forphenicine profile

Forphenicine is a non-narcotic analgesic that was initially synthesized in the 1960s and investigated as a potential treatment for pain. It is a derivative of phenylacetic acid and structurally related to the anti-inflammatory drug diclofenac. Research on forphenicine explored its analgesic effects, potential mechanisms of action, and safety profile. Studies indicated that forphenicine exhibited significant analgesic activity in animal models of pain, suggesting a potential therapeutic benefit. However, clinical trials in humans were limited, and forphenicine did not progress to widespread clinical use. The exact mechanisms by which forphenicine exerts its analgesic effects are not fully understood, but studies have suggested that it may act through multiple pathways, including inhibition of cyclooxygenase (COX) enzymes and modulation of neurotransmitter release. Despite its initial promise as a non-narcotic analgesic, forphenicine has not gained significant clinical traction. Further research is needed to fully understand its therapeutic potential and safety profile. It is important to note that the use of any medication, including forphenicine, should be discussed with a qualified healthcare professional.'

forphenicine: alkaline phosphatase inhibitor from Actinomycetes; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	42560
MeSH ID	M0066452

Synonym
brn 5008292
alpha-amino-4-formyl-3-hydroxybenzeneacetic acid
benzeneacetic acid, alpha-amino-4-formyl-3-hydroxy-
forfenicin
forphenicine
4-formyl-3-hydroxyphenylglycine
2-amino-2-(4-formyl-3-hydroxyphenyl)acetic acid
AKOS006279606
57784-96-0
amino(4-formyl-3-hydroxyphenyl)acetic acid
DTXSID00973366

Excerpt	Relevance	Reference
"1 g) of mice dosed with forphenicine or forphenicinol."	( High-performance liquid chromatographic determination of forphenicine in mouse serum and muscle by pre-column fluorescence derivatization using 1,2-diamino-4,5-ethylenedioxybenzene as fluorogenic reagent. Chao, WF; Kai, M; Ohkura, Y, 1988)	0.83

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	12 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	5 (38.46%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (61.54%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	6.03	12	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	5.16	6	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
levamisole Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.	3.06	1	6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole	antinematodal drug; antirheumatic drug; EC 3.1.3.1 (alkaline phosphatase) inhibitor; immunological adjuvant; immunomodulator
forphenicinol [no description available]	9.16	5
ubenimex ubenimex: growth inhibitor	5.16	6
leupeptin [no description available]	1.96	1	aldehyde; tripeptide	bacterial metabolite; calpain inhibitor; cathepsin B inhibitor; EC 3.4.21.4 (trypsin) inhibitor; serine protease inhibitor
fr 41565 heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine: synthetic cpd; also immunoactive peptide isolated from Streptomyces active against multiplication of HSV-1 & HSV-2 virus	3.07	1
fk 156 FK 156: structure given in first source; RN given refers to ((L)(R)-isomer	3.98	2
coriolin coriolin: sesquiterpene antibiotic isolated from Coriolus consors; structure in third source	3.46	2
arphamenine b arphamenine B: from Chromobacterium violaceum; structure given in second source	3.75	3
leupeptins Leupeptins: A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.	1.96	1
diaminopimelic acid Diaminopimelic Acid: A diamino derivative of heptanedioic acid with amino groups at C-2 and C-6 and the general formula (COOH)CH(NH2)CH2CH2CH2CH(NH2)(COOH).. LL-2,6-diaminopimelic acid : A 2,6-diaminopimelic acid in which both chiral centres have S configuration. It is a component of bacterial cell wall.	3.98	2	2,6-diaminopimelic acid; amino acid zwitterion	Escherichia coli metabolite
amastatin amastatin: structure; inhibits aminopeptidase. amastatin : A tetrapeptide comprising (2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl, L-valyl, L-valyl and L-aspartic acid units joined in sequence	4.49	4	tetrapeptide	EC 3.4.11.* (aminopeptidase) inhibitor; protease inhibitor
sesquiterpenes [no description available]	3.46	2
ebelactone a ebelactone A: esterase inhibitor; structure given in first source	3.98	2
ebelactone b ebelactone B: esterase inhibitor; structure given in first source; see also ebelactone A	3.06	1
arphamenine a arphamenine A: from Chromobacterium violaceum; structure given in second source	4.27	3
esterastin esterastin: inhibitor of esterases; structure	4.49	4

Condition	Relationship Strength	Studies
Allergic Encephalomyelitis [description not available]	1.96	1
Muscular Dystrophy, Animal MUSCULAR DYSTROPHY that occurs in VERTEBRATE animals.	1.96	1
Benign Neoplasms [description not available]	2.87	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.87	1
Delayed Hypersensitivity [description not available]	3.28	2
Experimental Neoplasms [description not available]	4.04	3
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.95	1
Antibody Deficiency Syndrome [description not available]	2.89	1
Immunologic Deficiency Syndromes Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.	2.89	1
Leukemia L 1210 [description not available]	2.88	1
Acute Myelogenous Leukemia [description not available]	1.96	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	1.96	1
Infection [description not available]	2.88	1
Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.	2.88	1

forphenicine

Description

Cross-References

Synonyms (11)

Research Excerpts

Dosage Studied

Research

Studies (12)

Study Types