murrayanine: carbazole alkaloid from Murraya koenigii; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Murraya | genus | A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.[MeSH] | Rutaceae | A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 96942 |
| CHEMBL ID | 1689802 |
| CHEBI ID | 69934 |
| SCHEMBL ID | 3087481 |
| MeSH ID | M0453203 |
| Synonym |
|---|
| 1-methoxy-9h-carbazole-3-carbaldehyde |
| ACON1_002117 |
| nsc-94931 |
| nsc94931 |
| MEGXP0_001488 |
| C09228 , |
| 723-97-7 |
| murrayanine |
| 9h-carbazole-3-carboxaldehyde, 1-methoxy- |
| BRD-K47742288-001-01-8 |
| chebi:69934 , |
| CHEMBL1689802 |
| unii-3nin8ia768 |
| 1-methoxy-9h-carbazole-3-carboxaldehyde |
| 3nin8ia768 , |
| nsc 94931 |
| SCHEMBL3087481 |
| DTXSID80222627 |
| 1-methoxy-9h-carbazole-3-carboxaldehyde, 9ci |
| 3-formyl-1-methoxycarbazole |
| FWNZQNAJETXQPP-UHFFFAOYSA-N |
| carbazole-3-carboxaldehyde, 1-methoxy- |
| Q27104978 |
| AKOS040763142 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Murrayanine treatment increased apoptosis of the A549 cells and increased cleaved of caspase-3 and caspase-9, and the Bax/Bcl-2 ratio." | ( Murrayanine Induces Cell Cycle Arrest, Oxidative Stress, and Inhibition of Phosphorylated p38 Expression in A549 Lung Adenocarcinoma Cells. Gao, Y; Ma, C; Wang, Y; Zhang, J, 2019) | 2.68 |
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| carbazoles | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID664750 | Neuroprotective activity in rat PC12 cells assessed as inhibition of SNP-induced cell death at 10 uM incubated 24 hrs post SNP-challenge for 24 hrs by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Carbazole alkaloids from the stems of Clausena lansium. |
| AID1151356 | Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity. |
| AID1151355 | Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry | 2014 | Journal of natural products, May-23, Volume: 77, Issue:5 | Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity. |
| AID664751 | Neuroprotective activity in rat PC12 cells assessed as inhibition of serum starvation-induced cell death after 24 hrs by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Carbazole alkaloids from the stems of Clausena lansium. |
| AID587892 | Cytotoxicity against human KB cells by resazurin microplate assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana. |
| AID587894 | Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana. |
| AID587893 | Cytotoxicity against human NCI-H187 by resazurin microplate assay | 2011 | Journal of natural products, Feb-25, Volume: 74, Issue:2 | Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana. |
| AID664749 | Neuroprotective activity in rat PC12 cells assessed as inhibition of amyloid beta(25 to 35)-induced cell death at 10 uM incubated 48 hrs post amyloid beta-challenge for 24 hrs by MTT assay | 2012 | Journal of natural products, Apr-27, Volume: 75, Issue:4 | Carbazole alkaloids from the stems of Clausena lansium. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.25) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||