cyclohexamethylene carbamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Cyclohexamethylene carbamide, also known as hexamethylenetetramine (HMT), is a white crystalline organic compound with the formula (CH2)6N4. It is synthesized by reacting formaldehyde with ammonia. HMT is a versatile chemical with various applications, including as a pharmaceutical ingredient, a resin precursor, and a fuel additive. It is widely used in the production of plastics, explosives, and pharmaceuticals. HMT is a key intermediate in the production of other chemicals, such as melamine and hexamine. It is also used as a curing agent in epoxy resins and a crosslinking agent in polymers. The importance of HMT lies in its diverse industrial applications and its role as a building block for various chemical syntheses. It is studied for its potential applications in areas such as catalysis, materials science, and medicine. HMT has also been investigated for its antimicrobial and antiviral properties.'

cyclohexamethylene carbamide: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	14283
CHEMBL ID	366975
SCHEMBL ID	26181
MeSH ID	M0067684

Synonyms (43)

Synonym
unii-8a54a97ycr
8a54a97ycr ,
4-09-00-00026 (beilstein handbook reference)
EN300-31269
cyclohexyl carboxyamide
brn 0507595
einecs 214-351-4
nsc 16584
cyclohexamethylene carbamide
1122-56-1
hexahydrobenzoic acid amide
nsc-16584
cyclohexylcarboxamide
cyclohexanamide
cyclohexylcarboxyamide
nsc16584
cyclohexanecarboxamide
cyclohexaneformamide
inchi=1/c7h13no/c8-7(9)6-4-2-1-3-5-6/h6h,1-5h2,(h2,8,9
hexahydrobenzamide
cyclohexanecarboxamide, 97%
CHEMBL366975
cyclohexanecarboxylic acid amide
AKOS001445426
A802524
FT-0624185
PS-4522
SCHEMBL26181
cyclohexane-carboxamide
carbamoyl-cyclohexane
cyclohexane-1-carboxamide
1-cyclohexanecarboxamide
cyclohexane carboxamide
DTXSID1061528
mfcd00009693
W-108650
wm2 ,
bdbm50224864
Q27270087
CS-W013481
BAA12256
SY064829
Z33546516

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Alcohol dehydrogenase E chain	Equus caballus (horse)	Ki	250.0000	0.1412	2.8927	8.7000	AID33720
Alcohol dehydrogenase S chain	Equus caballus (horse)	Ki	250.0000	0.1412	2.8927	8.7000	AID33720
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID251619	inhibition of Candida albicans was measured by zone diameter	2004	Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23	Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study.
AID244826	Minimal inhibitory concentration against Candida albicans	2004	Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23	Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study.
AID33720	In vitro inhibition against horse liver alcohol dehydrogenase	1983	Journal of medicinal chemistry, Jun, Volume: 26, Issue:6	Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (62.50)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (25.00)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.65 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.14 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.65)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	1.97	1	amino-acid anion
tetramethylene sulfoxide [no description available]	1.96	1	tetrahydrothiophenes
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	2.02	1	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.02	1	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
diethyl sulfoxide [no description available]	1.96	1
ethylene oxide Ethylene Oxide: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794). oxirane : A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom.	1.93	1	gas molecular entity; oxacycle; saturated organic heteromonocyclic parent	allergen; mouse metabolite; mutagen
isovaleramide isovaleramide: inhibits liver alcohol dehydrogenases	1.96	1
2-piperidone 2-piperidone: structure given in first source. piperidin-2-one : A delta-lactam that is piperidine which is substituted by an oxo group at position 2.	1.96	1	delta-lactam; piperidones	EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor
methyl phenyl sulfoxide (methylsulfinyl)benzene : A sulfoxide resulting from the formal oxidation of the sulfur atom of thioanisole.	1.96	1	benzenes; sulfoxide
isobutyramide [no description available]	1.96	1	carboximidic acid
3-chloropropionamide 3-chloropropionamide: structure in first source	1.96	1
cyclopropanecarboxamide cyclopropylcarboxamide : Carboxamides RC(=O)NR'R'' where R is a cyclopropyl group.	1.96	1	cyclopropylcarboxamide
thiosemicarbazide thiosemicarbazide: glutamate decarboxylase antagonist; structure given in first source. hydrazinecarbothioamide : A member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group.	1.96	1	hydrazines; thiocarboxamide; thioureas
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	1.96	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore

Condition	Relationship Strength	Studies
Koch's Disease [description not available]	1.93	1
Pulmonary Consumption [description not available]	1.93	1
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	1.93	1
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	1.93	1

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