Compounds > 2-ethyl-3,6-dimethylpyrazine
Page last updated: 2024-12-06

2-ethyl-3,6-dimethylpyrazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-ethyl-3,6-dimethylpyrazine, also known as ethyldimethylpyrazine, is a heterocyclic compound belonging to the pyrazine family. It is a colorless liquid with a characteristic roasted peanut-like aroma and is often found in roasted coffee, chocolate, and other food products. This compound is particularly important for its role in flavor generation. It is produced during the Maillard reaction, a complex chemical process that occurs during the heating of food. The reaction between reducing sugars and amino acids leads to the formation of a variety of aroma compounds, including 2-ethyl-3,6-dimethylpyrazine. The compound is also found in roasted malt, and it contributes to the characteristic aroma and taste of beer. It is considered to be a flavor enhancer and is sometimes added to foods and beverages as a flavoring agent. Researchers study 2-ethyl-3,6-dimethylpyrazine to understand its formation mechanism, its role in flavor perception, and its potential applications in the food industry.'

2-ethyl-3,6-dimethylpyrazine: a component of leaf-cutting ant pheromones [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25916
CHEMBL ID95123
SCHEMBL ID160005
MeSH IDM0490174

Synonyms (27)

Synonym
CHEMBL95123
13360-65-1
pyrazine, 2-ethyl-3,?-dimethyl-
2-ethyl-3,6-dimethylpyrazine
pyrazine, 3-ethyl-2,5-dimethyl-
3-ethyl-2,5-dimethylpyrazine
AKOS006271522
einecs 236-417-1
g2fb13vlog ,
unii-g2fb13vlog
2e3,6dmp
2,5-dimethyl-3-ethylpyrazine
3,6-cocoa pyrazine
fema no. 3149, 3,6-dimethyl-
3,6-dimethyl-2-ethylpyrazine
2-ethyl-3,6-dimethyl pyrazine
SCHEMBL160005
DTXSID1065423
pyrazine, 2-ethyl-3,6-dimethyl
W-108294
2-ethyl-3,5/6-dimethyl-pyrazine
F20894
BS-14917
Q27278651
A902157
CS-0152557
3-ethyl-2,5-dimethylpyrazine; 2,5-dimethyl-3-ethylpyrazine; 3,6-dimethyl-2-ethylpyrazine;

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The data and information available, including a prolonged history of safe use, indicate that at the current level of intake, the food flavoring use of 2-ethyl-3,(5 or 6)-dimethylpyrazine is safe."( Safety assessment of 2-ethyl-3,(5 or 6) dimethylpyrazine as a food ingredient.
Burdock, GA; Carabin, IG, 2008)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID233351Evaluated for its olfactory detection threshold value and indicates quantitative measure of odour impression; No threshold value.2001Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
Prediction of the aroma quality and the threshold values of some pyrazines using artificial neural networks.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.98 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index23.70 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetone
methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).		7.2510ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
aminoacetone
aminoacetone: RN given refers to parent cpd. aminoacetone : A propanone consisting of acetone having an amino group at the 1-position.		7.2510methyl ketone;
propanones		Escherichia coli metabolite;
mouse metabolite
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		2.0210butan-4-olidemetabolite;
neurotoxin
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0210pyrrole;
secondary amine
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		3.4370diazine;
pyrazines		Daphnia magna metabolite
2,3-pentanedione
pentane-2,3-dione : An alpha-diketone that is pentane substituted at the 2- and 3-positions by oxo groups.		7.2510alpha-diketone;
methyl ketone		flavouring agent
tetramethylpyrazine
tetramethylpyrazine: found in Ligusticum chuanxiong. tetramethylpyrazine : A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).		210alkaloid;
pyrazines		antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
neuroprotective agent;
platelet aggregation inhibitor;
vasodilator agent
2,3-Dimethylpyrazine
2,3-dimethylpyrazine: an odorant that stimulates Grueneberg ganglion neurons; structure in first source		210pyrazines
2-ethyl-3,5-dimethylpyrazine
2-ethyl-3,5-dimethylpyrazine: structure in first source		8.1550pyrazines
2,3,5-trimethylpyrazine
2,3,5-trimethylpyrazine: key aroma compound in beef extract. trimethylpyrazine : A member of the class of pyrazines that is pyrazine in which three hydrogens at positions 2, 3 and 5 have been replaced by methyl groups.		210pyrazinesanimal metabolite;
bacterial metabolite;
flavouring agent;
pheromone;
plant metabolite
2,5-dimethylpyrazine
[no description available]		210pyrazines
2-isobutyl-3-methoxypyrazine
[no description available]		210
2-isopropyl-3-methoxypyrazine
2-isopropyl-3-methoxypyrazine: structure given in first source		210
2,5-dimethyl-3-methoxypyrazine
[no description available]		210
ConditionIndicatedRelationship StrengthStudiesTrials
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0410