Compounds > fr 900482
Page last updated: 2024-09-03

fr 900482 and mitomycin

fr 900482 has been researched along with mitomycin in 7 studies

Compound Research Comparison

Studies
(fr 900482)		Trials
(fr 900482)		Recent Studies (post-2010)
(fr 900482)		Studies
(mitomycin)		Trials
(mitomycin)		Recent Studies (post-2010) (mitomycin)
290412,8931,7382,808

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's4 (57.14)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hirai, O; Kikuchi, H; Matsumoto, S; Mizota, T; Mori, J; Shimomura, K1
Rajski, SR; Rollins, SB; Williams, RM1
Beckerbauer, L; Cullison, J; Reeves, R; Tepe, JJ; Williams, RM1
Colandrea, VJ; Jimenez, LS; Rajaraman, S1
Chamberland, S; Gubler, DA; Namiki, H; Williams, RM1
Chamberland, S; Grüschow, S; Sherman, DH; Williams, RM1
Bass, PD; Gubler, DA; Judd, TC; Williams, RM1

Reviews

1 review(s) available for fr 900482 and mitomycin

ArticleYear
Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches.
    Chemical reviews, 2013, Aug-14, Volume: 113, Issue:8

    Topics: Chemistry Techniques, Synthetic; Drug Resistance, Bacterial; Mitomycin; Mitomycins; Oxazines; Streptomyces

2013

Other Studies

6 other study(ies) available for fr 900482 and mitomycin

ArticleYear
A new antitumor antibiotic, FR-900482. IV. Hematological toxicity in mice.
    The Journal of antibiotics, 1987, Volume: 40, Issue:5

    Topics: Animals; Antibiotics, Antineoplastic; Blood Cell Count; Bone Marrow Cells; Bridged Bicyclo Compounds; Colony-Forming Units Assay; Female; Hematopoiesis; Hematopoietic Stem Cells; Mice; Mitomycin; Mitomycins; Oxazines; Platelet Count; Spleen

1987
FR900482, a close cousin of mitomycin C that exploits mitosene-based DNA cross-linking.
    Chemistry & biology, 1997, Volume: 4, Issue:2

    Topics: Alkylation; Antibiotics, Antineoplastic; Base Sequence; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Adducts; DNA Footprinting; Isomerism; Mass Spectrometry; Mitomycin; Models, Molecular; Molecular Sequence Data; Oxazines

1997
FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo.
    Chemistry & biology, 2000, Volume: 7, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Base Sequence; Cell Division; Cross-Linking Reagents; DNA; DNA-Binding Proteins; High Mobility Group Proteins; Histocytochemistry; HMGA1a Protein; Humans; Jurkat Cells; Mitomycin; Models, Molecular; Molecular Sequence Data; Molecular Structure; Necrosis; Oncogene Proteins; Oxazines; Phosphoproteins; Precipitin Tests; Protein Structure, Tertiary; Substrate Specificity; Transcription Factors

2000
Synthesis of the mitomycin and FR900482 ring systems via dimethyldioxirane oxidation.
    Organic letters, 2003, Mar-20, Volume: 5, Issue:6

    Topics: Indicators and Reagents; Mitomycin; Nucleic Acid Synthesis Inhibitors; Oxazines; Oxidation-Reduction; Stereoisomerism

2003
Synthetic and biosynthetic studies on FR900482 and mitomycin C: an efficient and stereoselective hydroxymethylation of an advanced benzazocane intermediate.
    Organic letters, 2007, Dec-20, Volume: 9, Issue:26

    Topics: Antineoplastic Agents; Azo Compounds; Methylation; Mitomycin; Oxazines; Stereoisomerism

2007
Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C.
    Organic letters, 2009, Feb-19, Volume: 11, Issue:4

    Topics: Antibiotics, Antineoplastic; Mitomycin; Molecular Structure; Oxazines; Stereoisomerism; Streptomyces

2009