1
Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	7.21	1
Lung Adenocarcinoma [description not available]	7.21	1
Adenocarcinoma, Basal Cell [description not available]	2.21	1
Cancer of Lung [description not available]	2.21	1
Adenocarcinoma of Lung A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.	2.21	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	7.21	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.21	1

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