Page last updated: 2024-11-05

cyclohexamethylene carbamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Cyclohexamethylene carbamide, also known as hexamethylenetetramine (HMT), is a white crystalline organic compound with the formula (CH2)6N4. It is synthesized by reacting formaldehyde with ammonia. HMT is a versatile chemical with various applications, including as a pharmaceutical ingredient, a resin precursor, and a fuel additive. It is widely used in the production of plastics, explosives, and pharmaceuticals. HMT is a key intermediate in the production of other chemicals, such as melamine and hexamine. It is also used as a curing agent in epoxy resins and a crosslinking agent in polymers. The importance of HMT lies in its diverse industrial applications and its role as a building block for various chemical syntheses. It is studied for its potential applications in areas such as catalysis, materials science, and medicine. HMT has also been investigated for its antimicrobial and antiviral properties.'

cyclohexamethylene carbamide: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14283
CHEMBL ID366975
SCHEMBL ID26181
MeSH IDM0067684

Synonyms (43)

Synonym
unii-8a54a97ycr
8a54a97ycr ,
4-09-00-00026 (beilstein handbook reference)
EN300-31269
cyclohexyl carboxyamide
brn 0507595
einecs 214-351-4
nsc 16584
cyclohexamethylene carbamide
1122-56-1
hexahydrobenzoic acid amide
nsc-16584
cyclohexylcarboxamide
cyclohexanamide
cyclohexylcarboxyamide
nsc16584
cyclohexanecarboxamide
cyclohexaneformamide
inchi=1/c7h13no/c8-7(9)6-4-2-1-3-5-6/h6h,1-5h2,(h2,8,9
hexahydrobenzamide
cyclohexanecarboxamide, 97%
CHEMBL366975
cyclohexanecarboxylic acid amide
AKOS001445426
A802524
FT-0624185
PS-4522
SCHEMBL26181
cyclohexane-carboxamide
carbamoyl-cyclohexane
cyclohexane-1-carboxamide
1-cyclohexanecarboxamide
cyclohexane carboxamide
DTXSID1061528
mfcd00009693
W-108650
wm2 ,
bdbm50224864
Q27270087
CS-W013481
BAA12256
SY064829
Z33546516
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Alcohol dehydrogenase E chainEquus caballus (horse)Ki250.00000.14122.89278.7000AID33720
Alcohol dehydrogenase S chainEquus caballus (horse)Ki250.00000.14122.89278.7000AID33720
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID251619inhibition of Candida albicans was measured by zone diameter2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study.
AID244826Minimal inhibitory concentration against Candida albicans2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study.
AID33720In vitro inhibition against horse liver alcohol dehydrogenase1983Journal of medicinal chemistry, Jun, Volume: 26, Issue:6
Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.65 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]