| Assay ID | Title | Year | Journal | Article |
|---|
| AID1137982 | Inhibition of mouse NAMPT after 30 mins by mass spectrometry-based analysis | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765301 | Tmax in NCR nude mouse at 10 mg/kg, po | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1137999 | Antiproliferative activity against mouse KPR cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1190263 | Time-dependent inhibition of CYP3A4 (unknown origin) using midazolam as substrate assessed as AUC shift | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3
| Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. |
| AID1137984 | Cellular uptake in mouse KPP cells at 1000 nM | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1327684 | Reversible inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH by LC-MS/MS analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID765295 | Antitumor activity against human U251 cells xenografted in athymic nu/nu mouse assessed as reduction in tumor size at 25 mg/kg, po QD for 7 days measured on day 13 | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1137974 | Drug uptake in Sprague-Dawley rat retina at 30 mg/kg, po qd for 2 days measured 1 hr after last dose in presence of nicotinic acid | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765313 | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins LC-MS analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1137995 | Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1190265 | Kinetic solubility of the compound in aqueous buffer at pH 7.4 after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3
| Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. |
| AID1137994 | Antiproliferative activity against human PC3 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1327639 | Reversible inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID1190266 | Thermodynamic solubility of the compound in aqueous buffer at pH 7.4 after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3
| Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. |
| AID1137997 | Antiproliferative activity against human Calu6 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765312 | Intrinsic clearance in CD-1 mouse hepatocytes at 1 uM after 10 mins by LC-MS/MS analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765300 | Clearance in NCR nude mouse plasma at 5 mg/kg, iv | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1137960 | Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based analysis | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765303 | Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1327640 | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate in presence of NADPH by LC-MS/MS analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID1138000 | Antiproliferative activity against mouse B16F10 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1327643 | Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate in presence of NADPH by LC-MS/MS analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID1137996 | Antiproliferative activity against human HCT116 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137979 | Ratio of drug level in retina to plasma of Sprague-Dawley rat at 30 mg/kg, po qd for 2 days measured 6.5 hrs after last dose in presence of nicotinic acid | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765296 | Toxicity in human U251 cells xenografted in athymic nu/nu mouse assessed as change in body weight at 25 mg/kg, po QD for 7 days | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765305 | Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 72 hrs | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1327644 | Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate in presence of NADPH by LC-MS/MS analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID1137975 | Drug uptake in Sprague-Dawley rat retina at 30 mg/kg, po qd for 2 days measured 6.5 hrs after last dose in presence of nicotinic acid | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137983 | Inhibition of rat NAMPT after 30 mins by mass spectrometry-based analysis | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137990 | Cytotoxicity against rhesus monkey RF/6A cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137992 | Inhibition of C-terminal His-6-tagged cynomolgus monkey NAMPT expressed in Escherichia coli (DE3)-RIL cells after 30 mins by mass spectrometry-based analysis | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1138007 | Dissociation constant, pKa of the compound | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1327642 | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH by LC-MS/MS analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID1137963 | Fraction unbound in mouse plasma at 5 uM by LC-MS/MS analysis | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1138008 | Octanol-PBS buffer distribution coefficient, log D of the compound at pH 7.4 by shake flask method | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137991 | Inhibition of C-terminal His-6-tagged dog NAMPT expressed in Escherichia coli (DE3)-RIL cells after 30 mins by mass spectrometry-based analysis | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765299 | Volume of distribution at steady state in NCR nude mouse at 5 mg/kg, iv | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1327638 | Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assay | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID765315 | Antiproliferative activity against human A2780 cells assessed as growth inhibition after 72 hrs by SRB-based microplate reader analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1327641 | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH by LC-MS/MS analysis | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID1138001 | Antiproliferative activity against dog A72 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765307 | Antiproliferative activity against human U251 cells assessed as cell viability after 72 hrs by SRB assay | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1138004 | Cytotoxicity against African green monkey COS1 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137998 | Antiproliferative activity against mouse KPP cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1138003 | Antiproliferative activity against dog DH82 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765302 | Cmax in NCR nude mouse at 10 mg/kg, po | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765298 | Oral bioavailability in NCR nude mouse at 10 mg/kg | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1137987 | Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometry | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137988 | Cellular uptake in human PC3 cells at 200 nM | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765308 | Fraction unbound in mouse plasma at 5 uM after 4 hrs by LC-MS/MS analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765316 | Inhibition of C-terminal His-tagged NAMPT (unknown origin) expressed in Escherichia coli BL21 using nicotinamide as substrate preincubated for 15 mins before substrate addition measured after 30 mins by mass spectrometry-based assay | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765304 | Antiproliferative activity against human PC3 cells assessed as cell viability after 72 hrs | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765297 | AUC (infinity) in NCR nude mouse at 10 mg/kg, po | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765310 | Apparent permeability across apical to basolateral side in dog MDCK cells at 10 uM by LC-MS/MS analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1137978 | Ratio of drug level in retina to plasma of Sprague-Dawley rat at 30 mg/kg, po qd for 2 days measured 1 hr after last dose in presence of nicotinic acid | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1190264 | Time-dependent inhibition of CYP3A4 (unknown origin) using testosterone as substrate assessed as AUC shift | 2015 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 25, Issue:3
| Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. |
| AID765311 | Intrinsic clearance in human hepatocytes at 1 uM after 10 mins by LC-MS/MS analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1137993 | Antiproliferative activity against human HT1080 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1138002 | Antiproliferative activity against dog D17 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137989 | Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometry | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1327637 | Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins in presence of PRPP | 2016 | Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
| Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. |
| AID1137986 | Cellular uptake in human PC3 cells at 1000 nM | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765309 | Fraction unbound in human plasma at 5 uM after 4 hrs by LC-MS/MS analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1138005 | Cytotoxicity against African green monkey COS7 cells assessed as cell viability after 96 hrs by CyQuant staining-based assay | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID1137985 | Cellular uptake in mouse KPP cells at 200 nM | 2013 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20
| Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). |
| AID765314 | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins LC-MS analysis | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID765306 | Antiproliferative activity against human HT1080 cells assessed as cell viability after 72 hrs | 2013 | Journal of medicinal chemistry, Aug-22, Volume: 56, Issue:16
| Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID977608 | Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB | 2014 | PloS one, , Volume: 9, Issue:10
| Structural basis for resistance to diverse classes of NAMPT inhibitors. |
| AID1800299 | NAMPT enzyme assay from Article 10.1002/cbic.201402023: \\Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.\\ | 2014 | Chembiochem : a European journal of chemical biology, May-26, Volume: 15, Issue:8
| Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |