Compounds > 2,3-Dimethylpyrazine
Page last updated: 2024-12-06

2,3-Dimethylpyrazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,3-Dimethylpyrazine is a heterocyclic compound with a characteristic roasted and nutty aroma. It is found naturally in roasted coffee beans, roasted peanuts, and other roasted foods. 2,3-Dimethylpyrazine is synthesized through a variety of methods, including the reaction of 2-methylpyrazine with methyl iodide or the reaction of 2,3-dichloropyrazine with methyl magnesium bromide. It is used as a flavoring agent in food and beverages and is also used as a fragrance component. The compound is studied for its potential health benefits, including its antioxidant and anti-inflammatory properties. 2,3-Dimethylpyrazine has been shown to inhibit the growth of certain cancer cells and to protect against oxidative stress. It is also studied for its potential to enhance cognitive function.'

2,3-dimethylpyrazine: an odorant that stimulates Grueneberg ganglion neurons; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID22201
CHEMBL ID96425
CHEBI ID193606
SCHEMBL ID151026
SCHEMBL ID19919479

Synonyms (41)

Synonym
2,3-dimethyl-pyrazine
CHEMBL96425
2,3-dimethylpyrazine
pyrazine, 2,3-dimethyl-
fema no. 3271
ccris 2928
2,3-dimethyl-1,4-diazine
2,3-dimethylpyrazine (natural)
einecs 227-630-0
inchi=1/c6h8n2/c1-5-6(2)8-4-3-7-5/h3-4h,1-2h
2,3-dimethylpyrazine, >=95%, fcc, fg
2,3-dimethylpyrazine, 99%
5910-89-4
D1525
CHEBI:193606
A832162
AKOS007930710
unii-whf7883d0v
whf7883d0v ,
FT-0609727
25704-73-8
pyrazine, dimethyl-
S12348
2,3-dimethylpyrazine [fhfi]
2,3-dimethylpyrazine [fcc]
SCHEMBL151026
dimethylpyrazine
2,3-dimethyl pyrazine
DTXSID4064058
AM87085
mfcd00006144
2,3-dimethylpyrazine, analytical reference material
fema 3271
2,3-dimethlpyrazine
SCHEMBL19919479
AS-14037
Q27292638
CS-W016630
EN300-44307
HY-W015914
Z448248230
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyrazines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID233350Olfactory detection threshold value and quantitative measure of odour impression; No threshold value.2001Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
Prediction of the aroma quality and the threshold values of some pyrazines using artificial neural networks.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.04 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index46.50 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2,3-butylene glycol
2,3-butylene glycol: RN given refers to cpd without isomeric designation. butane-2,3-diol : A butanediol in which hydroxylation is at C-2 and C-3.		2.1510butanediol;
glycol;
secondary alcohol
glycine
[no description available]		2.5820alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		3.4260diazine;
pyrazines		Daphnia magna metabolite
tetramethylpyrazine
tetramethylpyrazine: found in Ligusticum chuanxiong. tetramethylpyrazine : A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).		210alkaloid;
pyrazines		antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
neuroprotective agent;
platelet aggregation inhibitor;
vasodilator agent
furaneol
furaneol: RN given refers to compound with no isomeric designation. 4-hydroxy-2,5-dimethylfuran-3-one : A member of the class of furans that is 2,5-dimethylfuran carrying additional oxo and hydroxy groups at positions 3 and 4 respectively. It has been found particularly in strawberries and other such fruits.		2.5820cyclic ketone;
enol;
furans		flavouring agent;
fragrance;
plant metabolite
2-ethyl-3,6-dimethylpyrazine
2-ethyl-3,6-dimethylpyrazine: a component of leaf-cutting ant pheromones		210
2-ethyl-3,5-dimethylpyrazine
2-ethyl-3,5-dimethylpyrazine: structure in first source		210pyrazines
2,3,5-trimethylpyrazine
2,3,5-trimethylpyrazine: key aroma compound in beef extract. trimethylpyrazine : A member of the class of pyrazines that is pyrazine in which three hydrogens at positions 2, 3 and 5 have been replaced by methyl groups.		210pyrazinesanimal metabolite;
bacterial metabolite;
flavouring agent;
pheromone;
plant metabolite
2,5-dimethylpyrazine
[no description available]		210pyrazines
2-isobutyl-3-methoxypyrazine
[no description available]		210
2-isopropyl-3-methoxypyrazine
2-isopropyl-3-methoxypyrazine: structure given in first source		210
2,5-dimethyl-3-methoxypyrazine
[no description available]		210
ConditionIndicatedRelationship StrengthStudiesTrials
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.		02.2510
Disease Resistance
The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.		02.1510