amphidinol 3

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

amphidinol 3: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	46883805
CHEMBL ID	1093589
MeSH ID	M0404519

Synonyms (2)

Synonym
CHEMBL1093589
amphidinol 3

Research Excerpts

Overview

Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate.

Excerpt	Reference	Relevance
"Amphidinol 3 (AM3) is a potent antifungal produced by the dinoflagellate "	( Total Synthesis of Amphidinol 3: A General Strategy for Synthesizing Amphidinol Analogues and Structure-Activity Relationship Study. Ebine, M; Matsumori, N; Oishi, T; Wakamiya, Y, 2020)	2.33
"Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. "	( Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3. Iwamoto, M; Kinoshita, M; Matsumori, N; Oiki, S; Shimada, E; Sumino, A, 2017)	2.13

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID474963	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome assessed as overall equilibrium association constant at 10 uM by surface plasmon resonance assay in presence of 5% cholesterol	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474960	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome assessed as association constant for compound- PPC liposome reorientation complex at 10 uM by surface plasmon resonance assay in presence of 5% cholesterol	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474958	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome at 10 uM by surface plasmon resonance assay in presence of 5% ergosterol	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474965	Permeability across egg phosphatidylcholine membrane	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474959	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome assessed as association constant for compound- PPC liposome reorientation complex at 10 uM by surface plasmon resonance assay	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474956	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome at 10 uM by surface plasmon resonance assay	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474962	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome assessed as overall equilibrium association constant at 10 uM by surface plasmon resonance assay	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474961	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome assessed as association constant for compound- PPC liposome reorientation complex at 10 uM by surface plasmon resonance assay in presence of 5% ergosterol	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474957	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome at 10 uM by surface plasmon resonance assay in presence of 5% cholesterol	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
AID474964	Binding affinity to synthetic palmitoyl-oleoyl-phosphatidylcholine liposome assessed as overall equilibrium association constant at 10 uM by surface plasmon resonance assay in presence of 5% ergosterol	2010	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7	Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (50.00)	29.6817
2010's	14 (46.67)	24.3611
2020's	1 (3.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (96.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
malic acid malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.. 2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.	2.02	1	2-hydroxydicarboxylic acid; C4-dicarboxylic acid	food acidity regulator; fundamental metabolite
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2.15	1
n-methyl-4-nitroaniline N-methyl-4-nitroaniline: structure in first source	2.07	1
alkenes [no description available]	5.89	30
fluorexon fluorexon: structure	2.15	1	xanthene dye	fluorochrome
tartaric acid tartaric acid: RN given refers to cpd with unspecified isomeric designation. D-tartaric acid : The D-enantiomer of tartaric acid.	2.05	1	tartaric acid	Escherichia coli metabolite
ergosterol [no description available]	7.77	3	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
glycosides [no description available]	2.02	1
lithium Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	2.11	1	alkali metal atom
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	7.44	2	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
dimyristoylphosphatidylcholine 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).	2.04	1	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite
1-palmitoyl-2-oleoylphosphatidylcholine 1-palmitoyl-2-oleoylphosphatidylcholine: RN given refers to (Z)-isomer	2.15	1
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.48	2	1,2-diacyl-sn-glycero-3-phosphocholine
glycolipids [no description available]	2.15	1
pemetrexed theonellamide A: from Theonella marine sponges; structure in first source	2.15	1
filipin Filipin: A complex of polyene antibiotics obtained from Streptomyces filipinensis. Filipin III alters membrane function by interfering with membrane sterols, inhibits mitochondrial respiration, and is proposed as an antifungal agent. Filipins I, II, and IV are less important.	2.02	1

Condition	Indicated	Relationship Strength	Studies	Trials
Extravascular Hemolysis [description not available]	0	2.02	1	0
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	0	2.02	1	0

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