Compounds > capsinolol
Page last updated: 2024-11-11

capsinolol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

capsinolol: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9887704
CHEMBL ID366352
MeSH IDM0273295

Synonyms (5)

Synonym
CHEMBL366352
capsinolol
n-[[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3-methoxyphenyl]methyl]nonanamide
Q16955814
DTXSID401031593
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID171503Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 5 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID180098Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 5 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID79519Positive inotropic effect was evaluated on atrial muscles of the guinea pig1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID180095Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 10 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID171500Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 10 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID180096Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 15 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID171630Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 60 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID180097Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 30 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID79518Positive chronotropic effect was evaluated on atrial muscles of the guinea pig1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID171502Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 30 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID171501Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 15 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
AID180099Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 60 min after inducing the compound on dose of 1.0 mg/kg1994Journal of medicinal chemistry, Apr-01, Volume: 37, Issue:7
Guaiacoxypropanolamine derivatives of capsaicin: a new family of beta-adrenoceptor blockers with intrinsic cardiotonic properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.0110alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
nonivamide
nonivamide: has effect on sensory neurons. nonivamide : A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.		1.9810capsaicinoid;
phenols		lachrymator
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		1.9910catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
propranolol
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.		2.3920naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
vanillic acid
Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.		2.0110methoxybenzoic acid;
monohydroxybenzoic acid		plant metabolite
capsaicin
ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.		3.0950capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
capsazepine
capsazepine: modified capsaicin molecule; a capsaicin receptor antagonist. capsazepine : A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist.		2.0110benzazepine;
catechols;
monochlorobenzenes;
thioureas		capsaicin receptor antagonist
glyceryl nonivamide
N-(4-O-glycerol-3-methoxybenzyl)nonivamide: structure given in first source		2.0110
anandamide
anandamide : An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.		2.0110endocannabinoid;
N-acylethanolamine 20:4		human blood serum metabolite;
neurotransmitter;
vasodilator agent
arvanil
arvanil: structure in first source		2.0110methoxybenzenes;
phenols
ConditionIndicatedRelationship StrengthStudiesTrials
Bradyarrhythmia
[description not available]		01.9910
Tachyarrhythmia
[description not available]		01.9910
Bradycardia
Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.		01.9910
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9910
Tachycardia
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.		01.9910