Page last updated: 2024-12-06

mergocriptine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Mergocriptine is an ergot alkaloid with a complex chemical structure. It is synthesized from the fungus Claviceps purpurea, which grows on rye and other grains. Mergocriptine is known for its dopamine agonist properties, meaning it binds to and activates dopamine receptors in the brain. This action leads to various pharmacological effects, including the inhibition of prolactin secretion, reduction of pituitary tumors, and treatment of Parkinson's disease. Its importance lies in its therapeutic potential for conditions related to dopamine dysfunction. Researchers study mergocriptine to understand its mechanisms of action, explore its potential as a drug for various neurological disorders, and investigate its safety and efficacy. The complex structure and diverse effects of mergocriptine make it an interesting subject of scientific investigation.'

mergocriptine: structure given in first source; RN given refers to (5'alpha)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID54803
CHEMBL ID2105887
SCHEMBL ID2109602
MeSH IDM0184695

Synonyms (19)

Synonym
mergocriptine
81968-16-3
mergocriptina [spanish]
mergocriptine [inn]
2-methyl-alpha-ergocryptine
mergocriptinum [latin]
mergocriptinum
mergocriptina
unii-vxd47yrh4q
vxd47yrh4q ,
2-methyl-.alpha.-ergocryptine
cbm36-733
cbm 36-733
CHEMBL2105887
SCHEMBL2109602
(6ar,9r)-n-[(1s,2s,4r,7s)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-5,7-dimethyl-6,6a,8,9-tetrahydro-4h-indolo[4,3-fg]quinoline-9-carboxamide
Q27292072
DTXSID501002339
n-[10b-hydroxy-5-(2-methylpropyl)-3,6-dioxo-2-(propan-2-yl)octahydro-8h-[1,3]oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-2,6-dimethyl-9,10-didehydroergoline-8-carboximidic acid

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]