Compounds > hexanoyl-coenzyme a
Page last updated: 2024-11-08

hexanoyl-coenzyme a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID449118
CHEBI ID27540
SCHEMBL ID60392
MeSH IDM0129224

Synonyms (28)

Synonym
coenzyme a, hexanoyl-
s-hexanoyl-coa
n-hexanoyl-coenzyme a
hexanoyl-coenzyme a
s-hexanoyl-coenzyme-a
3'-phosphoadenosine 5'-(3-{(3r)-3-hydroxy-4-[(3-{[2-(hexanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl} dihydrogen diphosphate)
caproyl-coa
5060-32-2
caproyl-coenzyme a
s-hexanoyl-coenzym-a
coenzyme a, s-hexanoate
n-hexanoyl-coa
CHEBI:27540
C05270
hexanoyl-coa ,
DB02563
s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] hexanethioate
SCHEMBL60392
caproyl coenzyme a
hexanoyl coenzyme a
hexanoyl coa
LMFA07050328
s-{(9r,13r,15s)-17-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl} hexanethioate (non-preferred name
Q27103184
9-{5-o-[{[{4-[(3-{[2-(hexanoylsulfanyl)ethyl]imino}-3-hydroxypropyl)imino]-3,4-dihydroxy-2,2-dimethylbutoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-3-o-phosphonopentofuranosyl}-9h-purin-6-amine
DTXSID40964834
s-(2-(3-((2r)-4-(((((((2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) hexanethioate
hexanoyl-coenzyme a; (acyl-coa); [m+h]+;
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
medium-chain fatty acyl-CoAA fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any medium-chain fatty acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (20)

PathwayProteinsCompounds
Fatty Acid Metabolism1441
Fatty Acid Elongation in Mitochondria734
Ethylmalonic Encephalopathy1441
Glutaric Aciduria Type I1441
Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency)1441
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids818
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids823
Carnitine Palmitoyl Transferase Deficiency I1441
Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD)1441
Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD)1441
Carnitine Palmitoyl Transferase Deficiency II1441
Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD)1441
Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD)734
Trifunctional Protein Deficiency1441
Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD)818
Fatty Acid Elongation In Mitochondria334
Fatty Acid Oxidation (Hexanoate)214
Fatty Acid Oxidation (Octanoate)214
Mitochondrial beta-oxidation064
Fatty acid beta-oxidation025
Metabolism overview078

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (6.67)18.7374
1990's1 (6.67)18.2507
2000's5 (33.33)29.6817
2010's8 (53.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.34 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index5.11 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
galactose
galactopyranose : The pyranose form of galactose.		2.2110D-galactose;
galactopyranose		Escherichia coli metabolite;
mouse metabolite
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		2.0110amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		2.4420arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
3-mercaptopropionic acid
3-Mercaptopropionic Acid: An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.. 3-mercaptopropanoic acid : A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.		2.0110mercaptopropanoic acidalgal metabolite
n-pentanoic acid
n-pentanoic acid: RN given refers to unlabeled parent cpd. valeric acid : A straight-chain saturated fatty acid containing five carbon atoms.		1.9610short-chain fatty acid;
straight-chain saturated fatty acid		plant metabolite
hexanoic acid
hexanoic acid : A C6, straight-chain saturated fatty acid.		2.0710medium-chain fatty acid;
straight-chain saturated fatty acid		human metabolite;
plant metabolite
dronabinol
Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.. Delta(9)-tetrahydrocannabinol : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.		2.2110benzochromene;
diterpenoid;
phytocannabinoid;
polyketide		cannabinoid receptor agonist;
epitope;
hallucinogen;
metabolite;
non-narcotic analgesic
acetoacetyl coa
[no description available]		2103-oxo-fatty acyl-CoAEscherichia coli metabolite;
mouse metabolite
delta(9)-tetrahydrocannabinolic acid
Delta(9)-tetrahydrocannabinolic acid : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.		2.2110benzochromene;
diterpenoid;
hydroxy monocarboxylic acid;
phytocannabinoid;
polyketide		anti-inflammatory agent;
biomarker;
metabolite;
neuroprotective agent
butyryl-coenzyme a
[no description available]		2.4920butanoyl-CoAsEscherichia coli metabolite;
mouse metabolite
octanoyl-coenzyme a
[no description available]		2.0510
cannabidiolic acid
cannabidiolic acid: structure. cannabidiolic acid : A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a 3-p-mentha-1,8-dien-3-yl (limonene) group.		2.2110dihydroxybenzoic acid;
phytocannabinoid;
polyketide;
resorcinols
isovaleryl-coenzyme a
[no description available]		2.1110methylbutanoyl-CoA;
short-chain fatty acyl-CoA		mouse metabolite
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		2.21103,5-dihydroxy-3-methylpentanoic acid
geranyl pyrophosphate
geranyl pyrophosphate: RN given refers to (E)-isomer. geranyl diphosphate : The diphosphate of the polyprenol compound geraniol.		2.2110polyprenyl diphosphateEscherichia coli metabolite;
mouse metabolite
palmitoyl coenzyme a
Palmitoyl Coenzyme A: A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.. palmitoyl-CoA : A long-chain fatty acyl-CoA resulting from the formal condensation of the carboxy group of hexadecanoic acid with the thiol group of coenzyme A.		1.961011,12-saturated fatty acyl-CoA;
3-substituted propionyl-CoA;
long-chain fatty acyl-CoA;
palmitoyl bioconjugate		Escherichia coli metabolite;
mouse metabolite
olivetolic acid
olivetolic acid: structure in first source. olivetolic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogens ortho- and para- to the carboxy group are replaced by a pentyl and a hydroxy group, respectively.		2.2110benzoic acids;
monocarboxylic acid;
polyketide;
resorcinols		metabolite
isobutyryl-coenzyme a
[no description available]		2.1110methyl-branched fatty acyl-CoA;
short-chain fatty acyl-CoA		human metabolite;
mouse metabolite
glutaryl-coenzyme a
[no description available]		210glutaryl-CoAsmouse metabolite
crotonyl-coenzyme a
crotonoyl-CoA : The (E)-isomer of but-2-enoyl-CoA.		210but-2-enoyl-CoA
cannabigerolic acid
cannabigerolic acid: structure in first source. cannabigerolic acid : A dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a geranyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.		2.2110dihydroxybenzoic acid;
diterpenoid;
phytocannabinoid;
polyketide;
resorcinols
valeryl-coenzyme a
pentanoyl-CoA : A short-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of pentanoic acid.		2.4120short-chain fatty acyl-CoA
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.0810organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		2.2110monohydroxybenzoateplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Listeria
[description not available]		02.1310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9810