Page last updated: 2024-12-11
l 760735
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
L 760735: an NK1 receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 9809076 |
| SCHEMBL ID | 7505308 |
| SCHEMBL ID | 23711371 |
| MeSH ID | M0294678 |
Synonyms (23)
| Synonym |
|---|
| 188923-01-5 |
| 2-(r)-(1-(r)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)4-(5-(dimethyl-amino)methyl-1,2,3-triazol-4-yl)methyl-3-(s)-(4-fluorophenyl)morpholine hcl |
| 2-(r)-(1-(r)-(3,5-bis(trifluoromethyl)-phenyl)ethoxy)4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(s)-(4-fluorophenyl)morpholine hcl salt |
| 2-(r)-(1-(r)-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(s)-(4-fluoro-phenyl)morpholine hydrochloride |
| 2-(r)-(1-(r)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(s)-(4-fluorophenyl)morpholine hydrochloride |
| SCHEMBL7505308 |
| l 760735 |
| 5-[[(2r,3s)-2-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-n,n-dimethyl-1h-1,2,3-triazole-4-methanamine hydrochloride |
| DTXSID30430977 |
| AKOS024457928 |
| l-760735 |
| J-012179 |
| 1-(4-(((2r,3s)-2-((r)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1h-1,2,3-triazol-5-yl)-n,n-dimethylmethanamine hydrochloride |
| 1h-1,2,3-triazole-4-methanamine, 5-(((2r,3s)-2-((1r)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-n,n-dimethyl-, monohydrochloride |
| E4C3XGZ4U7 , |
| 5-((2-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-n,n-dimethyl-1h-1,2,3-triazole-4-methanamine hydrochloride, 2r-(2ar*,3a) |
| l-760735f hydrochloride |
| unii-e4c3xgz4u7 |
| 1-[5-[[(2r,3s)-2-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-2h-triazol-4-yl]-n,n-dimethylmethanamine;hydrochloride |
| SCHEMBL23711371 |
| CS-0028948 |
| HY-108481 |
| AKOS040745222 |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " Electrophysiological recordings were made from brain slices prepared from guinea-pigs that had been dosed orally every day for 4 weeks with either L-760735 (3 mg/kg), imipramine (10 mg/kg), or vehicle (water), or naive animals." | ( Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus. Chicchi, G; Cumberbatch, MJ; Harrison, T; Martin, K; Maubach, KA; Rupniak, NM; Seabrook, GR; Swain, CJ; Wheeldon, A, 2002) | 0.31 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (15)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.69
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.69) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (6.67%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (93.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||