bimoclomol and Hypertension

This study was designed to investigate the effects of subchronic bimoclomol treatment on endothelial function and expression of 72 kD heat shock protein (HSP-72) in spontaneously hypertensive rats. Endothelial function was tested by monitoring vascular responses to acetylcholine in isolated aortic ring preparations. Polymerase chain reaction was applied to determine HSP-72 mRNA content in the tissue samples. Significant age-dependent declines in relaxation to acetylcholine and vascular HSP-72 mRNA levels were observed in the spontaneously hypertensive animals. Both changes were prevented by subchronic application of bimoclomol suggesting that preservation of endothelial function might be related to sustained levels of HSP-72.

Topics: Acetylcholine; Aging; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Endothelium, Vascular; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Hypertension; Imides; In Vitro Techniques; Male; Methoxamine; Muscle Relaxation; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Inbred SHR; RNA, Messenger