gt-2016 has been researched along with Vestibular-Diseases* in 1 studies
1 other study(ies) available for gt-2016 and Vestibular-Diseases
| Article | Year |
|---|---|
Pharmacological evaluation of an in vivo model of vestibular dysfunction in the rat.
A unilateral microinjection of either histamine or kainic acid was made into the medial vestibular nucleus of rats, eliciting robust barrel rotations that were evaluated by an elevated body-rotation test. Systemic pretreatment with betahistine or GT-2016 significantly attenuated the kainic acid-induced barrel rotations. These data indicate that the animal model described herein may represent a new model to identify novel drugs with potential antivertigo properties. Topics: Animals; Betahistine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Kainic Acid; Male; Microinjections; Rats; Rats, Long-Evans; Vestibular Diseases; Vestibular Nuclei | 1999 |