glutamate thiol: structure given in first source; RN given refers to (S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 125415 |
| CHEMBL ID | 27656 |
| SCHEMBL ID | 288415 |
| MeSH ID | M0184660 |
| Synonym |
|---|
| (r)-4-amino-5-mercapto-pentanoic acid |
| bdbm50036817 |
| glutamate thiol |
| CHEMBL27656 , |
| (4r)-4-amino-5-sulfanylpentanoic acid |
| pentanoic acid, 4-amino-5-mercapto-, (s)- |
| (s)-4-amino-5-mercaptopentanoic acid |
| 130306-98-8 |
| SCHEMBL288415 |
| DTXSID70156447 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aminopeptidase N | Homo sapiens (human) | Ki | 17.0000 | 0.0008 | 1.9569 | 10.0000 | AID38376 |
| Glutamyl aminopeptidase | Homo sapiens (human) | Ki | 2.3000 | 2.3000 | 5.1500 | 8.0000 | AID35699 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| virus receptor activity | Aminopeptidase N | Homo sapiens (human) |
| aminopeptidase activity | Aminopeptidase N | Homo sapiens (human) |
| metallopeptidase activity | Aminopeptidase N | Homo sapiens (human) |
| signaling receptor activity | Aminopeptidase N | Homo sapiens (human) |
| metalloaminopeptidase activity | Aminopeptidase N | Homo sapiens (human) |
| zinc ion binding | Aminopeptidase N | Homo sapiens (human) |
| peptide binding | Aminopeptidase N | Homo sapiens (human) |
| aminopeptidase activity | Glutamyl aminopeptidase | Homo sapiens (human) |
| metalloaminopeptidase activity | Glutamyl aminopeptidase | Homo sapiens (human) |
| peptide binding | Glutamyl aminopeptidase | Homo sapiens (human) |
| zinc ion binding | Glutamyl aminopeptidase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID35699 | Inhibition of aminopeptidase A (APA) | 1994 | Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9 | Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors. |
| AID212738 | Inhibitory activity against Tetanus neurotoxin (TeNt) light chain by using fluorescent synaptobrevin derivative [Pya88]S 39-88 as substrate at 10e-3 M. | 1998 | Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18 | Beta-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain. |
| AID38376 | Inhibition of aminopeptidase N (APN) | 1994 | Journal of medicinal chemistry, Apr-29, Volume: 37, Issue:9 | Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.15) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||